Term
| Two most concerning SE of Alpha Blockers |
|
Definition
| retrograde ejactulation and orthostatic hypotension |
|
|
Term
| Which 3 alpha blockers have dual indications for BPH and HTN |
|
Definition
| (Does Prostate Too) Doxazosin, Prazosin, Terazosin |
|
|
Term
| Which 3 alpha blockers are for BPH Only |
|
Definition
| Tamsulosin, Sildosin, Alfuzosin |
|
|
Term
| What is MOA of Alpha Blockers in use for BPH |
|
Definition
| The relax the smooth muscle at the bladder neck and prostate increasing flow (does nothing for force) |
|
|
Term
| Which BPH medication class does not have CYP450 DDIs? |
|
Definition
|
|
Term
| Which BPH medication class is Cat X |
|
Definition
| 5 Alpha reductase (probably Saw Palmetto should be too) |
|
|
Term
| What is the MOA of 5 alpha reducace inhibitors |
|
Definition
| Decrease the size of the prostate by inhibting 5 alpha reductase |
|
|
Term
| What are the 2 indications for Finasteride |
|
Definition
| Male Pattern Baldness (alopecia) and BPH |
|
|
Term
| What is the MOA of Saw Palmetto |
|
Definition
| Inhibits 5 alpha reductase |
|
|
Term
|
Definition
| Give low dose dopamin to increase renal perfusion |
|
|
Term
| Chronic Renal Failure can be exaserbated by |
|
Definition
| HF, Drugs, Volume Depletion, Infection or Hypercalcemia |
|
|
Term
| In low doses what two classes can increase renal blood flow |
|
Definition
|
|
Term
| Why are aluminum salts not used to treat hyperphosphatemia |
|
Definition
| ADRS of Osteomalacia, severe constipation |
|
|
Term
| Why isn't sevelamar used to treat hyperphosphatemia |
|
Definition
| While it has the least ADRs it requires 12 pills daily so poor compliance |
|
|
Term
| Cause of urge incontinance |
|
Definition
| Failure of the detrusser muscles |
|
|
Term
| Cause and Tx for Stress incontinance |
|
Definition
| Urethral Sphincter failure, TX: Keelgles |
|
|
Term
| Cause and Tx for overslow incontinance |
|
Definition
| Causes are BPH and drug induced destrussor issues, TX is Alpha 1 Agonists |
|
|
Term
| 3 main Anticholenergics used for incontinance (pot) |
|
Definition
| Propathenline, Oxybutinin, Tolterodine |
|
|
Term
| Which anticholenergic is the prototype for incontinance drugs currently used |
|
Definition
|
|
Term
| Who are anticholenergics precautioned in? |
|
Definition
|
|
Term
| Which Anticholenergic is a Cat B used for incontinance. What is its MOA |
|
Definition
| Oxybutynin. MOA is blocks M3>M1 decreasing urgency and sensation of needing to void |
|
|
Term
| What other ways can Oxybutynin be given. Why choose those? |
|
Definition
| Oxtrol is the patch for given 2 x a week, Gelnique is a gel form given once a week. They have significantly less ADRs and no first pass |
|
|
Term
| Which Anticholenergic has less dry mouth ADRS (what is the ER version called?) |
|
Definition
| Tolterodine (ER version is Fesoterodine) |
|
|
Term
| Which Anticholenergics do not cross the blood brain barrier |
|
Definition
| Darifenacin, Solifenacin (therefor less CNS and severe ADRs) |
|
|
Term
| What is Mirabegron? MOA, ADRs and Reason it isnt used |
|
Definition
| It’s a beta 3 agonist. Rarely used because its expensive. It relaxes bladder muscle increasing storage capacity and its ADRS are HTN, Tachy, Constipation and Diarrhea |
|
|
Term
| What is the TX for Nocturnal Enuresis? How is it given? What other uses does that drug have |
|
Definition
| Desmopressin, given nasally in kids and orally in adults. PO may decrease hyponatremia. Usually tried for up to 6mo for enuresis |
|
|
Term
| Which Trycyclics are used for enuresis (how is it dosed adults vs kids) |
|
Definition
| Imipramine, amitriptyline, doxepin. They are given low dose in kids, high in adults |
|
|
Term
| What is the most commonly used calcium chanel blocker in incontinance |
|
Definition
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