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| where is DA input lost in PD |
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| after 60-80 of nigral DA cell bodies are out |
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| tremor, bradykinesia, rigidity, postural defect |
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| mech of inheritance of Huntington's |
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| where is most of the cell degredation in HD? |
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| chorea, progressive dementia |
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| what is the meso/neostriatal system |
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| DA projection from nigra to neostriatum |
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| what is the role of the neostrial system |
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| initiation and maint of movement |
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| what is the mesolimbocortical system? |
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| DA from midbrain to limbic/cortical structures |
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| what is the role of the mesolimbocortical system? |
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| regulation of cognitive/emotional processes |
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| what is the hypothalamo-hypophyseal system? |
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| hypothal DA neurons releasing DA into portal system |
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| what is the chemoreceptor trigger zone? |
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| DA in area postrema induces N+V |
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| what two parts of the dopamine system are affected in PD? |
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| neostriatal, mesolimbocortical (sometimes) |
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| what is the source of most symptomes of PD? |
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| disinhibition of the indirect movement inhibitory pathway: striatal-pallidal-subthal-pallidal-thal-cortical loop |
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| course of PD treatment (general classes) |
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| MAOi, DA releaser, DA ag, DA precursor, COMTi |
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| dyskinesia, confusion/delirium, hallucinations, paranoia, anx, n+v |
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| other clinical uses of l-dopa |
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| why should l-dopa not be taken w/ food? |
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| competes w/ aa transporters, inhibited by low gastric pH |
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| other clinical uses of bromocriptine? |
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| problem with oral admin of bromocriptine? |
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| bromocriptine and albumin? |
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| anorexia, n+v, hypoTN, arryth, dyskinesis, psych |
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| restlessness, insom, irritable, conf; enhanced effects of anti-cholinergics |
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| active metabolite of selegiline |
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| striatal NT in indirect pathway |
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| striatal NT in direct pathway |
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| striatal NT in interneurons |
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| DR in interneuron pathway |
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