Term
|
Definition
| sedation, tolerance, dependence |
|
|
Term
| sedation, tolerance, dependence - tox of which drugs? |
|
Definition
|
|
Term
|
Definition
| diplopia, ataxia, blood dyscrasias, liver tox, teratogenesis, induction of CYP, SIADH, SJ syndrome |
|
|
Term
| tox: diplopia, ataxia, blood dyscrasias, liver tox, teratogenesis, induction of CYP, SIADH, SJ syndrome. NAME THE DRUG. |
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Definition
|
|
Term
|
Definition
| fatigue, GI, headache, urticaria, SJ syndrome |
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|
Term
| tox: fatigue, GI, headache, urticaria, SJ syndrome. NAME THE DRUG. |
|
Definition
|
|
Term
|
Definition
| sedation, tolerance, dependence, induction of CYP450 |
|
|
Term
| tox: sedation, tolerance, dependence, induction of CYP450. NAME THE DRUG. |
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Definition
|
|
Term
|
Definition
| nystagmus, diplopia, ataxia, sedation, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogenesis (fetal hydantoin syn), SLE-like syndrome, induction of CYP |
|
|
Term
| Tox: nystagmus, diplopia, ataxia, sedation, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogenesis (fetal hydantoin syn), SLE-like syndrome, induction of CYP. NAME THE DRUG. |
|
Definition
|
|
Term
|
Definition
| GI distress, rare but fatal hepatotoxicity (measure LFTs), neural tube defects, tremor, weight gain. Contraindicated in pregnancy. |
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|
Term
| Tox: GI distress, rare but fatal hepatotoxicity (measure LFTs), neural tube defects, tremor, weight gain. Contraindicated in pregnancy. NAME THE DRUG. |
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Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Tox: sedation, ataxia. NAME THE DRUG. |
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Definition
|
|
Term
|
Definition
| sedation, mental dulling, kidney stones, weight loss |
|
|
Term
| tox: sedation, mental dulling, kidney stones, weight loss. NAME THE DRUG |
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Definition
|
|
Term
| SJ syndrome - skin CELs come off. Which drugs cause it? |
|
Definition
| Carbamazepine, Ethosuximide, Lamotrigine |
|
|
Term
|
Definition
| use-dependent blockade of Na channels, ^ refract period, inh of glutamate release from excitatory presyn neuron |
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|
Term
| MOA: use-dependent blockade of Na channels, ^ refract period, inh of glutamate release from excitatory presyn neuron. NAME THE DRUG. |
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Definition
|
|
Term
| what is phenytoin used for besides seizures? |
|
Definition
| it's a class IB antiarrhythmic |
|
|
Term
| Chronic use of phenytoin produces... |
|
Definition
| gingival hyperplasia in kids, peripheral neuropathy, hirsutism, megaloblastic anemia |
|
|
Term
| Which drugs are NOT used for simple or complex partial seizures? |
|
Definition
|
|
Term
| ethosuximide, benzos have no use in... |
|
Definition
|
|
Term
| What are first-line agents for generalized tonic-clonic seizures? |
|
Definition
| Phenytoin, carbamazepine, valproic |
|
|
Term
| Phenytoin, carbamazepine, valproic - 1st line agents for... |
|
Definition
| generalized tonic-clonic seizures |
|
|
Term
| Which drugs are NOT used for generalized tonic-clonic seizures? |
|
Definition
| ethosux, benzos, tiagabine, vigabatrin |
|
|
Term
| ethosux, benzos, tiagabine, vigabatrin - NOT used for... |
|
Definition
| generalized tonic-clonic seizures |
|
|
Term
| What's the 1st line drug for absence seizures? What else can be used? |
|
Definition
|
|
Term
| Ethosux is first line and valproic is backup drug for... |
|
Definition
|
|
Term
| What's the 1st line drug for PROPHYLAXIS of status epilepticus? What's the 1st line for ACUTE TREATMENT? |
|
Definition
| phenytoin for prophylaxis, diazepam or lorazepam for acute |
|
|
Term
| What is phenytoin good for? |
|
Definition
| Partial, tonic clonic (1st), prophylaxis of status epilepticus (1st) |
|
|
Term
| ______ is good for partial, tonic clonic, prophylaxis of status epilepticus |
|
Definition
|
|
Term
| What is carbamazepine good for? |
|
Definition
| partial, tonic clonic (1st) |
|
|
Term
| ________ is good for partial, tonic clonic (1st) |
|
Definition
|
|
Term
| What is lamotrigine good for? |
|
Definition
|
|
Term
| What is topiramate good for? |
|
Definition
|
|
Term
| What is gabapentin good for? |
|
Definition
|
|
Term
| What is phenobarbital good for? |
|
Definition
|
|
Term
| What is levetiracetam good for? |
|
Definition
|
|
Term
| What are the drugs that are ONLY used in partial and tonic-clonic seizures, not as 1st line? |
|
Definition
| lamotrigine, gabapentin, topiramate, phenobarbital, levetiracetam |
|
|
Term
| lamotrigine, gabapentin, topiramate, phenobarbital, levetiracetam -- these drugs are not 1st line agents, and they are only used in... |
|
Definition
|
|
Term
| What is ethosux good for? |
|
Definition
|
|
Term
| Which drug is only good for absence? |
|
Definition
|
