Term
|
Definition
|
|
Term
| B-blockers: pharm effects |
|
Definition
| reduced HR, contractility, BP (decrease cardiac work and myocardial O2 demand); decreased HR (longer coronary perfusion time, increases supply) |
|
|
Term
| B-blockers: adverse effects |
|
Definition
| increased end diastolic ventricular volume (preload), increased ejection time (both increase myocardial work and O2 demand); bronchoconstriction, vasoconstriction, hypoglycemia |
|
|
Term
|
Definition
| angina pectoris, arrhythmias, HTN, MI |
|
|
Term
|
Definition
|
|
Term
|
Definition
| inhibition of PDE 5 increases cGMP concentration (decreases cGMP dephosphorylation to GMP), vasodilation of corpora cavernosa smooth muscle-->erection. Requires an intact parasympathetic function for the production of NO |
|
|
Term
| Sildenafil: adverse effects |
|
Definition
| potentiates the action of organic nitrates-->hypotension and MI |
|
|
Term
|
Definition
| guanylyl cylcase via enzymatic generation of NO |
|
|
Term
|
Definition
| large 1st pass: give sub-lingual, patch or LARGE oral dose |
|
|
Term
| Organic nitrates: pharm effects |
|
Definition
| cGMP enhances vascular smooth muscle relaxation-->venodilation reduces preload |
|
|
Term
|
Definition
|
|
Term
| Organic nitrates: adverse effects |
|
Definition
| postural hypotension, reflex sympathetic stimulation (palpitations), dilation of meningeal vessels (headache), interaction with sildenafil, tolerance (Monday disease) |
|
|
Term
| Calcium Channel Blockers: tissues containing L-type Ca channels |
|
Definition
| cardiac and smooth muscle |
|
|
Term
| Calcium Channel Blockers: pharm effects |
|
Definition
| decreased smooth muscle tone (BP), contractility, HR, SA and AV node conduction |
|
|
Term
| Calcium Channel Blockers: uses |
|
Definition
|
|
Term
| Calcium Channel Blockers: types |
|
Definition
| Nifedipine (vascular>cardiac), verapamil and diltiazem (vascular = cardiac) |
|
|
Term
| Calcium Channel Blockers: target |
|
Definition
|
|
Term
| Calcium Channel Blockers: adverse effects |
|
Definition
| hypotension, refelx tachycardia (N), headache, myocardial depression (V/D), CHF, bradycardia, AV block, constipation |
|
|
Term
| Beneficial combinations for angina |
|
Definition
| Nitrate + B-blocker (or verapamil), nifedipine + B-blocker (or verapamil) |
|
|
Term
| Adverse drug combos for angina |
|
Definition
| nifedipine + nitrate (hypotension and MI); verapamil + b-blocker (depresses myocardium too much) |
|
|
