Term
| why are benzos used in treating anxiety? |
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Definition
| get people "over the hump" until SSRI kicks in |
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Term
| what are the most common benzos used with SSRIs to treat anxiety? |
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Definition
|
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Term
|
Definition
| 5-HT1A receptor agonist, D2R agonist |
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Term
| gen considerations for choosing a benzo as an adjunct for anxiety |
|
Definition
| rapidity of onset, duration, hl, metabolism |
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Term
| what benzos are used as anticonvulsants? |
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Definition
|
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Term
| what benzos are used as anesthesia adjuncts? |
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Definition
|
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Term
| gen char of benzos used as anesthesia adjuncts? |
|
Definition
| highly lipophilic, rapid onset |
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Term
| benzo used as a muscle relaxant? |
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Definition
|
|
Term
| benzos approved for use a sleep drugs |
|
Definition
| estaz, temaz, quaz, fluraz, triaz |
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Term
| why should triaz be avoided if possible? |
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Definition
|
|
Term
| benzos less likely to have decreased met with age? |
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Definition
|
|
Term
| more severe sed-hyp withdrawl as it relates to dose |
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Definition
|
|
Term
| more severe sed-hyp withdrawl as it relates to duration of use |
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Definition
|
|
Term
| more severe sed-hyp withdrawl as it relates to potency |
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Definition
|
|
Term
| more severe sed-hyp withdrawl as it relates to half-life |
|
Definition
|
|
Term
| more severe sed-hyp withdrawl as it relates to time of onset |
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Definition
|
|
Term
| action of zolpidem (Ambien) |
|
Definition
|
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Term
|
Definition
|
|
Term
| time to peak plasma conc for zolpidem? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| n+v+d, HA, dizzy, hi dose: amnesia, rebound insomnia |
|
|
Term
| time to peak action for zaleplon |
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Definition
|
|
Term
|
Definition
|
|
Term
| met of zaleplon inhibited by? |
|
Definition
| cimetidine (Tagamet) H-2 blocker |
|
|
Term
| which has worse hangover, zolpidem, zaleplon? |
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Definition
|
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Term
|
Definition
|
|
Term
| does eszopiclone alter stages of sleep? |
|
Definition
|
|
Term
| peak plamsa conc of eszopiclone? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| eszopiclone eliminated more slowly in the elderly? |
|
Definition
|
|
Term
| potentiating interacting drugs with eszopiclone (3) |
|
Definition
| itraconazole, clarithro, ritonovir (CYP3A4I) |
|
|
Term
| antagonizing interacting drug with eszopiclone? |
|
Definition
| rifampicin (CYP3A4 activator) |
|
|
Term
|
Definition
| a2 antagonist, 5-HT 2A 2C 3 blocker, increases 5-HT at 5-HT1AR |
|
|
Term
|
Definition
|
|
Term
| action of amitriptyline at H1/H2 R |
|
Definition
|
|
Term
| action of amitriptyline at Musc, A1 R |
|
Definition
|
|
Term
|
Definition
| orthostatic hypotension, cardiotox, confusion |
|
|
Term
| H-1R antagonists used for treatment of insomnia |
|
Definition
| cyclobenzaprine, hydroxyzine, diphenhydramine |
|
|
Term
|
Definition
| 5-HT2AR antag, 5-HT reuptake inhibitor |
|
|
Term
| does Nefazadone interfere w/ sex? |
|
Definition
|
|
Term
| brain regions involved in anxiety? |
|
Definition
| amyg, mesiotemporal structures, thalamus, orbital/medial prefrontal cortex, insula, hypothalamus, brainstem nuclei |
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|
Term
|
Definition
|
|
Term
| neuropeptides involved in anxiety |
|
Definition
|
|
Term
| rationale for use of benzos in anxiety (4) |
|
Definition
| high TI, low liver induction, slow elimination, flumazenil |
|
|
Term
| important beneficial characteristics of lorazepam for treatment of anxiety |
|
Definition
|
|
Term
|
Definition
| preexisting CNS depress, hyptotension, narrow angle glaucoma, ren/hep impaired, MG, PD |
|
|
Term
| does buspirone produce an active metabolite? |
|
Definition
|
|
Term
| contraindications of buspirone |
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
| preexist seizure, MI, heart diseas, hep/ren |
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
|
Definition
| panic, depression, social anx, OCD |
|
|
Term
|
Definition
| seizure hx, mania, ren/card |
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|
Term
|
Definition
|
|
Term
|
Definition
| hep/card, seizure hx, suicidial hx |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| venlafaxine, paroxetine, busp, loraz, clonaz |
|
|
Term
|
Definition
| sertraline, loraz, alpraz, clonaz |
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Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
| adverse effects of B-blockers used to treat sit anx |
|
Definition
| lethargy, vivid dreams, hallucinations |
|
|
Term
|
Definition
| hypertherm, muscle rigidity, clonus, changes in cognition, changes in vitals |
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