Term
| The most important elimination tactic in IV drugs |
|
Definition
|
|
Term
| How does Thiopental enter the brain |
|
Definition
GABA a receptor complex
increases DURATION of Cl- channel opening |
|
|
Term
|
Definition
| decr. CBF and metabolic rate for O2 and **ICP** |
|
|
Term
|
Definition
Arterial BP, vasc resist, CO= decrease
Heart rate: increases
**patients in shock**
experience large drops in BP |
|
|
Term
| Thiopental effect on respiratory system |
|
Definition
does not relax trachea: decr. mucociliary clearance
causes **hiccups** |
|
|
Term
| clinical use of thiopental |
|
Definition
| infusion during neuroanesthesia for brain protection |
|
|
Term
| what classification is midazolam |
|
Definition
|
|
Term
| How does midazolam get into the brain |
|
Definition
GABA receptors
increasing FREQUENCY of channel opeining |
|
|
Term
| What makes midazolam water soluble and lipid soluble? |
|
Definition
water soluble: imidzazole ring remaining open
lipid soluble: imidazole closes, more unionized speeding onset of action |
|
|
Term
| Effect of Midazolam on CNS |
|
Definition
EEG resembles sleep
anterograde amnesia |
|
|
Term
| Effect of Midazolam on CV system |
|
Definition
|
|
Term
| Overdose of GABA ags can be overcome by |
|
Definition
|
|
Term
| Opioids effect on amnesia |
|
Definition
| No reliable amnesia is produced |
|
|
Term
| How do opioids get into the brain |
|
Definition
|
|
Term
|
Definition
Pruritis
Chest wall rigitidy
resp depression and apnea |
|
|
Term
| what is morphine given for? |
|
Definition
post op pain relief
analgesic supplement |
|
|
Term
| what is meperidine given for? |
|
Definition
|
|
Term
| This IV anesthetic is due to elimination |
|
Definition
| Remifentanil- the shortest acting narcotic |
|
|
Term
|
Definition
| phencyclidine derviative that produces dissociative anesthesia w/NO MUSCLE RELAXATION |
|
|
Term
|
Definition
|
|
Term
|
Definition
excitatory and hallucinatory phenomena
increases in ICP |
|
|
Term
|
Definition
| can cause hypertension and tachycardia in healthy patients |
|
|
Term
| Ketamine effect on respiratory |
|
Definition
| a very potent bronchodilator (asthma) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| *good for pts w/ICP increase* |
|
|
Term
| Etomidate effect on Cv systemn |
|
Definition
| NONE: the best agent for pts. w/compromised heart problems |
|
|
Term
|
Definition
| enhance Cl- conductance at glycine channel |
|
|
Term
| This drug has been reported to elevate mood the day after |
|
Definition
|
|
Term
| This drug has alpha 2 agonist activity |
|
Definition
|
|
