Term
|
Definition
| diffuses into cns and is converted into dopamine to replace deficient dopamine |
|
|
Term
| side effects of carbidopa levidopa |
|
Definition
| GI:N&V,stimulates CTZ CV: hypotension, dysrhythmias, CNS: duskinesias, nervousness, confusion, vivid dreams, insomnia |
|
|
Term
|
Definition
| stimulates release of dopamine from nerve endings, increasing concentration (used in early stages of PD)also causes |
|
|
Term
| side effects of amantidine |
|
Definition
| Integument: red-purple skin blotches, livedo reticularis, GI, CNS: irritability, nervousness, confusion, MUSCARINIC BLOCKADE! |
|
|
Term
|
Definition
| act directly on dopamine receptors (mostly with D2 receptors)stimulating them (same side effects as levidopa) |
|
|
Term
|
Definition
| inhibits COMPT, which metabolizes dopamine, needs to be given with levodopa, similar side effects of dopamine (liver enzymes AST and ALT) |
|
|
Term
|
Definition
| inhibition of MAO-B enzyme which interferes with themetabolism dopamine |
|
|
Term
| MAO inhibitor drug interaction |
|
Definition
| Meperidine (causes stupor, rigidity, hyperthermia) |
|
|
Term
| Anticholinergic / Benztropine |
|
Definition
| blockade of muscarinic cholingergic receptors, good to control tremors in early stages |
|
|
Term
|
Definition
| *absolute avoidance of drugs that are dopamine blocking -> tricyclic antidepressants, phenothiazine antypsychotics |
|
|
Term
|
Definition
| Tremor, rigidity, akinasia and bradykinesia, postural instability |
|
|
Term
|
Definition
| supress nueronal discharge by supressing NA and CA influx, or potentiate GABA |
|
|
Term
|
Definition
| Supress Na influx, effects: CNS< GI, GINGIVAL HYPERPLASIA, skin rash,... INDUCER |
|
|
Term
| phenobarbital/antisiezure |
|
Definition
| potentiates GABA, barbituate, cns depression |
|
|
Term
| Carbemazepine/ antisiezure and adverse effects |
|
Definition
| supresses influx of NA, sedative, anticholingergic, antidepressant, muscle relaxer, adverse effects =nystagmus, heart failure, bp prob, arrthythmias, MI, anticholinergic, hematologic, INDUCER |
|
|
Term
| Valproic Acid/antisiezure |
|
Definition
| inhibits Ca influx, effects: GI, CNS, hepatic, hematologic |
|
|
Term
| treatment of status epilepticus |
|
Definition
| IV benzodiazepines (Diazepam/Valium) |
|
|
Term
| dantrolene/muscle relaxer |
|
Definition
| treats malignant hyperthermia, hepatotoxicity, CNS, GI |
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