Term
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Definition
| the conversion of energy from a noxious thermal, mechanical, or chemical stimulus into a nerve impulse via nociceptors |
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Term
| mediators that activate nociceptors |
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Definition
prostaglandins
cytokines
histamine
serotonin
substance P |
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Term
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Definition
| transduction, transmission, modulation, and perception |
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Term
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Definition
| impulses travel via axons of primary afferent neurons to the dorsal horn of the spinal cord |
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Term
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Definition
| nociceptive information is interpreted in the cerebral cortex in terms of location, intensity, and quality |
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Term
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Definition
| the attenuation of dorsal horn transmission by descending inhibitory input from the brain (supraspinal, spinal, and peripheral) |
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Term
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Definition
| pain from internal organs |
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Term
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Definition
| pain from skin, bone, muscle, tissue |
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Term
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Definition
| caused by aberrant signal processing in PNS or CNS - injury to nerves caused by metabolic disease, infection, tumor, toxin, etc; often unresponsive to NSAIDS or opiates |
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