Term
|
Definition
| mediator of inlfammatory reactions associated with type 1 hypersensitivity |
|
|
Term
|
Definition
| plasma membrane proteins to which HA binds to cause inflammatory changes. H1, H2. |
|
|
Term
|
Definition
| allergic reactions, vasodilation, increased permeability |
|
|
Term
|
Definition
| vasodilation, stomach acid secretion |
|
|
Term
| 1st generation antihistamine |
|
Definition
| 1st generation bind to H1 and H2 receptors. Lipophillic, Antichilinergic. |
|
|
Term
|
Definition
| less CNS effects and anticholinergic effects. Bind only to H1 |
|
|
Term
| Pharamacotherapeutics of Antihistamines (1st generation & 2nd generation) |
|
Definition
| type 1 hypersensitivity reactions, hives. |
|
|
Term
| Pharmacotherapeutics of Antihistamines (1st only) |
|
Definition
| anaphylactic reactions, rhinitis, motion sickness, OTC sleep aids, common cold rhinorrhea and sneezing. |
|
|
Term
| Drug interactions of Antihistamines |
|
Definition
| 1st generation: anitcholinergics, CNS depressants, MAO inhibitors, antacids, alcohol. 2nd generation: CNS depressants, alcohol. |
|
|
Term
| 1st generation anithistamines |
|
Definition
| diphenhydramine (benadryl), chlorpheniramine maleate(chlortrimeton) |
|
|
Term
| 2nd generation Antihistamines |
|
Definition
| loratadine(claritin), fexofenadine (allegra), cetirizine (zyrtec). |
|
|
Term
|
Definition
| enzyme that converts arachidonic acid to prostaglandin |
|
|
Term
|
Definition
| PG functions to increase platelet aggregation, protect GI mucosa, vasodilation in kidney. |
|
|
Term
|
Definition
| PG fnctions to regulate pain transmission and fever, causes vascular vasodilation and decrased platelet aggregation, regulates fluid/electrolytes in kidney |
|
|
Term
| Immunosuppressants List Them |
|
Definition
| Imuran, Azasan, Sandimmune, Neoral, Prograf, Prednisone |
|
|
Term
|
Definition
| inhibit COX-1 and COX-2. Decrased platelet aggregation. bleeding tendencies. acute renal failure. GI erosion and ulceration. Anti-inflammatory, analgesic, reduce fever. |
|
|
Term
|
Definition
| inhibit COX-2 only. analgesic. reduce fever. Less GI effects. No protective benefit for MI and CVA. |
|
|
Term
|
Definition
| 1st generation: GI, renal, liver, increased bleeding time. 2nd generation: increased risk of MI and CVA. |
|
|
Term
|
Definition
| 1st generation Salicylates: Aspirin, Propionic Acids: Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Indomethacin, Nabumetone. 2nd generation: celecoxib, rofecoxib, valdecoxib. |
|
|
Term
| Pharmacodynamics of Steroidals |
|
Definition
| Inhibit chemical mediator synthesis. suppress inflitration of phagocytes, suppress proliferation of lymphocytes. |
|
|
Term
| Pharmacotherapeutics of Steroidals |
|
Definition
| Adrenal Insufficiency, Acute SCI, CVA, TBI, MS, Allergic reactions, atuoimmune diseases, inflammatory conditions, organ transplants. |
|
|
Term
|
Definition
| Cushingoid features, Nervous System, Fluid and electrolyte imbalances, Skin. |
|
|
Term
| Drug-drug & drug-herbal interactions of Steroidals |
|
Definition
| diuretics, insulin, NSAID, Echinecea. |
|
|
Term
|
Definition
| cortisone acetate, dexamethasone, fluticasone, hydrocortisone, methylprednisolone, prednisone, bludesonide. |
|
|
Term
| Disease Modifying Anti Rheumatic Drugs |
|
Definition
| Pills: Methotrexate, Leflunomide, Hydroxychloroquine, Sulfasalazine. Shots: Adalimumab Humira, Anakinra Kineret, Etanercept Enbrel. IV: Abatacept Orencia, Infliximab remicade, Rituximab Rituxan. |
|
|
Term
| Order of treatment of DMARDS |
|
Definition
| NSAIDS, Corticosteroids. Initiate DMARDS. TNF Blockers. |
|
|
