Term
|
Definition
| Tyrosine kinase inhibitor |
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Term
| Caffeine and theophylline |
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Definition
| Inhibit PDE, thus increasing action of Gs |
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Term
|
Definition
| Rapid tolerance; tyramine and amphetamine |
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Term
| Botulinum toxin action and cure |
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Definition
| Prevents release of Ach; give gastric lavage, emesis, or cathartic |
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Term
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Definition
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Term
| Organophosphates symptoms and antidote |
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Definition
| SLUDGE; atropine or 2-PAM |
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Term
| Strychnine action and cure |
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Definition
| antagonizes glycine, used for inhibiting nerve impulses; give IV diazepam or succinylcholine |
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Term
| Methanol poisoning antidote |
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Definition
| emesis, lavage, or fomepizole |
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Term
|
Definition
| Used to discourage alcohol use by inhibiting aldehyde dehydrogenase |
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Term
| Arsenic poisoning treatment |
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Definition
| Lavage and dimercaprol or penicillamine to chelate |
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Term
|
Definition
| Wrist or ankle drop; basophilic RBC stippling; lead line on gums |
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Term
|
Definition
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Term
|
Definition
| Chronic exposure causes hallucinations, delusions, jerky movements |
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Term
|
Definition
| Chelates As, Pb, Au and Hg |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| Chocolate-colored blood, causes methemaglobin formation; treat with methylene blue |
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Term
|
Definition
| Almond scent; inhibits oxygen use by mitochondria; form methemaglobin with sodium nitrite; also give sodium thiosulfate to induce rhodanese enzyme to clear |
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Term
|
Definition
| Increased risk of lung cancer |
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Term
| Ingested mineral acid, strong base, mineral spirits, convulsing action |
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Definition
| NO gastric lavage, NO emesis |
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Term
| Ingested salicylates or barbituates action |
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Definition
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Term
|
Definition
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Term
|
Definition
| Inhibits reuptake of Ach into vesicles |
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Term
|
Definition
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Term
|
Definition
| Inhibits reuptake of choline into nerve terminal |
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Term
|
Definition
| Inhibits reuptake of dopamine into vesicles |
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Term
| Cocaine, TCA, amphetamine action |
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Definition
| Inhibit reputake of NE into nerve terminal |
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Term
|
Definition
| Break down free NE for reuptake |
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Term
|
Definition
| Breakdown product of catecholamines |
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Term
|
Definition
| Breakdown product of dopamine |
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Term
|
Definition
| Inhibits tyrosine hydroxylase to prevent formation of dopamine, NE, and Epi |
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Term
|
Definition
| Inhibits release of NE from nerve terminal |
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Term
|
Definition
| Used to activate M receptors in bowel and bladder for postoperative ileus |
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Term
|
Definition
| Acts on M receptors in respiratory tract, challenge test for asthma |
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Term
|
Definition
| Acts on M receptors to increase salivation; has sweating side-effect (Cevimeline doesn't have the sweating) |
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Term
|
Definition
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Term
|
Definition
| Acts on N receptors in the brain to relieve nicotine craving |
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Term
|
Definition
| Inhibits cholinesterase; used to treat myasthenia gravis; doesn't penentrate BBB |
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Term
|
Definition
| Inhibits cholinesterase; used to diagnose myasthenia gravis |
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Term
|
Definition
| Inhibits cholinesterase to treat glaucoma; also treats atropine overdose |
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Term
|
Definition
| Cholinesterase inhibitor used to treat Alzheimer's |
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Term
|
Definition
| Cholinesterase inhibitor used to treat glaucoma |
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|
Term
| Organophosphates (sarin, DFP) |
