Term
|
Definition
| Cholinesterase inhibitor (anticholinesterase), inc. Ach, for alzheimers and MG |
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Term
|
Definition
| muscarinic receptor antagonist, to dilate eye |
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Term
|
Definition
| Non-catecholamine, adrenergic agonist, for anaphylactic shock and acute asthma attacks, [nonspec], G(q)>Ca>contraction |
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Term
|
Definition
| non-catecholamine adrenergic agonist, for vasoconstriction, shock [alpha 1 rec] |
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Term
|
Definition
| For asthma, adrenergic agonist [beta 2 rec] |
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Term
|
Definition
| non-catecholamine adrenergic agonist, for weight loss |
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Term
methylphenidate
[what pathology is it used for?] |
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Definition
| non-catecholamine adrenergic agonist, for narcolepsy |
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Term
|
Definition
| catecholamine adrenergic agonist, for bronchodilation |
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Term
|
Definition
| catecholamine adrenergic agonist, for bronchodilation |
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Term
| phenoxybenzamine, phentolamine |
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Definition
| alpha blocker, acts against epi, to vasodilate, for adrenal tumors |
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Term
|
Definition
| alpha blocker [alpha 1], vasodilates to treat hypertension, promote urine for BPH |
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Term
| propranolol (in adrenergic drugs) |
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Definition
| beta blocker, to treat angina and decreases HR and oxygen consump., txt hypertension too |
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Term
|
Definition
| diuretic, carbonic anhydrase inhibitor, blocks NaHCO3 reabs. |
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Term
|
Definition
| diuretic, osmotic agents, prevents water reabs. at proximal tubule |
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Term
|
Definition
| loop diuretic, blocks NKCC2 channels, so Na, Cl, K can't be reabs. [TAL] |
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Term
|
Definition
| thiazide, NCC blocker, inh. of Na and Cl reabs., can reabs. Ca++ |
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Term
|
Definition
| K sparing diuretic in [CT], inh. translocation of receptor for aldosterone transcription |
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Term
|
Definition
| K sparing diruetic, prevents ENaC act. and Na reabs. |
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Term
|
Definition
| ADH antagonist, receptor antagonist, for euvolemic hyponatremia |
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Term
| tolvaptan, lixivaptan, -vaptans |
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Definition
| ADH antagonists, for SIADH |
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Term
|
Definition
| HMG analog, a HMG CoA reductase inh. to stop de novo cholesterol syn., cell inc. LDL-R |
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Term
| cholestryamine, colestipol |
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Definition
| pos. charged resin to sequester bile acids., inc. LDL-R in liver |
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Term
|
Definition
| dec. LDL [ ] and inc. HDL; inh. FA breakdown, so dec. TGA |
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Term
|
Definition
| inhibit PPAR alpha TF expression, inc. LPL, inc. HDL |
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Term
|
Definition
| inh abs. of cholesterol from SI, limited effects |
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Term
|
Definition
| calcium channel blockers, to relax VSM |
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Term
| minoxidil, hydraazine, diazode |
|
Definition
| K channel openers, desensitive to calcium, to vasodilate, stabilizes resting membrane pot. |
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Term
| (clonidine)guanabenz, alpha methyl dopa |
|
Definition
| alpha 2 agonist, a sympathoplegic agent that centrally acts on SNS inh. |
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|
Term
| propranolol (in cardiotherapeutics) |
|
Definition
| beta blocker, to dec. C.O. and BP, inc. TPR. |
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Term
|
Definition
| vasodilating beta receptor antagonist, lower BP, dec C.O., inc. TPR |
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Term
|
Definition
| ACE inhibitor, inh. AII production, causes vasodilation, inc bradykinin |
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Term
|
Definition
|
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Term
|
Definition
| inc. C.O. for HF; inh. Na/K ATPase, so more Ca stays in for contractility |
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Term
|
Definition
| cardiac glycoside, inotropic agents, inh. Na/K ATPase so Ca stays in cell and inc. contractility. Inc. C.O. for HF |
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|
Term
| dopamine (in cardiotherapeutics) |
|
Definition
| short term inotrope to inc. C.O. in HF. Acts on beta adrenergist as agonist like epi, NE and AII |
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Term
| inamrinone, milrinone (amrinone) |
|
Definition
| cAMP PDE inhibitor, inc. cAMP to inc. intracellular Ca for contractility, for HF |
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Term
|
Definition
| binds onto calcineurin to inhibit NFAT and subsequent IL-2 transcription |
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Term
|
Definition
| binds onto calcineurin and prevents NFAT from transcription of IL-2 |
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Term
|
Definition
