Term
| Cholesterol Synthesis Inhibitors |
|
Definition
| Lovastatin, Pravastatin, Simvastatin, Fluvastatin, Atorvastatin, Rosuvastatin |
|
|
Term
|
Definition
| (familial) Hypercholesterolemia, Coronary atherosclerosis, prophylaxis. (Myopathy, rhabdomyolysis, hepatotoxicity, dermatomyositis) [Active liver disease, pregnancy/lactation] Lower LDL, combine with niacin for LDL (myopathic risk), gemfibrozil increases levels. Bile acid sequestrants are additive |
|
|
Term
| Atorvastatin and rosuvastatin |
|
Definition
|
|
Term
|
Definition
| least potent statin, processed by p450 but not 3A4 |
|
|
Term
| Lovastatin, simvastatin, atorvastatin |
|
Definition
|
|
Term
| Pravastatin and Rosuvastatin |
|
Definition
|
|
Term
| Bile Acid Absorption Inhibitors |
|
Definition
| Cholestyramine, Cholesevelam, Colestipol |
|
|
Term
| Bile Absorption Inhibitor Characteristics |
|
Definition
| Hypercholesterolemia (increase triglyceride levels, flatulence, vitamin K deficiency) [hyperlipidemia, biliary obstruction] Second-line agents |
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|
Term
|
Definition
|
|
Term
| Cholesterol Absorption Inhibitors |
|
Definition
|
|
Term
|
Definition
| (familial) Primary hypercholesterolemia, Sitosterolemia. (elevated liver function tests, myopathy, myalgia) [Liver disease, elevated tests with statin] compensatory increase in hepatic cholesterol synthesis, circulates enterohepatically, increased by cyclosporine and fibrates |
|
|
Term
|
Definition
| Gemribrozil, Fenofibrate: Hypertriglyceridemia, Type III dysbetalipoproteinemia (Elevated tests, myopathy, arrhythmias) [avoid with statins] first line hypertriglyceridemia, increase warfarin |
|
|
Term
|
Definition
| increases clearance of cyclosporine |
|
|
Term
|
Definition
| low HDL, Familial combined hyperlipidemia. (Hepatotoxicity, GI bleed, flushing) [Active liver disease] Flushing prevented with aspirin. Hyperuricemia and insulin resistance possible. |
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|
