Term
| 2 drugs acting on different receptors producing opposing effects is called what? |
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Definition
| physiological or funtional antagonism |
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Term
| one drug interacts directly with another opposing its effects is called what? |
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Definition
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Term
| equilibrium competitive antagonism |
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Definition
| agonist and antagonist compete for receptor and replace each other. antagonism is surmountable. Kd is effected (increased) but the efficacy is the same. |
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Term
| Non-equilibrium competitive |
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Definition
| antagonist binds covalently to the receptor effectively eliminating the number of receptors. efficacy is decreased but Kd does not change. |
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Term
| Non-competitive antagonsim |
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Definition
| antagonist binds to a different site than that of agonist. decreased efficacy, but Kd does not change. |
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Term
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Definition
| usual effects obtained at unexpectedly low dosage |
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Term
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Definition
| increased receptor sensitivity through denervation. i.e. number of receptors increase when a nerev is cut |
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Term
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Definition
| Normal effect seen only at unusually high drug dosages. Equivalent to hypoactivity but this term has the connotation of hypoactivity acquired aas a result of prior exposure to the drug. |
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Term
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Definition
| tolerance which develops rapidly after only a few drug doses |
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Term
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Definition
| unusual drug effects. may have variable intensity. are often independent of the dose and usually occurs is a small percentage of the population. |
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Term
| what is the term that defines the amount of drug required to bind to half of the receptors? |
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Definition
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Term
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Definition
| the concentration or dose that produces 50% of the maximum possible response. often used in graded D-R curves |
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Term
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Definition
| the dose that provides effect/response in 50% of individuals. often found in Quantal D-R curves |
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Term
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Definition
| concentration needed to reduce the binding of the labeled ligand by 50%. the lower the IC50 the higher the affinity |
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Term
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Definition
| when the agonist regulaets its own receptor |
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Term
| Heterospecific regulation |
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Definition
| when an agonist binds to a recpetor and regulates the synthesis of another receptor |
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