|
Term
| What are benzos good for? |
|
Definition
| 1st line for acute status |
|
|
Term
| Which drugs are only good for acute status (1st line)? |
|
Definition
|
|
Term
| What is tiagabine good for? |
|
Definition
|
|
Term
| what is vigabatrin good for? |
|
Definition
|
|
Term
| Which drugs are used ONLY in partial seizures? |
|
Definition
|
|
Term
| tiagabine and vigabatrin are used ONLY in... |
|
Definition
|
|
Term
| Which drugs ^ Na+ channel inactivation? |
|
Definition
| phenytoin and carbamazepine |
|
|
Term
| Which drugs work by ^ Na+ channel inactivation? |
|
Definition
|
|
Term
| What is used for parenteral phenytoin administration? |
|
Definition
|
|
Term
| Which drug is 1st line for trigeminal neuralgia? |
|
Definition
|
|
Term
|
Definition
| blocks voltage-gated Na+ channels |
|
|
Term
| Which drug blocks voltage-gated Na+ channels? |
|
Definition
|
|
Term
|
Definition
| designed as GABA analog, but primarily inhibits HVA Ca+ channels |
|
|
Term
| Which drug was designed as GABA analog, but primarily inhibits HVA Ca+ channels? |
|
Definition
|
|
Term
| Which drug is also used for peripheral neuropathy and bipolar disorder? |
|
Definition
|
|
Term
| gabapentin is also used for... |
|
Definition
| peripheral neuropathy and bipolar |
|
|
Term
| Which drug blocks Na+ channels and increases action of GABA? |
|
Definition
|
|
Term
|
Definition
| blocks Na+ channels and increases action of GABA |
|
|
Term
| Which drugs ^ GABA-a action? |
|
Definition
|
|
Term
| Which drug is the first line in pregnant women and children? |
|
Definition
|
|
Term
| phenobarbital is 1st line in... |
|
Definition
| pregnant women and children |
|
|
Term
| Which drug ^ Na+ channel inactivation AND ^ GABA concentration? |
|
Definition
|
|
Term
|
Definition
| ^Na+ channel inactivation and ^ GABA concentration |
|
|
Term
| Which drug is also used for myoclonic seizures? |
|
Definition
|
|
Term
| valproic is also used for... |
|
Definition
|
|
Term
| which drug blocks thalamic T-type Ca2+ channels? |
|
Definition
|
|
Term
|
Definition
| blocks T-type thalamic Ca2+ channels |
|
|
Term
| which drug is also used for seizures of eclampsia? |
|
Definition
|
|
Term
| benzos are also used for seizures of... |
|
Definition
|
|
Term
| what is the first line agent to prevent seizures of eclampsia? |
|
Definition
|
|
Term
|
Definition
| 1st line agent to prevent seizures of eclampsia |
|
|
Term
| which drug inhibits GABA reuptake? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Which drug irreversibly inhibits GABA transaminase to increase GABA? |
|
Definition
|
|
Term
|
Definition
| irreversibly inhibits GABA transaminase to increase GABA |
|
|
Term
| Which drug has an unknown mechanism but may modulate GABA and glutamate release? |
|
Definition
|
|
Term
|
Definition
| unknown, may modulate GABA and glutamate release |
|
|
Term
| Most frequent route of metabolism |
|
Definition
|
|
Term
| Mechanisms of action for Phenytoin, Carbamazepine, Lamotrigine |
|
Definition
|
|
Term
| MOA for Valproic acid at high doses |
|
Definition
| Affect calcium, potassium, and sodium channels |
|
|
Term
| Drugs of choice for generalized tonic-clonic and partial seizures |
|
Definition
| Valproic acid and Phenytoin |
|
|
Term
|
Definition
|
|
Term
| Drugs of choice for absence seizures |
|
Definition
| Ethosuximide and valproic acid |
|
|
Term
| Drug of choice for myoclonic seizures |
|
Definition
|
|
Term
| Drugs that can be used for infantile spasms |
|
Definition
|
|
Term
| Anti-seizure drugs used also for bipolar affective disorder (BAD) |
|
Definition
| Valproic acid, carbamazepine, phenytoin and gabapentin |
|
|
Term
| Anti-seizure drugs used also for Trigeminal neuralgia |
|
Definition
|
|
Term
| Anti-seizure drugs used also for pain of neuropathic orgin |
|
Definition
|
|
Term
| Anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism |
|
Definition
|
|
Term
|
Definition
| Gingival hyperplasia, nystagmus, diplopia and ataxia |
|
|
Term
| Anti-seizure agent that induces formation of liver drug-metabolism enzymes, is teratogen and can cause craniofacial anomalies and spina bifida |
|
Definition
|
|
Term
| Agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and gastrointestinal distress |
|
Definition
|
|
Term
| Laboratory value required to be monitored for patients on valproic acid |
|
Definition
|
|
Term
|
Definition
| Aplastic anemia and acute hepatic failure |
|
|
Term
| Anti-seizure medication also used in the prevention of migraines |
|
Definition
|
|
Term
| Anti-seizure drugs used as alternative drugs for mood stabilization |
|
Definition
| Carbamazepine, gabapentin, lamotrigine, and valproic acid |
|
|
Term
| Which drugs INDUCE hepatic enzymes? |
|
Definition
| barbs, carbamazepine, phenytoin |
|
|
Term
| Which drug INHIBITS hepatic enzyme metabolism? |
|
Definition
|
|
Term
| Long term use of _____ is assoc with visual field defects |
|
Definition
|
|
Term
| Withdrawal is most difficult for which drugs? |
|
Definition
|
|
Term
| sulfonamides can displace _____ from its binding sites |
|
Definition
|
|
