Term
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Definition
| What drug binds to cellular receptors and activate the JAK-STAT signal transduction pathway to inhibit protein synthesis? |
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Term
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Definition
| Which drug is used for genital warts, hepatitis B, C, Kaposi's Sarcoma, and MS? |
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Term
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Definition
| Which two drugs are used in combo for the standard treatment of Hep C? |
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Term
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Definition
| Giving IFNa which way induces flu-like symptoms? |
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Term
| mouth, face, skin, esophagus, brain |
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Definition
| Where is HSV 1 usually located on the body? |
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Term
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Definition
| Which type of HSV is found in the genitals, rectum, skin hands and meninges? |
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Term
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Definition
| Which drug has the viral thymidine kinase which leads to premature chain termination? |
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Term
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Definition
| What is the inital treatment for herpes infections? |
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Term
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Definition
| Which two ways is Acyclovir administered? |
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Term
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Definition
| Gancyclovir competitively inhibits viral DNA polymerase to block ________? |
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Term
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Definition
| Which drug is used to treat cytomegalic retinitis in immunocomprimised pts and CMV in transplant pts? |
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Term
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Definition
| Is Gancyclovir more or less potent than Acyclovir? |
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Term
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Definition
| Which drug has these SE: dose-dependent neutropenia, CNS effects, & may be carcinogenic? |
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Term
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Definition
| On what drug will pts present with blurred vision, floaters, or loss of central or peripheral vision? |
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Term
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Definition
| What drug has the MOA that REVERSIBLY inhibits viral DNA & RNA polymerases? |
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Term
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Definition
| Which drug do you give if your pt has cytomegalic retinitis and is resistant to Gancyclovir? |
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Term
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Definition
| Which drug do you give to a pt who has herpes and is resistant to Acyclovir? |
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Term
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Definition
| Which drug is more toxic, Gancyclovir or Foscarnet? |
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Term
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Definition
| What is a major SE of Foscarnet? |
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Term
|
Definition
| Which drug is used to treat primary keratoconjuctivitis and recurrent epithelial kerititis? |
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Term
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Definition
| Which drug replaced the drug Idoxuridine? |
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Term
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Definition
| Which drug is used topically to treat kerititis? |
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Term
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Definition
| Which drug has the MOA of inhibiting viral DNA synthesis making it more susceptible to breaks which leads to error-prone transcription? |
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Term
| neuraminidase inihibitors |
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Definition
| Which type of drugs are used to treat viral respiratory infections? |
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Term
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Definition
| Which type of drugs decrease the release of virus from infected cells, increasing the formation of viral aggregates and therefore decreasing viral spread? |
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Term
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Definition
| What are Neuraminidase inhibitors active against? |
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Term
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Definition
| What type of drugs are the recommended tx of H1N1? |
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Term
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Definition
| Which drug must you give within 30 hrs of onset of flu symptoms? |
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Term
|
Definition
| which drug must you give within 36 hrs of onset of flu symptoms? |
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Term
| nasal & throat discomfort, bronchospasms in asthma pts |
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Definition
| What SE is common with Zanamivir? |
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Term
|
Definition
| Which drug alters the intracellular nucleotide pools and inhibits viral mRNA synthesis? |
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Term
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Definition
| What drug, when given aerosol, may cause conjuctival irritation and transient wheezing? |
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Term
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Definition
| Which drug is given as an aerosol to treat infants with RSV infections? |
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Term
| Nucleoside Reverse Transcriptase Inhibitors (NRTI's) |
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Definition
| Which type of drugs must be converted to their nucleotide form to be effective? |
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Term
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Definition
| AZT effects ____ ______ more than cellular replication. |
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Term
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Definition
| Which drug is used for pregnant HIV pts that protects the fetus from becoming infected? |
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Term
PAL I Care:
Probenicid
Acetaminophen
Lorazepam
Indomethacin
Cimetidine |
|
Definition
| Which 5 drugs increase the toxicity of AZT? |
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Term
|
Definition
| What is a major SE of AZT? |
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Term
|
Definition
| If a reverse transcripatse becomes mutated, what will happen? |
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Term
| Zidovudine, Abacavir, Lamivudine |
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Definition
| Which 3 drugs are combined to make Trizivir? |
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Term
|
Definition
| NRTI's inhibits reverse transcriptase and terminates DNA chain ___________? |
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Term
|
Definition
| What drug is given to pts with AZT resistant HIV infections? |
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Term
| pancreatitis & Portal HTN |
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Definition
| What is are 2 major SE of Didanosine? |
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Term
|
Definition
| Toxicity increases when _______ is combined with Stavudine. |
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Term
|
Definition
| What 2 drugs can you combine with AZT? |
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Term
|
Definition
| What drug has the SE: peripheral neuropathy, stomatitis and rash? |
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Term
| Stavudine & AZT (Zidovudine) |
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Definition
| Which two drugs have the SE: fatal lactic acidosis, peripheral lipoatrophy, central fat accumulation & hyperlipidemia? |
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Term
|
Definition
| Which two drugs are used to treat chronic Hep B infections? |
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Term
|
Definition
| Use of which drug produces pancreatitis in peds pts? |
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Term
| Abacavir (this makes Trizivir) |
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Definition
| Which drug is given with Zidovudine & Lamivudine to treat HIV? |
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Term
|
Definition
| What is the NtRTI would you never give with Didanosine, Lamivudine, or Abacavir? |
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Term
|
Definition
| Which drug binds NEXT to the reverse transcriptase activation site altering the conformation? |
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Term
|
Definition
| Which two drugs are used in combo with Efavirenz? |
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Term
|
Definition
| Which drug has the SE of nightmares and hallucinations? |
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Term
|
Definition
| Which disease do you not give Efavirenz with as it may produce a hypersensitivity reaction? |
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Term
|
Definition
| What is the single pill that contains Efavirenz, Emtricitabine and Tenofovir? |
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Term
|
Definition
| What two drugs can you give with Nevirapine? |
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Term
|
Definition
| St. John's Wart causes a drug interaction with which drug? |
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Term
|
Definition
| Nevirapine should never be administered with which two drugs? |
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Term
Ethinylestradiol
*give other birth control |
|
Definition
| Nevirapine decreases plasma concentrations of what other drug? |
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Term
|
Definition
| Which two drugs do you use in combo with Delaviridine? |
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Term
|
Definition
| Rash is less frequent with which NNRTI? |
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Term
|
Definition
| What type of drugs interfere with the proteolysis of the gag-pol precursor and lead to nonfunctional virions? |
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Term
|
Definition
| HIV pts must take which type of drugs continuously with AZT and Lamivudine? |
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Term
|
Definition
| Which drug is taken orally once per day and has less of an effect on the patient's lipid profile? |
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Term
|
Definition
| Which drug combination is used to treat HIV strains that are resistant to protease inhibitors? |
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Term
|
Definition
| Cross resistance does not cocur with HIV pts with this drug. |
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Term
|
Definition
| Which drug binds to the glycoprotein and prevents the conformational change in HIV? |
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Term
|
Definition
| Which drug blocks the CCR5 chemokine receptor? |
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Term
|
Definition
| Which fusion inhibitor causes these SE: cough, fever, dizziness, HA, decreased BP, nausea & bladder irritation? |
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Term
|
Definition
| Which suffix is used for DNA viruses? |
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Term
|
Definition
| Which suffixes are used for RNA viruses? |
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