Term
| Quinilones are mainly active against gram __ bacteria |
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Definition
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Term
| ____ is the first member of the quinolone group |
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Definition
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Term
| Quinolones act by ihibiting ______ |
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Definition
| DNA gyrase (topoisomease II) |
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Term
| An important ADE of the quinolone nalidixic acid is___ |
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Definition
| Hemolysis in G-6-P deficiency |
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Term
| Which of the nucleic acid synthesis inhibitos shows hemolysis in G6P Deficiency? |
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Definition
| Nalidixic acid (Quinolone) |
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Term
| Fluroquinolones end in the suffix ____ |
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Definition
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Term
| What are the important effects of Fluorquinolones? |
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Definition
| Bactericidal, Concentration dependent bacterial killing, Postantibiotic effect |
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Term
| What is the mechanism of fluoroquinolones? |
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Definition
| Inhibit bacterial DNA gyrase |
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Term
| How do fluoroquinolones destribut to tissues like bone, prostate, and phagocytes? |
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Definition
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Term
| What is the drug of choice for treating anthrax |
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Definition
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Term
| Norfloxacin is approved only to treat? |
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Definition
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Term
| Which drug is used as prophylaxis against Pseudomonas in children with cytic fibrosis? |
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Definition
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Term
| The new FQs Levo/Gemi/Moxifloxacin are used to treat mainly_____ infections and have improved actvity against gram ___ bacteria |
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Definition
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Term
| ____ is the FQ thatis active against most betalactam and aminoglycoside resistant organisms |
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Definition
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Term
| Is Ciprofloxacin Bacteriostatic or Bactericidal? |
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Definition
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Term
| Name 5 antibiotics which can be used to treat TYPHOID fever |
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Definition
| Ciproflxacin, Levofloxacin, Ceftriaxone, Azithromycin, sulfamethoxazole-trimethoprim |
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Term
Which Nucleic acid synthsis inhibitors can present withthe following ADEs?
GI ditress rashes, CNS, Cartilage Damage, Tendonitis, QTc prolongation and Phototoxicity |
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Definition
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Term
| Along with the Fluoroquinolones _____ can also cause phootoxicity |
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Definition
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Term
| _____ enhance the CNS toxicity of Fluoroquinolones |
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Definition
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Term
| All sulfonamides are synthetic analogs of ____. |
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Definition
| PABA (paraaminobenzoic acid) |
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Term
| Sulfonamides inhibit the formation of ____ by the enzyme dihydropteroat synthase |
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Definition
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Term
| Trimehoprim inhibits the formatn of _____ by the enzyme dihydrofolate reductase |
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Definition
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Term
| In the plasma sulfonamides are ____ they are metabolized by ____ in the liver. They are widely distributed in the body including the ___. |
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Definition
| protein bound, acetylation, CSF |
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Term
| Cotrimazole or ___ is the combination of ___ & ____. |
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Definition
| Bactrim, Trimethopim, Sulfamethoxazole |
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Term
| The sulfonamide ___ is typically used topically |
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Definition
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Term
| The sulfonamide ____ is used in ulcerative colitis and rheumatoid arthritis |
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Definition
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