Term
| cholinesterase inhib used to treat AD |
|
Definition
| donepizil, galantamine, rivastigmine |
|
|
Term
| what are Ach inhibs contra'd in |
|
Definition
| asthma, COPD, gastric ulcers |
|
|
Term
| this is a centrally acting reversible achesterase inhib |
|
Definition
|
|
Term
| central acting reversible and competitive cholinesterase inhib |
|
Definition
|
|
Term
| what decreases galantamine clearance |
|
Definition
| fluoxetine and amitryptyline. |
|
|
Term
| what increases galantamine clearance |
|
Definition
|
|
Term
| this ach esterase is given as a transdermal patch |
|
Definition
|
|
Term
| side effects of rivastigmine |
|
Definition
| anorexia, dyspepsia, vomiting and diarrhea |
|
|
Term
|
Definition
| memantine at high concentrations |
|
|
Term
| what does alpha secretase cleave |
|
Definition
|
|
Term
| where does Beta secretase cleave APP |
|
Definition
|
|
Term
| where does gamma secretase cleave |
|
Definition
|
|
Term
| AB is formed by the action of what |
|
Definition
| beta and gamma secretases |
|
|
Term
| This isoform of AB has greater propensity to form aggregates |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| adverse effects of gamma secretase inhib |
|
Definition
| hematological and GI toxicity, changes in hair color |
|
|
Term
| this drug prevents tau hyperphosphorylation |
|
Definition
|
|
Term
| this is polyphenol found in red wine that reduces AB |
|
Definition
|
|
Term
| this is a fusion protein of TNF and Fc of immunoglobulin |
|
Definition
|
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