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Definition
| Cholinesterase inhibitors that cause flaccid paralysis and death; treat with atropine or 2-PAM |
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Term
|
Definition
| Inhibits cholinesterase to treat myasthenia gravis |
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Term
|
Definition
| Muscarinic antagonist that causes mydriasis; also used to reverse bradycardia or AV block in MI |
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Term
|
Definition
| Muscarinic antagonist used to treat motion sickness; acts on CNS |
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Term
|
Definition
| Muscarinic antagonist used to cause mydriasis; also Homatropine |
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Term
|
Definition
| Muscarinic antagonist used to treat asthma; also Tiotroprium |
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Term
|
Definition
| Muscarinic antagonist used to treat overactive bladder |
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Term
| Oxybutinin and glycopyrrolate |
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Definition
| Muscarinic antagonists used to treat bladder spasm after GU surgery |
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Term
|
Definition
| Muscarinic antagonist used to treat Parkinson's disease |
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Term
|
Definition
| Muscarinic antagonist used as antispasmodic for the bowel |
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Term
|
Definition
| Nondepolarizing neuromuscular blocking agent; blocks the channel to cease effect of Ach |
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Term
|
Definition
| Depolarizing neuromuscular blocking agent; holds channel open to cause permanent depolarization of the channel |
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Term
| Rocuronium, pancuronium, vecuronium, cisatracurium, etc... |
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Definition
| Nondepolarizing neuromuscular blocking agents; reversed by cholinesterase inhibitors (neostigmine, edrophonium) |
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Term
|
Definition
| Ganglion blocker that decreases prevailing tone on all organ systems |
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Term
|
Definition
| Sympathomimetic that acts on all a and B receptors; used for anaphylaxis and hypotension; low doses increase HR; high doses pressor effect decreases HR |
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Term
|
Definition
| Similar to Epi but less pronounced effects; unsafe herbal remedy |
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Term
|
Definition
| Sympathomimetic except on B2 receptors, therefore won't cause vasodilation |
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Term
|
Definition
| a1 agonist; used for nasal decongestion |
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Term
|
Definition
| a1 agonist for hypotension IV |
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Term
|
Definition
| a1 agonist to treat postural hypotension |
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|
Term
| Xylometazoline, Oxymetazoline |
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Definition
| a agonist used to treat red eye or as nasal spray to treat congestion |
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Term
|
Definition
| a2 agonist used to decrease BP or in craving and hot flashes |
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Term
|
Definition
| B1 and B2 agonist used for heart block |
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Term
|
Definition
| B1 agonist used in heart failure and cardiac stress tests |
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Term
| Metaproterenol, albuterol, salmeterol, terbutaline |
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Definition
| B2 agonists used for asthma and to relax the uterus in premature contractions |
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Term
|
Definition
| D1 agonist that causes vasodilation and increased renal blood flow; higher doses stimulate B1 and a1 receptors |
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Term
|
Definition
| D1 agonist used to decrease BP by vasodilation |
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Term
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Definition
| Increases release of NE at terminal; CNS stimulant |
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Term
|
Definition
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Term
|
Definition
| Increases release of catecholamines from terminals; causes migraines, found in red wine and some cheeses |
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Term
|
Definition
| Competative antagonist of a1 and a2 receptors; treats pheochromocytoma; CI in peptic ulcers |
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Term
|
Definition
| Irreversible a antagonist; used to treat pheochromocytoma |
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Term
| Prazosin, terazosin, doxazosin |
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Definition
| a1 selective antagonists; treat HTN and BPH; CI with ED drugs like Sildenafil |
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Term
|
Definition
| a1 antagonist used to treat BPH |
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Term
|
Definition
| Enemy of Clonidine; a2 selective antagonist, increases release of NE |
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Term
| Propranolol, timolol, nadolol, pindolol |
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Definition
| B antagonist to treat HTN, MI, angina, arrhythmias, CHF, migraine; CI for asthmatics |
