Term
| Glucoroticoid Receptor Agonists |
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Definition
| Prednisone, predisolone, methylprednisolone, dexamethasone, hydrocotisone, fluticasone, beclomethasone, flunisolide, triamcinolone, budesonide: autoimmune disease, replacement (Immunosuppression, cataracts, hyperglycemia, osteoporisis, atrophy) [Fungal Infection] Avoid sudden withdrawal |
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Term
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Definition
| Replacement therapy for primary and secondary adrenal insufficiency |
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Term
| Glucocorticoid Receptor Antagonists |
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Definition
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Term
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Definition
| RU-486: Abortion (Prolonged bleeding time, bacterial infections, sepsis, nausea) [Chronic adrenal failure, ectopic pregnancy, porphyrias, IUD, anticoagulation] Progesterone receptor antagonist |
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Term
| Glucocorticoid Synthesis Inhibitors |
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Definition
| Mitotane, aminoglutethimide, Metyrapone, trilostane, ketoconazole |
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Term
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Definition
| Medical adrenalectomy (Cushing's) or adrenocortical carcinoma. (Visual disturbance, hemorrhagic cystitis) [Live rotavirus vaccine] analogue of DDT toxic to adrenocortical mitochondria. Hypercholesterolemia. |
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Term
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Definition
| Cushings. (Cortisol insufficiency, agranulocytosis, pruritus) inhibits side-chain cleavage enzyme as well as aromatase. |
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Term
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Definition
| Diagnosis, Cushing's. (Cortisol insufficiency, HTN) Inhibits 11beta-bydroxylation. Disinhibition of ACTH secretion. |
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Term
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Definition
| Cushings's syndrome. Aldosteronism (Addisonian crisis, postural hypotension, hypoglycemia) [renal or hepatic dysfunction] reversible 3beta-hydroxysteroid dehydrogenase inhibitor |
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Term
| Mineralocorticoid Receptor Agonists |
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Definition
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Term
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Definition
| Hypoaldosteronism. (Hypertension, hypokalemia, HF, thrombophlebitis, hypocortisolism, intracranial pressure increase, edema) [systemic fungal infection] mimics a state of mineralocorticoid excess |
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Term
| Mineralocorticoid receptor antagonists |
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Definition
| Spironolactone, eplerenone |
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Term
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Definition
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Term
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Definition
| Dehydroepiandrosterone: Hypoaldosteronism, Fatigue (Acne, hepatitis, hirsutism) [sex cancers] Addison's replacement. Commonly abused |
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