Term
| Glucocorticoid Receptor Agonists |
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Definition
| Prednisone, Predisolone, Methylprednisolone, Dexamethazone, Hydrocortisone, Fluticasone, Beclomethasone, Flunisolide, Triamcinolone, Budesonide |
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Term
| Glucocorticoid Agonist Information |
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Definition
| Inflammatory conditions, autoimmune diseases {Immunosuppression, cataracts, hyperglycemia, hypercortisolism, depression, euphoria, osteoporosis, growth retardation, muscle atrophy, poor healing, HTN, fluid retention} [fungal infection] Taper slowly off of these. Inhaled: fluticasone, beclomethasone, flunisolide, triamcinolone, budesonide |
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Term
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Definition
| Replacement therapy for adrenal insufficiency |
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Term
| Gluco/Mineral-corticoid Relative potency |
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Definition
| Hydrocortisone: 1/1; Prednisolone: 4.5/.25; Methylprednisolone: 5.5/.25; Dexamethasone: 18/0 |
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Term
| Glucocorticoid Receptor Antagonists |
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Definition
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Term
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Definition
| Abortion through day 49 {Prolonged bleeding, bacterial infection/sepsis, nausea, vomiting, diarrhea, cramps, vaginal bleeding, headache} [adrenal failure, ectopic pregnancy, henorrhagic disorders, anticoagulation, inherited porphyrias, IUD, adnexal mass] Also blocks progesterone receptor |
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Term
| Glucoorticoid Synthesis Inhibitors |
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Definition
| Mitotane, Aminoglutethimide, Metyrapone, Trilostane, Ketoconazole |
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Term
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Definition
| Medical adrenalectomy in Cushing's or adrenocortical carcinoma {Visual disturbance, hemorrhagic cystitis, hypercholesterolemia, somnolence, nausea, depression} [Live rotavirus vaccine] analogue of DDT. Hypercholesterolemia |
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Term
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Definition
| Cushing's syndrome {Cortisol insufficiency, agranulocytosis, leukopenia, neutropenia, pancytopenia, pruritus, nausea, hypotension, somnolence} [Hypersensitivity to glutethimide] Inhibits side-chain cleavage enzyme as well as aromatase. Potential for breast cancer. |
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Term
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Definition
| Diagnosis ofr hypothalamic-pituitary-adrenal axis, Cushing's {Cortisol insufficiency, HTN} [Cortical insufficiency] Inhibits 11beta-hydrozyltion, disinhibition of ACTH secretion to test reserve |
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Term
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Definition
| Cushing's syndrome, Aldosteronism {Addisonian crisis, Postural ypotension, hypoglycemia, diarrhea, nausea} [cortical insufficiency, renal/hepatic dysfunction] reversible 3beta-hydroxysteroid dehydrogenase inhibitor |
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Term
| Mineralocorticoid Receptor Agonists |
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Definition
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Term
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Definition
| Hypoaldosteronism {HTN, hypokalemia, HF, thrombophlebitis, hypocortisolism, increased intracranial pressure, edema, impaired healing, rash, mypathy, hyperglycemia, menstrual irregularities} [fungal infection] |
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Term
| Mineralocorticoid Receptor Antagonists |
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Definition
| Spironolactone, Eplerenone |
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Term
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Definition
| Dehydroepiandresterone (DHEA) |
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Term
| DHEA (Dehydroepiandrosterone) |
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Definition
| Hypoaldosteronism, Chronic fatigue syndrome {Acne, hepatitis, hirsutism, androgenization} [Breast/ovarian/prostate cancer] Replacement for addison's with DHEA deficiency. |
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