Term
| delusions, halucinations, disorganized speech, bizarre behaviors |
|
Definition
|
|
Term
| neurovegative - flat affect, poor eye contac, and lack of goal-directed activity |
|
Definition
|
|
Term
| Most patient exhibit postive/negative symptoms? |
|
Definition
|
|
Term
| MOA: older neuroleptic drugs are |
|
Definition
competitive blockers of dopamine receptors (D2)
(TYPICAL) |
|
|
Term
| MOA: newer agents are blockers of |
|
Definition
serotonin receptors (5HT2)
(ATYPICAL) |
|
|
Term
| Also block muscarinic, alpha adrenergic, and histamine receptors to varying degrees |
|
Definition
|
|
Term
| All have equivalent therapeutic efficacies |
|
Definition
| atypical and typical antipsychotics |
|
|
Term
|
Definition
|
|
Term
| low potency first generation antipsychotic agents |
|
Definition
chlorpromazine
prochlorperizine
thioridazine |
|
|
Term
| first generation antipsychotic agent (high potency) |
|
Definition
fluphenzaine
haldol
thiothixine |
|
|
Term
| second generation antipsychotic "atypical" |
|
Definition
clozapine
olanzapine
resperdal |
|
|
Term
| All reduce "positive" symptoms hallucinations and agitation by blocking dopamine receptors |
|
Definition
|
|
Term
| First generation antipsychotics are most effective against which symptoms |
|
Definition
|
|
Term
| Newer (atypical) antipsychotics are most effective against which symptoms |
|
Definition
|
|
Term
| Helps minimize the risk of EPS w/ first generation |
|
Definition
|
|
Term
due to blockage of D2 in the CTZ of the medulla
second generation less effective |
|
Definition
|
|
Term
| used to handle agitated and disruptive behavior |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Adverse effects of dopamine blockade |
|
Definition
akathisia
EPS
tardive dyskinesia
gynecomastia, amenorrhea, and galactorrhea |
|
|
Term
| 80% show adverse effects but TI is high |
|
Definition
|
|
Term
|
Definition
|
|
Term
| irreversible oral facial dyskinesia |
|
Definition
|
|
Term
| prolactin increase (D2) with all D2 antagonists |
|
Definition
gynecomastic, amonrrhea, galactorrhea
typical >> atypical |
|
|
Term
|
Definition
may cause drowiness
avoid in ETOH and other depressants
do not give to pts with glaucoma or BPH
caution in CV or hepatic disease
safety in pregnancy NOT established |
|
|
Term
| can cause acute agitation w/ alcohol may be aggravated with neuroleptics --> |
|
Definition
|
|
Term
Antipschotic, control manifestations of mania, intractable hiccups
(not used much anymore due to AE) |
|
Definition
|
|
Term
| highest occurance of sedation because of antimuscarinic and antihistaminic adverse effects |
|
Definition
|
|
Term
antipsychotic good in patients refusing oral medications because it comes in depot injection
|
|
Definition
|
|
Term
|
Definition
|
|
Term
common EPS due to low anticholinergic action
used for acute agitation
available as PO, IM, decanoate |
|
Definition
|
|
Term
antipsychotic, control manifestations of mania, control of agitation
rapid acting for highly agitated patients |
|
Definition
|
|
Term
| causes less drowsiness than the rest of the antipsychotics because less antimuscarinic, antihistaminic effects |
|
Definition
|
|
Term
low risk for EPS or tardive dyskinesia
(becaue lower effectiveness of blocking D2 receptors) |
|
Definition
|
|
Term
high risk for agranulocytosis
(loss of WBC)
reserve for refractory patients |
|
Definition
|
|
Term
| antipsychotic with less toxicity than haldol |
|
Definition
|
|
Term
no agranulocytosis risk
1st line therapy |
|
Definition
|
|
Term
| Paliperidone (Invega) - major metabolite |
|
Definition
|
|
Term
AE orthostatic hypotention & reflex tachy @ start of tx
fewer problems with EPS and TD |
|
Definition
|
|
Term
| weight gain is a major problem |
|
Definition
|
|
Term
|
Definition
|
|
Term
no weight gain
QT prolongation?
available as both oral and injectable |
|
Definition
|
|
Term
| low risk for EPS or TD w/ no agranulocytosis risk |
|
Definition
olanzapine
seroquel
geodon |
|
|
Term
| Warning on ALL atypical antipsychotics that they may induce... |
|
Definition
| hyperglycemia and diabetes type 2 (insulin insensitivity) |
|
|
Term
|
Definition
|
|
Term
often used for treatment of nausea and vomiting
(phenothiazine) |
|
Definition
prochlorperazine
promethazine
droperidol
tigan |
|
|
Term
| these can cause EPS and other adverse effects |
|
Definition
|
|
