Term
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Definition
| reflectx affinity of the enzyme for its substrate |
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Term
|
Definition
| directly proportional to the enzyme concentration |
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Term
|
Definition
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Term
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Definition
|
|
Term
| the further the right the x intercept what happens to Km? |
|
Definition
| greater and thus lower affinity |
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Term
| competitive vs noncompetitive: resembles substrate |
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Definition
|
|
Term
| competitive vs noncompetitive: doesn't resemble substrate |
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Definition
|
|
Term
| competitive vs noncompetitive: overcome by increased [] |
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Definition
|
|
Term
| competitive vs noncompetitive: not overcome by increased [S] |
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Definition
|
|
Term
| competitive vs noncompetitive: binds active side |
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Definition
|
|
Term
| competitive vs noncompetitive: binds other site |
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Definition
|
|
Term
| competitive vs noncompetitive: no change of v max |
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Definition
|
|
Term
| competitive vs noncompetitive: decreases Vmax |
|
Definition
|
|
Term
| competitive vs noncompetitive: increases Km |
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Definition
|
|
Term
| competitive vs noncompetitive: no change in Km |
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Definition
|
|
Term
| competitive vs noncompetitive: decreases potency |
|
Definition
|
|
Term
| competitive vs noncompetitive: decreases efficacy |
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Definition
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Term
|
Definition
| amount of drug in body / plasma [drug] |
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Term
|
Definition
| distribute to blood, large or charged |
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Term
|
Definition
| distribute to extracelluar space/body water, small hydrophilic and do not bind plasma proteins |
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Term
|
Definition
| distribute to all tissues, small lipophilic and bind to extravascular proteins |
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Term
|
Definition
| rate of elimination of drug / plasma [drug] |
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Term
|
Definition
| time required to change amount of drug in the body by 1/2 |
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|
Term
| 1st or 0 order for half life? |
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Definition
|
|
Term
| half lives to reach steady state |
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Definition
|
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Term
|
Definition
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Term
|
Definition
| fraction of administered drug that reaches circulation, IV = 100% |
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Term
|
Definition
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|
Term
|
Definition
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Term
|
Definition
| max effect a drug can produce; Km; analgesic meds, antibiotics, antihistamines, decongestants |
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Term
|
Definition
| amount of drug needed for a given effect, Km; chemotherapy, antihypertensive, anti lipid drugs |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| down and either left or right |
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|
Term
| Therapeutic index equation |
|
Definition
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|
Term
| safer drugs have high or low TI? |
|
Definition
|
|
Term
| constant amount is eliminated |
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Definition
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|
Term
| examples of zero order drugs |
|
Definition
| phenytoin, ethanol and ASA |
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|
Term
| rate of elimination is constant fraction |
|
Definition
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|
Term
| enviroment WA get trapped |
|
Definition
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|
Term
|
Definition
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|
Term
| WB trapped in what kind of environment |
|
Definition
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|
Term
|
Definition
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|
Term
| yields slightly polar, water soluble |
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Definition
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|
Term
| polar inactive metabolites |
|
Definition
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|
Term
|
Definition
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|
Term
| phase 1 or 2: conjugation |
|
Definition
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|
Term
| phase 1 or 2: lose first in elderly |
|
Definition
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Term
|
Definition
| glucuronidation, acetylation and sulfation |
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