Term
| Deficiency of this is thought to be the cause of depression |
|
Definition
|
|
Term
| It takes about 14 days to see changes in mood after taking antidepressants because this is the thing we are targetting |
|
Definition
| Levels of monoamine receptors |
|
|
Term
| These receptors are particularly implicated in depression |
|
Definition
| 5HT2 and alpha and bets adrenoceptors |
|
|
Term
| Tricyclic antidepressants (TCAs) block the reuptake of this |
|
Definition
|
|
Term
| Tricyclic antidepressants (TCAs) more favourably block the reuptake of this |
|
Definition
|
|
Term
|
Definition
| Blockade of muscarinic receptors - dry mouth, blurred vision, urine retention |
|
|
Term
|
Definition
| Blockade of H1 receptors - sedation |
|
|
Term
|
Definition
| Blockade of a1-adrenoceptors - orthostatic hypotension |
|
|
Term
|
Definition
|
|
Term
| SSRIs specifically block the reuptake of this |
|
Definition
|
|
Term
|
Definition
| Anxiety (initially, down regulated over time) |
|
|
Term
|
Definition
| Nausea, vomiting, GI disturbances, anxiety |
|
|
Term
|
Definition
|
|
Term
| First line treatment for depression |
|
Definition
|
|
Term
| Useful for anxiety, panic disorders, pohbias, OCD, eating disorders |
|
Definition
|
|
Term
| This enzyme is associated with depression |
|
Definition
|
|
Term
| This enzyme is associated with Parkinson's |
|
Definition
|
|
Term
| This enzyme is associated with Parkinson's |
|
Definition
|
|
Term
| Preferred substrate for MAOa |
|
Definition
|
|
Term
| Preferred substrate for MAOb |
|
Definition
|
|
Term
| Are non-selective inhibitors used for depression |
|
Definition
|
|
Term
|
Definition
| Insomnia, postural hypotension, atropine-like side effects, sexual dysfunction |
|
|
Term
| Most commonly used treatment for depression |
|
Definition
|
|
Term
| You will get a cheese reaction with this |
|
Definition
|
|
Term
| This monoamine found in cheese can cause hypertensive crisis if on MAOIs |
|
Definition
|
|
Term
| Tyramine is able to displace large quantities of this |
|
Definition
|
|
Term
| These reversibly bind to MAO |
|
Definition
|
|
Term
| You will NOT get a cheese reaction with this |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Useful to treat anxiety, panic, phobia |
|
Definition
|
|
Term
| This system is the most common method of terminating the action of transmitter at the receptor |
|
Definition
| Removal of transmitter by a transporter |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Fastest type of neurotransmitters |
|
Definition
| Type I - glutamate, glycine, GABA |
|
|
Term
| Most common type of neurotransmitters |
|
Definition
| Type I - glutamate, glycine, GABA |
|
|
Term
| Type II neurotransmitters |
|
Definition
| Catecholamines, amines, purines |
|
|
Term
| Type II neurotransmitters |
|
Definition
|
|
Term
| Slower/middle type of neurotransmitters |
|
Definition
| Type II - catecholamines, amines, purines |
|
|
Term
| Type III neurotransmitters |
|
Definition
|
|
Term
| Type III neurotransmitters |
|
Definition
| Endogenous opioids, pituitary hormones, hormone release factors, brain peptides (substance P) |
|
|
Term
| Slowest type of neurotransmitters |
|
Definition
|
|
Term
| Receptors associated with type I neurotransmitters (simple amino acids) |
|
Definition
|
|
Term
| Receptors associated with type II and III neurotransmitters |
|
Definition
|
|
Term
| Binding of neurotransmitter to this type of receptor in the CNS stimulates entry via ligand gated receptor ion channel |
|
Definition
|
|
Term
| Binding of neurotransmitter to this type of receptor in the CNS stimulates the production of a second messenger via a G-protein |
|
Definition
|
|
Term
| The actions of DA, NA, and 5HT are terminated in this manner |
|
Definition
| Via specific transporters for each transmitter at the nerve terminal |
|
|
Term
| These enzymes degrade the monamines - DA, NA, 5HT |
|
Definition
|
|
Term
| This enzyme degrades NA and 5HT |
|
Definition
|
|
Term
|
Definition
|
|
Term
| This monoamine is associated with transmission of sensory information to higher CNS areas, hallucinations, and anxiety |
|
Definition
|
|
Term
| 5HT is taken up by this transporter |
|
Definition
| Serotonin transporter (SERT) |
|
|
Term
| NA is taken up by this transporter |
|
Definition
| Noradrenaline transporter (NT) |
|
|
Term
| Activation of dopinergic neurons in the brain is associated with these two effects |
|
Definition
|
|
Term
| The dopamine pathway that is associated with behaviour |
|
Definition
| Mesocortical/mesolimbic pathway |
|
|
Term
| The dopamine pathway that is associated with fine motor control |
|
Definition
|
|
Term
| Delusions, and auditory hallucinations are these type of symptoms |
|
Definition
|
|
Term
| Social withdrawal, lack of drive, and blunting of emotions are these type of symptoms |
|
Definition
|
|
Term
| Lack of attention, deficits in memory, and problems with executive function are the type of symptoms |
|
Definition
|
|
Term
| These are used as anitpsychotics |
|
Definition
|
|
Term
| These are used in Parkinson's |
|
Definition
|
|
Term
| D2 antagonists are used on this pathway as antipsychotics |
|
Definition
| Mesocortical/mesolimbic system |
|
|
Term
| D2 agonists are used on this pathway to treat Parkinson's |
|
Definition
|
|
Term
| Activation of these neurons is associated with cognition memory and learning |
|
Definition
|
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