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Term
| Acebutol, Betaxolol, Esmolol, Atenolol, Metoprolol |
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Definition
| B1 antagonists to treat HTN and migraines |
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Term
|
Definition
| B1 antagonist with short duration of action used IV |
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Term
|
Definition
| B blocker that also causes vasodilation through NO |
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|
Term
|
Definition
| B blocker used to treat glaucoma |
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|
Term
| Acetazolamide, methazolamide, brinzolamide, dorzolamide, dichlorphenamide |
|
Definition
| Carbonic anhydrase inhibitors that cause HCO3- excretion and decreased body HCO3-; used for altitude sickness, glaucoma, metabolic alkalosis |
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|
Term
| Furosemide, bumetanide, torsemide |
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Definition
| Loop diuretics that inhibit NKCC2 channel in ascending loop of Henle; Sulfa drugs |
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Term
|
Definition
| Loop diuretic that inhibits NKCC2 channel in ascending loop of Henle |
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Term
|
Definition
| Diuretic that inhibits Na resorption at DCT; Sulfa drug |
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Term
|
Definition
| Diuretic similar to thiazides |
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Term
|
Definition
| Diuretic similar to thiazides |
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|
Term
| Spironolactone, eplerenone |
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Definition
| K+ sparing diuretics that antagonize aldosterone receptors |
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Term
|
Definition
| K+ sparing diuretics that block Na+ resorption in CD |
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|
Term
| Mannitol, isosorbide, glycerin, urea |
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Definition
| Osmotic diuretics that pull water with them into CD |
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Term
| Vasopressin, desmopressin |
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Definition
| ADH agonists, used to control polyuria, dehydration in pts with central diabetes insipidus |
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Term
|
Definition
| ADH antagonist used to treat CHF and SIADH |
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Term
|
Definition
| Uncouples V2 from cAMP to induce nephrogenic diabetes insipidus |
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Term
|
Definition
| Inhibits Na/K ATPase to increase contractility of heart by increase available intracellular Na; inhibited by K, enhanced with Ca; increases SV, CO, but decreases heart rate; first signs of toxicity are GI |
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Term
|
Definition
| Inhibit cAMP PDE in heart to improve heart contractility |
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Term
|
Definition
| Synthetic BNP that increases cGMP to cause vasodilation therefore treats acute decompensated heart failure |
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Term
|
Definition
| Class IA antiarrhythmic that blocks open Na channels; used for affects atria and ventricles |
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Term
|
Definition
| Class IA antiarrhythmic that blocks open Na channels |
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Term
|
Definition
| Class IA antiarrhythmic that blocks open Na channels |
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Term
|
Definition
| Quinidine toxicity includes HA, tinnitus, purpura |
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|
Term
|
Definition
| Class IB antiarrhythmic that blocks inactivated Na channels; used in ventricular arrhythmias |
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Term
|
Definition
| Class IB antiarrhythmic that blocks closed Na channels |
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|
Term
|
Definition
| Class IB antiarrhythmic that blocks closed Na channels |
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|
Term
|
Definition
| Class IB antiarrhythmic that blocks closed Na channels |
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Term
|
Definition
| Class IC antiarrhythmic that blocks all Na channels; used in V-tachs and SVT |
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|
Term
|
Definition
| Class IC antiarrhythmic that blocks all Na channels |
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|
Term
|
Definition
| Class IC antiarrhythmic that blocks all Na channels |
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|
Term
|
Definition
| Class III antiarrhythmic that blocks K channels; used for atrial and ventricular arrhythmias |
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|
Term
|
Definition
| Class III antiarrhythmic that blocks K channels |
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|
Term
|
Definition
| Class III antiarrhythmic that blocks K channels |
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|
Term
|
Definition
| Class III antiarrhythmic that blocks K channels |
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|
Term
|
Definition
| Class III antiarrhythmic that blocks K channels |
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|
Term
|
Definition
| Class IV antiarrhythmic that blocks Ca channels; use for SVT; no vasodilatory properties |
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Term
|
Definition
| Class IV antiarrhythmic that blocks Ca channels; also has vasodilatory properties |
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Term