| mTOR inhibitor ie. rapamycin, prevents transcription of proteins that proliferate immmune cells |
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Term
|
Definition
| Purine nt analog, affects lymphocytes because of their purine salvage pathway |
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Term
|
Definition
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Term
|
Definition
| Ab specific to lymphocyte surface cell receptor |
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Term
|
Definition
| Ab against CD25 IL-2 rece. on activated lymphocyte |
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Term
|
Definition
| antibody against CD3 of TCR on lymphocytes |
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Term
|
Definition
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Term
|
Definition
| protein against TNF alpha |
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Term
| cortisol (in immunosuppressive therapy) |
|
Definition
| binds to glucosteroid and prevents transcription of IL-2, IL-1, IFN, TFNa |
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Term
|
Definition
| binds onto glucosteroid but doesn't allow transcription after dimerization |
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Term
|
Definition
| reduces degranulation of mast cells and eiosinophils |
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Term
|
Definition
| histamine receptor inverse agonists |
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Term
|
Definition
| histamine receptor inverse agonists |
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Term
|
Definition
| histamine receptor inverse agonist |
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Term
|
Definition
| 2nd generation antihistamine, zyrtec |
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Term
|
Definition
| 2nd generation antihistamine, claritin |
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Term
|
Definition
| 2nd generation antihistamine, allegra |
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Term
|
Definition
| h2 receptor inverse agonist, zantac |
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Term
|
Definition
| h2 receptor inverse agonist, pepcid |
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Term
|
Definition
| h2 receptor inverse agonist, tagamet |
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Term
| albuterol, pirbuterol, terbutaline |
|
Definition
| short acting beta 2 agonist, relaxes SVM around bronchioles |
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Term
|
Definition
| long acting beta 2 receptor agonist, lipophilic so stays in membrane longer, bronchodilation |
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Term
|
Definition
| anti muscarinic for bronchodilation |
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Term
|
Definition
| bronchodilating methylxanthine, relaxes SVM, inhibit PDE and inc. cAMP |
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Term
| ciclesonide (and most -sones) |
|
Definition
| anti-inflammatory corticosteroid for asthma |
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|
Term
cromolyn and nedocromil (for asthma)
[what are the effects on airway?]
[when do asthamatics use it?]
[mechanism?] |
|
Definition
| prophylactic for asthmatics, inhibits airway nerves, delays Cl channels to prevents degranulation |
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Term
|
Definition
| 5-LOX inhibitor, arachidonic acid can't convert to LTA |
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Term
|
Definition
| 5-LOX inhibitor, arachidonic acid can't convert to LTA, antiinflammatory |
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Term
|
Definition
| Blocks LTD and CysLT receptor interaction, anti-inflammatory |
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Term
|
Definition
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Term
|
Definition
| antacid, weak base, most efficient |
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Term
| famotidine, ranitidine, cimetidine (in GERD and GI) |
|
Definition
| H2-receptor blockers, prevent gastric acid secretion |
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Term
|
Definition
| PPI, binds reversible to H/K ATPase [esomeprazole=nexium) |
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Term
|
Definition
| increases promotility in GI, increase LES pressure, dopamine receptor antagonist |
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Term
| lispro, aspart, glulisine |
|
Definition
| short acting insulin (rapid) |
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Term
| NPH insulin, lente, isophane |
|
Definition
| intermediate acting insulin |
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Term
|
Definition
| basal insulin, long lasting |
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Term
|
Definition
| a biguanide, lowers livers resistance to insulin so doesn't make glucose |
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Term
|
Definition
| depolarizes beta cells to increase insulin secretion |
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Term
|
Definition
| bind PPAR gamma, transcription of proteins that increase insulin actions, "inc. insulin sensitivity" |
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|
Term
| roseglitazones, pioglitazone |
|
Definition
| increase insulin's activities, "increase insulin sensitivity" [types of thiazolidinediones] |
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Term
|
Definition
| anticoagulant, accelerates intx w/ antithrombin with thrombin |
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Term
|
Definition
| binds to factor Xa, inhibition of thrombin through allosteric mech. |
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Term
|
Definition
| uses scaffold mech to make trimolecular complex |
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Term
|
Definition
| binds directly to thrombin, derived from leech saliva |
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Term
|
Definition
