Term
| Tacrine is what kind of drug in the tx of Alzheimer's Dz? |
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Definition
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Term
| Donezepil is what kind of drug in the tx of Alzheimers? |
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Definition
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Term
| memantine is what kind of drug in the tx of alzheimers? |
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Definition
| NMDA receptor antagonists |
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Term
| T or F. AChE inhibitors do not alter the course of Alzheimers? |
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Definition
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Term
| Mechanism of action: tacrine and donezepil |
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Definition
| increase level of ACh and it's cholinergic neurons that originate in the basal forebrain and innervate the cortex and hippocampus that degenerate the 1st in this dz |
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Term
| How do NMDA receptors play a role in Alzheimers? |
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Definition
| excessive activity may contribute to neuronal death via chronic calcium loading; but some activation is necessary for normal cognitive function |
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Term
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Definition
| a moderate affinity, non-competitive ANTAGONIST of NMDA receptor that blocks pathological but not physiological activation of NMDA receptor |
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Term
| T or F: memantime may reduce rate of clinical deterioration of alzheimer patients |
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Definition
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