|
Definition
| Antiarrhythmic drug that is DOC for SVT and Wolf-Parkinson-White; enhances K conductance to hyperpolarize the cell; STOPS THE HEART |
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Term
|
Definition
| Used as an antiarrhythmic for torsade de pointes |
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Term
|
Definition
| Vasodilator that increases cGMP to cause arteriole>venule vasodilation; used to treat HTN |
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|
Term
|
Definition
| Vasodilator that acts by NO to increase cGMP to cause vein>arteries to dilate |
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|
Term
|
Definition
| Directly releases NO to increase cGMP to cause vasodilation in malignant HTN |
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|
Term
|
Definition
| Opens K channels to cause vasodilation in arterioles > veins |
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|
Term
|
Definition
| Opens K channels to cause vasodilation; used for malignant HTN; can cause hyperglycemia |
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|
Term
| Dihydropyridines "-dipines" |
|
Definition
| Ca channel blockers that cause vasodilation; no effects on heart; treat Prinzmetal angina |
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Term
|
Definition
| Inhibit ACE; used to treat HTN; side effects are cough, angioedema |
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|
Term
|
Definition
| Angiotensin II receptor blockers for HTN but do not increase kallikrien so NO COUGH |
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|
Term
|
Definition
| Na channel blocker used to treat angina |
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|
Term
|
Definition
| Endothelin receptor antagonist that causes vasodilation, used to treat angina |
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|
Term
|
Definition
| Releases NO to cause vasodilation of veins > arteries for treatment of angina |
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|
Term
|
Definition
| Inhibits lipolysis in adipose tissue to decrease VLDL and increase HDL |
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|
Term
| Gemfibrozil, Clofibrate, Fenofibrate |
|
Definition
| Fibric acid derivatives that upregulate LPL to clear VLDL from circulation |
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|
Term
| Colestipol, cholestyramine, colesevelam |
|
Definition
| Bile acid binding resins that are ingested to prevent bile acids resorption |
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Term
|
Definition
| HMG-CoA reductase inhibitors that inhibit cholesterol precursor to decrease cholesterol production; increase LDL receptor, decrease triglycerides, increase HDL, decrease CRP, increase NO, increase plaque stability, decrease platelet aggregation |
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Term
|
Definition
| Cholesterol absorption blocker |
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Term
|
Definition
| Catalyst for antithrombin III causing breakdown of Xa and thrombin, decreasing clotting; measured by PTT, inactivated by protamine sulfate; toxicity is Heparin induced Thrombocytopenia |
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|
Term
| Enoxaprin, daltaparin, danaparoid |
|
Definition
| LMW heparins that are used as anticoagulants if HIT with heparin |
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Term
|
Definition
| Pentasaccharide that is used as an anticoagulant if HIT with heparin |
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Term
|
Definition
| Thrombin inhibitor, anticoagulant |
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Term
|
Definition
| Thrombin inhibitors, anticoagulants |
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Term
|
Definition
| Direct inhibitor of factor X, oral; anticoagulant |
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Term
|
Definition
| Inhibits reducing of Vitamin K, synthesis of factors VII, II, IX, X; oral; measured by INR and tested with PT; reverse with Vitamin K |
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Term
|
Definition
| Give to counteract effects of heparin |
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Term
|
Definition
| Give to counteract the effects of warfarin |
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Term
|
Definition
| Thrombolytic; activates formation of plasmin from plasminogen, which degrades fibrin and fibrinogen |
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|
Term
|
Definition
| Thrombolytic; activates formation of plasmin from plasminogen, which degrades fibrin and fibrinogen |
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|
Term
|
Definition
| Thrombolytic; activates formation of plasmin from plasminogen, which degrades fibrin and fibrinogen |
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|
Term
| Aminocaproic acid, transexamic acid |
|
Definition
| Antifibrinolytics; inhibit action of thrombolytics to keep clots around, prevents formation of plasmin from plasminogen |
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Term
|
Definition
| Antiplatelet; inhibits formation of COX to prevent formation of TXA2, increases bleeding time |
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|
Term
| Clopidogrel, ticlopidine, prasugrel |
|
Definition
| Antiplatelet; blocks ADP receptor on platelets |
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|
Term
| Abiciximab, eptifibatide, tirofiban |
|
Definition
| Antiplatelet; inhibit GPIIb/IIIa from binding to fibrinogen |
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|
Term
|
Definition
| PDE3 inhibitor, increases cAMP levels; used in intermittent claudication |
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