Term
| What are common CNS adverse fx of NSAIDs? |
|
Definition
| Headache, tinnitus, dizziness |
|
|
Term
| Prostaglandins responsible for pain, inflammation & fever are produced by which COX enzyme? |
|
Definition
|
|
Term
| Does aspirin block COX-1 and 2 reversibly or irreversibly? |
|
Definition
|
|
Term
|
Definition
| OA, RA, migraines, ankylosing spondylitis |
|
|
Term
| Which NSAID is indicated for pericarditis? |
|
Definition
|
|
Term
| Which NSAIDs are indicated in acute gouty arthritis? |
|
Definition
|
|
Term
| Which NSAID is most lipophilic (more able to cross blood-brain barrier into CNS)? |
|
Definition
|
|
Term
| Which NSAID is associated w/ pancreatitis and renal papillary necrosis? |
|
Definition
|
|
Term
| Which NSAID is most associated w/ LFT abnormalities? |
|
Definition
|
|
Term
| Which NSAID is associated w/ pseudoporphyria and photosensitivity? |
|
Definition
|
|
Term
| Which has slight preference for COX-1 inhibition: celecoxib or meloxicam? |
|
Definition
|
|
Term
| What is methotrexate's MOA? |
|
Definition
| AICAR enzyme -> increased AMP -> adenosine inhibits inflammation |
|
|
Term
| Is methotrexate more helpful in an acute RA flare or for chronic RA management? |
|
Definition
| Chronic mgmt; in acute flare, add NSAIDs or glucocorticoids |
|
|
Term
| What are the most common toxicities associated w/ methotrexate? |
|
Definition
| Hematologic (anemia, leukopenia), GI, hepatic (check LFTs), pulmonary (hypersensitivity rxn) |
|
|
Term
| Best way to avoid methotrexate toxicities? |
|
Definition
|
|
Term
| What is the major metabolite of azathioprine? |
|
Definition
|
|
Term
| Which nonbiologic DMARD is first line treatment for RA? |
|
Definition
|
|
Term
| Which nonbiologic DMARD is mostly prescribed in solid organ transplant? |
|
Definition
|
|
Term
| Unique toxicities of cyclosporine? |
|
Definition
| Cardiotoxicity, infertility w/ chronic use |
|
|
Term
| Which DMARD is associated w/ diarrhea, mild alopecia, teratogenicity and weight gain toxicities? |
|
Definition
|
|
Term
| Which DMARD inhibits JAK enzymes? |
|
Definition
|
|
Term
| Examples of nonbiologic DMARDs? |
|
Definition
| Methotrexate, azathioprine, cyclosporine, leflunomide, sulfasalazine, tofacitinib |
|
|
Term
| With which DMARD do we need to monitor lipid panels? |
|
Definition
|
|
Term
|
Definition
| Binds to CD80/86 receptor on Antigen Presenting Cell -> prevents T-cell activation and thus inflammation |
|
|
Term
|
Definition
| Targets CD20 B lymphocytes -> apoptosis -> decreased inflammation |
|
|
Term
| What is a common adverse effect of DMARDs? |
|
Definition
| Increased risk of infection |
|
|
Term
|
Definition
|
|
Term
| Most common biologic DMARD class used to treat RA? + examples |
|
Definition
| TNF-alpha blockers (e.g. adalimumab, etanercept, infliximab) |
|
|
Term
| Which DMARDs are indicated in ulcerative colitis? |
|
Definition
| Adalimumab/"Humira", infliximab |
|
|
Term
| Which DMARD is a chimeric IgG monoclonal antibody? |
|
Definition
|
|
Term
| Which drug class of DMARD is associated w/ drug-induced lupus and antidrug antibodies? |
|
Definition
| TNF-alpha blockers (adalimumab, etanercept, infliximab) |
|
|
Term
| What type of crystals are deposited in the joints in gout? |
|
Definition
|
|
Term
| What is colchicine's MOA? |
|
Definition
| Binds to tubulin in neutrophils |
|
|
Term
| Which gout med was first extracted from Autumn Crocus flower? |
|
Definition
|
|
Term
| Which med dose was historically titrated up until the pt had diarrhea (GI toxicity common)? |
|
Definition
|
|
Term
| Which Gout med is also indicated in Familial Mediterranean Fever? |
|
Definition
|
|
Term
|
Definition
| Prevents reabsorption of uric acid in PCT of kidney |
|
|
Term
| Which gout med can prolong penicillin serum levels? |
|
Definition
|
|
Term
|
Definition
| Converted to active metabolite: alloxanthine -> blocks xanthine oxidase from forming uric acid |
|
|
Term
| Which gout med is also indicated in cancer-induced hyperuricemia? |
|
Definition
|
|
Term
| Should you d/c allopurinol therapy in a pt that develops a rash from the medication? |
|
Definition
|
|
Term
| Which gout med inhibits urate crystal phagocytosis? |
|
Definition
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