Term
| Mechanism of Action (MOA) |
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Definition
| -manner in which molecular targets are affected by the drug. |
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Term
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Definition
| -the binding of the drug at the receptor is followed by a series of signal transduction events which result in end points. |
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Term
| Mechanism of Action (MOA) |
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Definition
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Term
| Mechanism of Action (MOA) |
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Definition
| -example: morphine binding to and activating μ GCPRs in the brain. |
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Term
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Definition
| -what the drug does to the body. |
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Term
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Definition
| -example: morphine causing analgesia in the body. |
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Term
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Definition
| -predictable reactions that are bothersome. |
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Term
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Definition
| -causes the patient to stop taking that drug. |
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Term
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Definition
| -medications and health conditions that pose considerable risk. |
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Term
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Definition
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Term
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Definition
| -minimum to maximum dose. |
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Term
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Definition
| -the physical state of the drug delivered. |
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Term
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Definition
| -the concentration of the drug when it elicits 50% of its maximum response. |
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Term
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Definition
| -elicits a response from the tissue. |
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Term
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Definition
| -drug with the greatest pharmacological effect. |
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Term
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Definition
| -effects are less than the full agonist. |
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Term
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Definition
| -causes the opposite effect of the agonist. |
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Term
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Definition
| -prevents the activity of the agonist. |
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Term
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Definition
| -binds at the same site receptor as the agonist. |
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Term
| Non-competitive Antagonist |
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Definition
| -binds at a different site than the agonist. |
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Term
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Definition
| -can bind at a different site than the agonist even when the agonist is bound. |
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Term
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Definition
| -tendency to bind to receptors. |
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Term
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Definition
| -ability to initiate a response. |
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Term
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Definition
| -capacity of a single drug-receptor complex to evoke a response. |
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Term
| Allosteric Model of Drug Action |
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Definition
| -receptors exist in more than one configuration and can be induced to fit or inhibited to inactivate. |
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Term
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Definition
| -transfer of drug from its site of administration to the blood. |
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Term
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Definition
| -transfer of drug from blood to tissue. |
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Term
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Definition
| -enzymatic conversion of drugs to more polar compounds. |
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Term
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Definition
| -removal of drugs from the body. |
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Term
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Definition
| -drugs consumed via inhalation, intranasal, topical, transdermal, ocular, etc. |
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Term
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Definition
| -the concentration of a drug is decreased when metabolized in the liver before reaching systemic circulation, but can be reintroduced to the GI tract again. |
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Term
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Definition
| -fraction of unchanged drug that reaches the systemic circulation following administration by any route. |
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Term
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Definition
(drug in system)
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(drug administered) |
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Term
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Definition
| -indicator of how drugs are dispersed among the body compartments. |
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Term
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Definition
| -time for the plasma concentration of a drug to be reduced by 50%. |
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Term
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Definition
| -the process of a drug inducing more enzymes to be produced by the liver for faster metabolism. |
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Term
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Definition
| -the unavailability of an enzyme to metabolize a drug because it is already metabolizing another drug. |
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Term
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Definition
(lethal dose in 50%)
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(effective dose in 50%) |
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Term
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Definition
| -takes biological diversity into account by using the lethal dose in 1% instead of 50%. |
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Term
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Definition
(lethal dose in 1% - effective dose in 99%)
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(effective dose in 99% x 100) |
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Term
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Definition
| -the range of the concentration of plasma with a drug having high probability of therapeutic success. |
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Term
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Definition
| -two drugs oppose each other in their pharmacological effects. |
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Term
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Definition
| -combination results in an effect of one that is greater than expected. |
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Term
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Definition
| -additive effects of two drugs that share the same pharmacological effects. |
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Term
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Definition
| -the combination of drugs results in pharmacological effects that are greater than the maximum effect of each individual drug. |
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