Term
|
Definition
| Gonadorelin, Goserelin, Histrelin, Leuprolide, Nafarelin |
|
|
Term
|
Definition
|
|
Term
| Testosterone to DHT Conversion Inhibitors |
|
Definition
|
|
Term
|
Definition
| Inhibit type II 5alpha-reductase |
|
|
Term
|
Definition
| Benign prostatic hyperplasia, Androgenic alopecia {Male breast neoplasm, breast tenderness, decreased libido, ED, ejaculatory disorder} [Pregnancy, women/children] Improves decreased urine flow. TURP alternative. Effective prostate reduction. Women should not handle |
|
|
Term
|
Definition
| Anastrozole, Letrozole, Exemestane, Formestane |
|
|
Term
| Competitive/Reversible Aromatase Inhibitors |
|
Definition
|
|
Term
| Irreversible/Suicide Aromatase Inhibitors |
|
Definition
|
|
Term
| Anastrozole, Letrozole, Exemestane, Formestane |
|
Definition
| Early-stage and metastatic estrogen receptor positive breast cancer {Osteoporotic fracture, thrombophlebitis, hypercholesterolemia, vaginal bleeding, edema, rash, nausea, arthralgia, bone pain, headache, depression dyspnea} [hypersensitivity] May be more effective than estrogen antagonists or SERMS |
|
|
Term
| Selective Estrogen Receptor Modulators (SERMS) |
|
Definition
| Tamoxifen, Clomiphene, Raloxifene |
|
|
Term
|
Definition
| Prevention/Palliative for breast cancers, post-lumpectomy {Malignant neoplasm of endometrium, stroke, cataract, pulmonary embolism, hot flashes, abnormal menses, vaginal discharge} [DVT or PE history, not a concern for breast cancer] No more than 5 years due to endometrial cancer risk |
|
|
Term
|
Definition
| Female infertility due to anovulation {Thromboembolism, ovarian cysts, ovarian hypertrophy, flushing, vasomotor symptoms, abdominal discomfort} [Pregnancy, thyroid or adrenal dysfunction, liver disease, endometrial carcinoma, ovarian cysts, intracranial lesion] |
|
|
Term
|
Definition
| Estrogen receptor antagonist in hypothalamus and anterior pituitary, partial agonist in ovaries. Disinhibitis GnRH release. Increases FH and LSH. |
|
|
Term
| Estrogen Receptor Antagonists |
|
Definition
|
|
Term
|
Definition
| Treatment of ER+ metastatic breast cancer in post-menopausal women when anti-estrogen ineffective. {Nausea, asthenia, pain, vasodilation, headache} [Pregnancy] SERD |
|
|
Term
| Androgen Receptor Antagonists |
|
Definition
| Flutamide, Spironolactone |
|
|
Term
|
Definition
| Metastatic prostate cancer, Benign prostatic hypertrophy {Hepatotoxicity, hematopoietic system disorders, hot flash, diarrhea, nausea, rash} [severe hepatic impairment] Better than DES and leuprolide. Combine with castration. |
|
|
Term
|
Definition
| hirsutism, Acne vulgaris, hypertension, edema with HF or cirrhosis, hypokalemia, primary aldosteronism {Hyperkalemia metabolic acidosis, GI hemorrhage, agranulocytosis, SLe, breast cancer?, gynecomastia, dyspepsia, lethargy, abnormal menstruation, impotence, rash} [anuria, hyperkalemia, renal insufficiency] Activity at androgen receptor |
|
|
Term
| Progesterone Receptor Antagonists |
|
Definition
| Mifepristone (RU-486), Asoprisnil |
|
|
Term
|
Definition
| Abortion through day 49. {Prolonged bleeding time, bacterial infections, sepsis, nausea, vomiting diarrhea, cramps, abnormal vaginal bleeding headache} [Chornic adrenal failure, ectpic pregnancy, blooding disorders, porhyrias, IUD, adnexal mass] |
|
|
Term
|
Definition
| Progesterone block causes decay of decidua. Misoprostol coadministration stimulates uterine contractions and nausea. Potentially useful for ectopic ACTH syndrome |
|
|
Term
|
Definition
| Investigational agent for endometriosis and leiomyomata (fibroids) |
|
|
Term
|
Definition
| Ethinyl estradiol, Mestranol |
|
|
Term
|
Definition
| Norgestrel, Levonorgestrel, Norethindrone, Norethindrone acetate, Ethynodiol, Norgestrimate, Gestodene, Desogestrel, Drospirenone |
|
|
Term
| Estrogen-Progestin Contraception Adversia |
|
Definition
| {Arterial venous thromboembolism, PE, stroke, cholecystitis, HTN, hepatic neoplasm, break-through bleeding, breast tenderness, bloating, migraine, weight change} [Breast/endometrial/liver cancer, Pregnancy, smokers over 35, thrombotic disorders, HTN, immobilization, Heart/cerebral artery disease] |
|
|
Term
|
Definition
| Emergency contraception (Morning after or Plan B pill) |
|
|
Term
| Norgestrel and Levonorgestrel |
|
Definition
| highest androgenic activity |
|
|
Term
| Norethindrone and norethindrone acetate |
|
Definition
| Medium androgenic activity |
|
|
Term
| Ethynodiol, norgestimate, gestodene, and desogestrel |
|
Definition
| Low androgen receptor cross-reactivity |
|
|
Term
|
Definition
|
|
Term
| Progestin only Contraceptives |
|
Definition
| Norgestrel, Norethindrone, Medroxyprogesterone acetate, Etonogestrel |
|
|
Term
|
Definition
| Injectable every 3 months |
|
|
Term
|
Definition
| Silastic implant for 3 years |
|
|
Term
| Hormone Replacement Androgens |
|
Definition
| Testosterone enenthate, Testosterone cypionate |
|
|
Term
| Testosterone enanthate/cypionate |
|
Definition
| Hypogonadism {Cholestatic jaundice, liver carcinoma, benign prostatic hyperplasia, prostate cancer, acne, gynecomastia, irritation, transfer to female, headache} [Breast/prostate cancer, Pregnancy] Various administration routes. Abused by athletes |
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