Term
| Which anti-biotic derived chemo med is used to treat AML, ALL, CML and neuroblastoma? |
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Definition
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Term
| Which med is used to treat hematologic malignancies as well as AIDs related Kaposi's sarcoma? |
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Definition
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Term
| Which chemo meds cause cardiac toxicity b/c of its production of oxygen radicals that is dose dependent? What med can you give that decreases free-radical formation? |
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Definition
Anthracyclines (-rubicin)
Dexrazoxane |
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Term
| What is the SE of Dactinomycin (used in the tx of a Wilm's tumor)? |
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Definition
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Term
| Which med that inhibits DNA synthesis by causing the formation of oxygen radicals is used in the treatment of testicular tumors and SCC? |
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Definition
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Term
| What SE is RARE with Bleomycin? What severe SE is more common with Bleomycin? |
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Definition
| Myelosuppression; Pulmonary Fibrosis |
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Term
| What med that acts as an alkylating agent and cross-links DNA causing decreased DNA and RNA synthesis that can be used to treat solid and hematologic malignancies and can also be used as an Immunosuppression agent used to tx RA? |
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Definition
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Term
| What are the major SE of Cyclophosphamide? |
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Definition
| Hemorrhagic cystitis and Bone marrow suppression |
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Term
| Which med is used in brain tumors b/c it can cross the BBB and works by inhibiting DNA synthesis? |
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Definition
| Nitrosoureas (-mustines = Carmustine, Lomustine, Semustine and Streptozocin) |
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Term
| What drug is used in the treatment of GU tumors (testicular, ovarian and bladder) as it acts as an alkylating agent inhibiting DNA and RNA synthesis? |
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Definition
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Term
| Which chemo med that is an alkylating agent that inhibits DNA or RNA synthesis causes nephrotoxicity and ototoxicity? |
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Definition
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Term
| What med can be used in combo with a prostaglandin can be used to treat missed abortions or small ectopic pregnancies? |
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Definition
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Term
| Which med is given in conjunction with Methotrexate to reduce the SE of Bone marrow suppression? |
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Definition
| Leucovorin (folinic acid) |
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Term
| Which med is specific to the tx of ALL? |
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Definition
| 6-MP (6-Mercaptopurine) or Azathioprine |
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Term
| Which med's dosage should be lowered when used concurrently with allopurinol? |
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Definition
| 6-MP (6-Mercaptopurine) or Azathioprine |
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Term
| Which chemo med can be used in the treatment of adenocarcinomas (esp in the colon), and BCC? |
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Definition
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Term
| Which chemo agent that competitively inhibits DNA polymerase and is used to treat AML? |
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Definition
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Term
| What is the major SE of Cystarabine? |
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Definition
| Bone marrow suppression with resulting pancytopenia |
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Term
| Which chemo drug is specific to small cell lung carcinoma and works by inhibiting topoisomerase? |
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Definition
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Term
| Which med is used in the treatment of Hodkins lymphoma and ALL that works by binding to tubulin and leads to the depolarization of the mitotic spindle? |
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Definition
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Term
| Which med is used in the treatment of testicular CA and various lymphomas that works by binding to tubulin and leads to the depolarization of the mitotic spindle? |
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Definition
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Term
| Which med causes peripheral neuropathy, but is less likely to cause bone marrow suppression? |
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Definition
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Term
| Which med is used in the treatment of Ovarian and Breast CA (especially after combo therapy has failed)? |
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Definition
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Term
| Which med is used to coat coronary artery stents so as to prevent restenosis of the artery at the site of the stent? |
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Definition
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Term
| What med can be used to treat estrogen receptor positive breast CA? |
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Definition
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Term
| What estrogen-receptor modulator med can be used clinically to treat osteoporosis and to reduce the risk of invasive breast CA in post-menopausal women? |
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Definition
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Term
| What competitive estrogen-receptor antagonist increases the risk of endometrial CA, thromboembolism and gives hot flashes? |
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Definition
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Term
| Which mixed estrogen agonist/antagonist cause an increased risk of thromboembolism, but does NOT increase the pts risk for endometrial CA? |
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Definition
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Term
| Which agent that can be used in the treatment of CML works by inhibiting ribonucleotide reductase? |
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Definition
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Term
| Which chemo agent can be used to treat Sickle Cell anemia? |
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Definition
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Term
| Which med that works by inhibiting adenosine deaminase is used to treat hairy cell leukemia? |
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Definition
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Term
| Which monoclonal antibody is used in the treatment of breast CA? What receptor does it target? |
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Definition
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Term
| Which med is a competitive inhibitor of tyrosine kinase enzymes in abl, that is used to treat CML and GISTs? |
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Definition
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