Term
| common side effect of hypnotic agents |
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Definition
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Term
| occurs when sedative-hypnotics are used chronically or at high doses |
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Definition
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Term
| most common type of drug interaction of sedative hypnotics with other depressent meds |
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Definition
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Term
| major effect of BZs on sleep at high doses |
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Definition
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Term
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Definition
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Term
| BZs are used cautiously in pregnancy because... |
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Definition
| they can cross the placenta |
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Term
| main route of metabolism for BZs |
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Definition
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Term
| BZs that undergo extrahepatic metabolism, useful in oldies |
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Definition
| (LOT) lorazepam, oxazepam, temazepam |
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Term
| MOA for BZs vs barbiturates |
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Definition
| BZs extend frequency of GABA-mediated Cl- channel opening, barbiturates extend duration of channel opening |
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Term
| BZ antagonist, reverses CNS effects in overdose |
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Definition
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Term
| BZ with useful relaxant effects in skeletal muscle spasticity of central origin |
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Definition
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Term
| BZ with efficacy in absence seizures, anxiety states (i.e. agoraphobia) |
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Definition
| clonazepam (cALONEazepam; alone --> absence seizures) |
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Term
| most effective to treat panic disorders |
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Definition
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Term
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Definition
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Term
| DOC for status epilepticus |
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Definition
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Term
| longer-acting BZs used in treatment of withdrawal from alcohol/drugs |
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Definition
| chlordiazepoxide, diazepam |
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Term
| agents with active metabolites, long half lives, high incidence of adverse effects |
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Definition
| diazepam, flurapezam, chlordiazepoxide, clorazepate |
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Term
| barbiturates increase this condition |
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Definition
| acute intermittent porphyria |
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Term
| barbiturates decrease effectiveness of other drugs via this property |
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Definition
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Term
| barbiturates used for induction of anesthesia |
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Definition
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Term
| site of action for zaleplon and zolpidem |
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Definition
| BZ1 (benzodiazepine receptor) |
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Term
| good hypnotic activity with less CNS SE than BZs |
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Definition
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Term
| partial agonist for 5-HT1A receptor |
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Definition
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Term
| DOC for generalized anxiety disorder |
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Definition
| buspirone (not good for acute anxiety) |
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