Term
| ____ blocks synthesis of vasodialtor prostaglandins (PGE2, PGI2) which will block afferent constriction/dilatation and reduce/increase blood flow and GFR |
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Definition
| Indomethacin; dilatation; reduce |
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Term
| What can cause filtration to fall? (3) |
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Definition
| low blood pressure; low blood volume; change in vascular resistance |
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Term
| Some leakiness at filtration barrier leads to ... |
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Definition
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Term
| high plasma digoxin levels leads to ... |
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Definition
| affected heart conduction, bradycardia, low cardiac output |
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Term
| Does creatinine clearance = GFR? |
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Definition
| No, but it's a good approximation |
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Term
| Pre-renal failure: (prerenal azotemia or elevated BUN) is when normal __:__ (BUN:Cr) may be __:__ or higher b/c, in addition to the GFR effect on BUN, increased urea reabsorption (appropriate response to dehydration) elevates BUN even further. |
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Definition
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Term
| Pre-renal failure: U osm > ___, U cr/P cr > __, U na < __, Na reabsorb % is < __. |
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Definition
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Term
| Acute Tubular Necrosis (ATN): Trap urea well/ not well, conc/fail to conc urine, Fractional Excretion of Na reaches/does not reach low enough levels. |
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Definition
| not well; fail to conc; does not reach low enough levels (>1%) |
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Term
| Can prerenal failure cause ATN? |
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Definition
| yes, renal ischemia --> tubular damage |
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Term
| Identify 4 messengers working to replenish Mr. Goods's volume/pressure status... |
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Definition
| renin, aldosterone, ADH, catecholamines |
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Term
| Amount of K reabsorbed before the macula densa = __ %. |
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Definition
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Term
| Normal urine conc = ___ mOsm/L is needed to properly conserve ___. |
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Definition
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Term
| inability to concentrate urine is... |
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Definition
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Term
| Which part of conc mechanism has failed for Mr. Good? ____ ; Which hormone regulates urine conc? ___ |
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Definition
| Na pumping in thick ascending loop of Henle is compromised; ADH |
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Term
| low bicarb indicates low/high pH... |
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Definition
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Term
| To measure acid excretion... |
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Definition
| titratable acid + ammonia - bicarb |
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Term
| what will drive higher resp rate? |
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Definition
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Term
| ___% of cardiac ouput flows to kidneys |
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Definition
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Term
| ___% of renal blood lfow perfuses to the cortex. |
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Definition
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Term
| ___% of filtered inulin that is excreted in urine. |
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Definition
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Term
| ___% of PAH cleared from renal plasma in single passage through kidneys. |
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Definition
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