| binds directly to thrombin to anticoagulate |
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Term
|
Definition
| oral anticoagulant, inhibit vitamin K dependent clotting factors |
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Term
|
Definition
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Term
|
Definition
| inh. pG metabolism, inhibits COX (arachdonic acid to pG), sustains antithrombotic effects |
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Term
|
Definition
| Ab agonist against GPIIb/IIIa, preventing firbinogen from binding |
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Term
|
Definition
| prevents binding of ADP to cell receptor, so GPIIb/IIIa can't be activated |
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Term
|
Definition
| bind to GPIIb/IIIa receptor as competitive inhibitor |
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Term
|
Definition
| LAAD inhibitor (prevents degradation into peripheral circulation) |
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Term
|
Definition
| exogenous precursor to dopamine for parkisons |
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Term
|
Definition
| MAO inhb., retards breakdown of dopamine for parkinsons |
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Term
|
Definition
| COMT inhibitor, prevents competition of dopamine to brain for parkinsons |
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Term
|
Definition
| dopamine agonist for parkinsons, of "off" periods |
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Term
|
Definition
| dopaminergic agonist for parkinsons, transdermal patch |
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Term
|
Definition
| toxic dopaminergic agonist for parkinsons |
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Term
|
Definition
| dopaminergic agonist, to use as monotherapy for parkinsons (don't use w/ cimetidine) |
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Term
|
Definition
| antiviral- inh. NMDA to inc. dopamine secretion |
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Term
|
Definition
| antimuscarinic for parkinsons |
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Term
|
Definition
| antimuscarinic agent for parkinsons |
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Term
|
Definition
| antimuscarinic agent for parkinsons |
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Term
|
Definition
| antimuscarinic agent for parkinsons |
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|
Term
| tacrine (for txt of neurological disorder) |
|
Definition
| Ach-ase inh. for alzheimers |
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Term
|
Definition
| NMDA receptor antagonist for alzheimers, to prevent excitotoxic activity from too much glutamate recept. activity |
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Term
|
Definition
| dopaminergic agonist, to use as monotherapy for parkinsons (don't use w/ cimetidine) |
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Term
|
Definition
|
|
Term
|
Definition
| estrogen & progestin HRT, for endometrial hyperplasia, prevent osteoporosis |
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Term
| mestranol and ethinyl estradiol (EE) |
|
Definition
hormonal contraception, mestranol is inactive prodrug of EE
EE used as patch |
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|
Term
| etonogesterl, levonogesterel |
|
Definition
| progestin only contraceptive |
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|
Term
| norethindrone, drospirenone |
|
Definition
| progestin only contraception |
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|
Term
| depo provera, nuva ring, mirena |
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Definition
|
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Term
|
Definition
| antiprogestin emergency contraceptive, abortive |
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Term
|
Definition
| SERM-for breast cancer, for bone reabsorption (estrogen receptor modulants) |
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Term
|
Definition
| weak androgen, for endometriosis |
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Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
| antiestrogen, analog of E2 |
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Term
|
Definition
blocks estrogen secretion
ovulation inducing, txt for PCOS |
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|
Term
| methyltestoerone, fluoxymesterone, oxandrolone |
|
Definition
| testosterone derivatives, 17 a alkylated androgens, to reduce breast engorgement and tumors |
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Term
| abarelix, degarelix, cetrorelix, ganirelix |
|
Definition
| GnRH antagonists, for prostate cancer txt |
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Term
|
Definition
steroid synthesis inhibition
inhbits 17,20 desmolase
inhibits a lot of CYP450 |
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Term
|
Definition
| txt male pattern baldness, txt BPH |
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Term
|
Definition
synthesis inhibitor, 5a reductase inh
txt male pattern baldness, txt BPH |
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Term
|
Definition
5a reductase inh., synthesis inh.
txt male pattern baldness, txt BPH |
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Term
|
Definition
| steroid synthesis inhibition |
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Term
|
Definition
txt male pattern baldness, txt BPH
T synthesis inhibitor |
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Term
|
Definition
| steroid synthesis inhibition |
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Term
|
Definition
| txt male pattern baldness, txt BPH |
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|
Term
| flutamide, bicalutamide, nilutamide |
|
Definition
| androgen receptor antagonists, compete w/ T and DHT for AR binding |
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