Term
| What is acyclovir given for? How does resistance happen? How does it work? |
|
Definition
| HSV and VSV, activated to acyclovir triphosphate by thymidine kinase in virus, guanosine analogue is incorporated into viral DNA, chain termination, mutation in viral DNA- poly, TK- strains are resistant |
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Term
|
Definition
| delirium, tremor, seizures, hypotension, nephrotox |
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Term
| Famciclovir is converted to... |
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Definition
|
|
Term
| What is famciclovir given for? Is it phosphorylated? Does it terminate the chain? |
|
Definition
| genital HSV and zoster, yes, NO |
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Term
| valacyclovir is converted to... |
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Definition
|
|
Term
| what is the benefit of valacyclovir? |
|
Definition
| increased plasma levels, longer DOA |
|
|
Term
| Is foscarnet phosphorylated? What does it do? |
|
Definition
| no, inh viral RNA poly, DNA poly, HIV RTase |
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Term
|
Definition
| nephrotox, decreased Ca, GU ulcers, CNS effects |
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Term
| Does ganciclovir need phosphorylation? What does it do? Does it terminate the chain? |
|
Definition
| yes, inh DNA poly of HSV, and CMV, and other, NO |
|
|
Term
| Is TK- HSV resistant to ganciclovir? |
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Definition
|
|
Term
| How are foscarnet and ganciclovir given? What is gancicovir given for? |
|
Definition
|
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Term
|
Definition
| leukopenia, thrombocytopenia, mucositis, hepatic dysfunction, seizure -- like radiation therapy side effects |
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|
Term
| What phosphorylates cidofovir? What does it do? |
|
Definition
| HOST kinases, inh DNA poly of HSV, CMV, adeno, papillomaviruses |
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Term
|
Definition
| IV, topical, intravitreal |
|
|
Term
| For most of the anti-herpes drugs, renal elimination is equal to... |
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Definition
|
|
Term
| What is cidofovir given for? Tox? |
|
Definition
| CMV retinitis, HSV, HPV, tox- nephro |
|
|
Term
| Which anti-herpes drug can have up to 1/3 deposited in bone? |
|
Definition
|
|
Term
| Penciclovir is used in which form? |
|
Definition
|
|
Term
| What is valganciclovir used for? |
|
Definition
| CMV retinitis and prophylaxis |
|
|
Term
| How is trifluridine used? For what? |
|
Definition
| Topically, for herpes keratitis and acyclovir-resistant HSV |
|
|
Term
| What class of drugs are these? - Abacavir, didanosine (ddI), emtricitabine, lamivudine, stavudine, tenofovir, zalcitabine, zidovudine |
|
Definition
| NRTI - nucleoside reverse transcriptase inhibitors |
|
|
Term
| all NRTIs carry the risk of... |
|
Definition
| lactic acidosis with hepatic steatosis |
|
|
Term
|
Definition
| BM suppression, anemia, neutropenia, GI, HA, thrombocytopenia, myalgia, cholestatic hepatitis, insomnia |
|
|
Term
| What should you do before giving abacavir? |
|
Definition
| test to rule out HLA B*5701 |
|
|
Term
| What impairs the absorption of ddI (didanosin)? What else should you avoid at the same time? |
|
Definition
| food, fluoroquinolones and tetracyclines |
|
|
Term
| didanosine (ddI), zalcitabine and stavudine are ____ drugs that can cause _______ |
|
Definition
| NRTI, peripheral neuropathy |
|
|
Term
| didanosine and zalcitibine are ____ drugs than can cause... |
|
Definition
|
|
Term
| Which NRTIs can cause pancreatitis? |
|
Definition
|
|
Term
| Which NRTIs can cause peripheral neuropathy? |
|
Definition
| ddI, stavudine, zalcitabine |
|
|
Term
|
Definition
| hypersensitivity, can cause multiorgan failure |
|
|
Term
| If you're taking ddI , you should avoid... |
|
Definition
|
|
Term
|
Definition
| mild, GI, HA, insomnia, fatigue |
|
|
Term
| What class of drug are these: Delavirdine, efavirenz, etravirine, nevirapine |
|
Definition
| non-nucleoside reverse transcriptase inhibitors- NNRTIs |
|
|
Term
| Are NNRTI drugs phosphorylated? |
|
Definition
| no, and they bind the RT at a different site |
|
|
Term
| Which NNRTI can raise cholestrol, cause CNS dysfunction, and a rash? |
|
Definition
|
|
Term
|
Definition
| major interactions due to CYP metabolism, skin rash |
|
|
Term
| Which NNRTI can cause SJ syndrome? |
|
Definition
|
|
Term
| Which NNRTI can cause occasionally fulminant hepatitis? |
|
Definition
|
|
Term
| What type of drug is enfuvirtide? |
|
Definition
|
|
Term
| Drugs that end with "-avir" are generally what types of drugs? What are the exceptions? |
|
Definition
| protease inhibitors, abacavir, reltegravir, and tenfovir |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Which protease inhibitor can prolong the PT and/or QT intervals? |
|
Definition
|
|
Term
| Best to take indinavir with food? |
|
Definition
|
|
Term
| Protease inhibitors have effects on... |
|
Definition
| carbohydrate and lipid metabolism |
|
|
Term
| Which drug is used in HBV? |
|
Definition
|
|
Term
| Which drug inhibits GTP formation, capping of viral mRNA and RNA polymerase? |
|
Definition
|
|
Term
| Which drugs work on influenza A by affecting viral adsorption, penetration and uncoating? Tox? |
|
Definition
| amantadine and rimantadine, tox - ataxia, dizziness, slurring, GI |
|
|
Term
| Which are the neuroaminidase inhibitors? |
|
Definition
| oseltamavir and zanamavir |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| condensed version: side effects of ganciclovir? |
|
Definition
| neutro,thrombo and leukocytopenia |
|
|
Term
| Anti-viral agents associated with SJ syndrome? |
|
Definition
|
|
Term
| Which class of HIV drugs have extensive drug interactions due to inhibition of metabolizing enzymes? |
|
Definition
|
|
Term
| Anti-virals that are teratogens? |
|
Definition
| Delavirdine, efavirenz, and ribavirin |
|
|
Term
| Anti-virals associated with neutropenia? |
|
Definition
| ganciclovir, zidovudine, saquinavir and IFN |
|
|
Term
| Which HIV med is used to reduce transmission to baby during birth? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Anti-viral with a dose-limiting toxicity of pancreatitis? |
|
Definition
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