Term
pharmaceutic phase
Tablet and capsules
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Definition
| the dissolution of the drug, and what types of durgs go through this phase? |
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Term
Pharmokenetic Phase
tablets and capsuls, liquid and parenteral drugs |
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Definition
| what the body does to the drug, a drugs activity from the time it enters the body untill it leaves. and what type of drugs go through this phase? |
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Term
Absorbtion
Distribution
Metabolism
excreation
half-life
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Definition
| in the pharmocokinetic phase what are the activities of a drug |
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Term
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Definition
| the transference of drug molecules from point of entry in the body into the blood system |
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Term
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Definition
| protein or enzyme move drug across cell membrane |
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Term
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Definition
| diffusion: from high to low |
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Term
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Definition
| engulfing drug particle to move across cell |
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Term
| active absorbtion,Passive absorbtion, and pinocytosis |
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Definition
| what are the way of absorbtion for a solid drug |
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Term
route of administration
Drug solubility
PH
local conditions at site of administration
Drug dosage
serum dug levels |
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Definition
| what are the factors that influence rate of absorbtion |
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Term
IV imediate
IM
SC
PO
then other absorbtive sites, skin, vagina,rectum,eyes |
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Definition
| What are the routes of administration in order most rapid first? |
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Term
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Definition
this type of drug must have affinity for water- Passes through cell membranes thru water channels
Ex. Vitamins, (pass readily) |
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Term
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Definition
This type of drug is non-ionized is absorbed readily but remains in fatty tissue, Not easily distributed
Ex: Valium |
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Term
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Definition
| A_________medication will be more readily absorbed in the stomach Ex: ibprophen |
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Term
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Definition
| a_______________medication will not be absorbed untill it reaches the small intestine |
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Term
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Definition
| a decrease in the size of an organ or tissue |
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Term
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Definition
| a larger than normal dose given when maximal and quick effect is desired |
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Term
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Definition
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Term
| therapeutic (effect) range |
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Definition
| the desiredeffect in blood without toxicity, the desired concentration in blood serum |
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Term
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Definition
| highest plasma concentration of drug after complete absorbtion. This is measured when complete absorbtion has been achieved. |
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Term
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Definition
| when drug is at the lowest level this is drawn 30min before next dose |
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Term
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Definition
| amt of time it takes for half a dose of a drug to be elimenated from the body |
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Term
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Definition
| transportation from site of absorbtion to site of action is called? |
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Term
depends on physical and chemicalproperty of the drug (water or lipid soluable)
and wheather drug has protien bonding copasity |
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Definition
| what are the factors affecting distribution? |
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Term
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Definition
| Difficult to pass, permits lipid bound meds, and prevents water soluable meds |
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Term
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Definition
| easieier passage of meds permits lipid souluable drugs to enter fetal circulation, prevents other meds from crossing? |
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Term
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Definition
| most drugs are bound to__________ |
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Term
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Definition
| available to cross cell membrane |
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Term
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Definition
| not available for pharmacological action |
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Term
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Definition
| the process of inactivating and breaking down a med |
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Term
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Definition
| primary site: the first-pass effect |
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Term
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Definition
| enzymes in liver,lungs, kidneys,GI,skin break down med into? |
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Term
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Definition
| what are the factors effecting metabolizm |
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Term
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Definition
| enzyme system mature slowly |
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Term
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Definition
| this type of person decrease overall metabolic capacity of liver ( toxicity at normal doses) |
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Term
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Definition
| the process where the metabolites and drugs are elimenated |
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Term
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Definition
| the main organ for drug elimenation |
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Term
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Definition
| the time requried for the body to eliminate 50% of the drug |
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Term
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Definition
| it takes _______half lives to elimiate 98% of adrug from a body |
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Term
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Definition
what the drug does to the body, the drug action and effect within the body.
There is alteration of cell physiology |
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Term
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Definition
| causes an increase of decrease in certain physiological function(hr,BP, urinary output) |
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Term
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Definition
| the unintended effect of a drug |
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Term
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Definition
| the decrease physiologic response of the body to a drug, requireing an increase in dosage to achievew the desired effect. |
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Term
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Definition
| when rate of administration exceeds rate of metabolism |
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Term
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Definition
this is harmful reactions on tissues or organs
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Term
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Definition
| the unusual, abnormal, or pecular reaction to a drug cause not clear |
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Term
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Definition
| devepmental defects of a drug in the embryo or fetus |
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Term
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Definition
| effects occure when 2 drugs with similar pharmocologicalactions are taken together |
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Term
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Definition
occures when 2 drugs with different pharmacological actions produced greater effects when taken together then either dose when taken alone
ex: tylenol w codien |
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Term
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Definition
one drug interfers with the action of others, neutralizes or decreases effect of other
ex: protamine sufate on heparine
narcan on a narcotic |
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Term
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Definition
| inappropriate intake of a substance |
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Term
generic
drug nomenclature |
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Definition
| name given to a drug, less expensive |
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Term
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Definition
| brand or proprietary name, 1st letter always capitolized |
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Term
controlled release
sustained release
slow actiog
long acting
time released |
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Definition
name these abbreviation for types of drugs
CR
SR
SA
LA
TR |
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Term
down &back
straight & back
up & back |
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Definition
ways to give ear drops
infant-3?
school age?
adult? |
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Term
| anagesic, antipyretic,and anti-anflamatory |
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Definition
| pharmacological effects of salicylates (ASA)? |
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Term
| by dialating peripheral blood vessels |
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Definition
| how do salicylates decrease body temp. |
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Term
| it prolonges the bleeding time by inhibiting the aggregation (clumping)of platlets |
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Definition
| what effects does ASA have on bleeding |
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Term
relieving mild to moderate
relieves elevated body temp
tx inflamatory conditions
reducing clots and strokes
helps haintain pregancy |
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Definition
| list common uses of salicylates |
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Term
| gi bleeding,gi upset,anorexia, nausea, allergic reaction,heartburn,vomiting |
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Definition
| adverse reactions with ASA |
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Term
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Definition
| over dose of Salycilic meds, characterized by dizzyness,impaired hearing, Tinnitus nasua, vomiting, tacycardia, sweating, rapid deep breathing, mental confusion, possile coma is called |
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Term
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Definition
non-opioid analgesic
inhibits platelet aggression, is an anaglgesic of choicewhen bleeding tendencys is an issue
antipyretic |
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Term
| liver, and tx, is macromyst(gastric Lavage) |
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Definition
| toxicity from nonsalycitates (acetaminaphen) effects what organ and what is the tx? |
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Term
charchole
and gastric lavage |
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Definition
| what is the tx for salicylate overdose? |
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Term
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Definition
| morphine, codine, hydrochlorides are all? |
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Term
| synthetic narcotic agents |
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Definition
| methadone, levorphanol, and remifentanil are all? |
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Term
| analgesic, antipyretic,and anti inflammatory |
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Definition
| phamscological effectsof NSAIDS? |
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Term
| patient controlled anagesic |
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Definition
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Term
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Definition
| Has a Long lasting and systemic effect |
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