Term
| Levothyroxine and liothyronine: MOA? Max effect seen after how long? Tox? |
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Definition
| activation of nuclear receptors, gene expression with RNA formation and protein synthesis. 6-8 wks. Symptoms of thyroid excess. |
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Term
| What is propylthiouracil? What is the MOA? Duration of action? Onset? Tox? |
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Definition
| a thioamide, inhibits thyroid peroxidase reactions, blocks, iodine organification, inhibits peripheral conversion of T4 and T3. DOA 6-8 hrs, delayed onset. Nausea, GI distress, rash, agranulocytosis, hepatitis, hypothyroidism. |
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Term
| What are lugol solution and potassium iodide? MOA? Indications? |
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Definition
| iodides, inhibit organification and hormone release, reduce size and vascularity of the gland. Preparation for thyroidectomy |
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Term
| What does propanolol do? Indications? Toxicity? |
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Definition
| Inhibits beta receptors, inhibits T4-T3 conversion in large doses. Hyperthyroidism esp thyroid storm, adjunct to control tachycardia, hypertension and A-fib. Asthma, AV blockade, hypotension, bradycardia |
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Term
| How does radioactive iodine (131) work? Indications? Who should avoid it? Max effect in how long? Tox? |
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Definition
| destroys thyroid parenchyma. Hyperthyroidism, pts should be euthyroid or on B-blockers first, avoid in pregnancy or in nursing moms. 3-6 mo. Sore throat, sialitis, hypothyroidism |
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