Term
|
Definition
| receptors on GABA-Cl channel receptor complex increasing frequency of channel opening causing hyperpolarization |
|
|
Term
| side effects of all sleep BDZ |
|
Definition
tolerance develops fast
increase effect of alcohol
avoid in sleep apenea because it relaxes muscles of upper airway |
|
|
Term
|
Definition
| cannot initiate or maintain sleep (symptom not disease) |
|
|
Term
|
Definition
|
|
Term
| define circadian rhythm alteration |
|
Definition
| disturbance in sleep wake cycle (jet lag) |
|
|
Term
|
Definition
| dysfunction of sleep like partial arousal |
|
|
Term
| what are the stages of the sleep cycle, how long, how many |
|
Definition
stages 1-4: NREM
stage 5: REM
95 min each
4-5 per night |
|
|
Term
| what are the short acting sleep BDZ, how long |
|
Definition
3-8 hours
midazolam
triazolam |
|
|
Term
| what are the intermediate acting sleep BDZ, how long |
|
Definition
10-20 hours
temazepam
estazolam |
|
|
Term
| what are the long acting sleep BDZ, how long |
|
Definition
1-3 days
quazepam
fulrazepam |
|
|
Term
| side effects of short acting BDZ for sleep |
|
Definition
| Triazolam only: tolerance in days, withdrawl causes rebound |
|
|
Term
| side effects of long acting BDZ for sleep |
|
Definition
daytime sedation
hang over effect |
|
|
Term
| administration of midazolam |
|
Definition
|
|
Term
|
Definition
| peanecthetic and intraoperative medication (anterograde amnesia) |
|
|
Term
|
Definition
reoccuring insomnia
initiating sleep |
|
|
Term
| use of intermediate BDZ for sleep |
|
Definition
|
|
Term
| use of long BDZ for sleep |
|
Definition
reduce sleep
induration
decreasing waking
increase duration |
|
|
Term
| what type of drug is zolpidem |
|
Definition
| imidazopyridine derivative |
|
|
Term
|
Definition
binds to BDZ receptor at GABA-Cl channel causing hyperpolarization
does not affect different stages of sleep like BDZ or barbituiates |
|
|
Term
| what type od drug is zaleplon |
|
Definition
| pyrazolopurimidine derivative |
|
|
Term
|
Definition
binds to BDZ receptor at GABA-Cl channel causing hyperpolarization
does not affect different stages of sleep like BDZ or barbituiates |
|
|
Term
|
Definition
binds to BDZ receptor at GABA-Cl channel causing hyperpolarization
does not affect different stages of sleep like BDZ or barbituiates |
|
|
Term
|
Definition
melatonin receptor agonist
binds mT1 and MT2 receptors for melatonin |
|
|
Term
| what type of drug is chloral hydrate |
|
Definition
|
|
Term
|
Definition
| unknown activate metabolite trichloroethanol |
|
|
Term
|
Definition
minimal rebound insomnia and tolerance
sleep walking/activities, amnesia (increases with alcohol) |
|
|
Term
|
Definition
| minimal rebound insomnia and tolerance |
|
|
Term
|
Definition
|
|
Term
|
Definition
NO anoxiolytic, muscle relaxant, amnesic, or abuse potential
do not consume alcohol
decreased testosterone |
|
|
Term
|
Definition
sleep longer
jet lag
long term administration |
|
|
Term
|
Definition
sleep longer
long term use |
|
|
Term
|
Definition
difficulty initiating sleep
good for elderly |
|
|
Term
|
Definition
| sedation in kids (dental) |
|
|
Term
| which sleep medicine is not a controlled substance, why |
|
Definition
| ramelteon: no CNS depressiing |
|
|
Term
| which sleep medicine is affected by P450 inducers and inhibitors |
|
Definition
|
|
Term
| which sleep medicine has a continous release capsule, explain how it works |
|
Definition
| releases 5-10 mg immediatly and the rest over 3 h |
|
|
