Term
| Butyryl Pseudocholinesterase |
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Definition
| (plasma/liver) hydrolyzes procaine and succinylcholine |
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Term
|
Definition
| (NMJ Blocker) degrades SNAP-25 to prevent ACh release flacid paralysis + ↓ANS Tx Strabismus, blepharospasm, cervical dystonia, anal fissure, hyperhidrosis + Px migraines |
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Term
| Onabotulinum Toxin A Toxicity |
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Definition
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Term
|
Definition
| (ACh Ag; AChE-res) Dx Bronchial Asthma |
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Term
|
Definition
| (ACh Ag; AChE-res) Tx bladder/GI atony |
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Term
|
Definition
| (ACh Ag; AChE-res) Tx Xerostomia |
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Term
|
Definition
| (ACh Ag; AChE-res) Tx Xerostomia and Glaucome (increase trabecular outflow) |
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Term
|
Definition
| (Partial ACh Ag) smoking cessation |
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Term
| Organophosphorous Parathion/Malathion/Nitrostigmine Insecticides |
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Definition
| (irrev anti-AChE) phosphorylate Esteratic Ser + alkyl-loss aging inactive AChE |
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Term
|
Definition
| (irrev anti-AChE) phosphorylate Esteratic Ser + alkyl-loss aging inactive AChE |
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Term
|
Definition
| (Anti-Organophosphate) binds to Anionic site to conjugate with Esteratic Ser PO4 reactivates irrev-inib AChE Tx Organophosphorous and atropine poisoning |
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Term
|
Definition
| (rev Carbamate anti-AChE) locks carbamyl group to Esteratic Ser slow AChE MG Tensilon test (improves Myasthenci crisis / worsens Cholinergic) + Reverse NMJ blockers |
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Term
|
Definition
| (rev Carbamate anti-AChE) locks carbamyl group to Esteratic Ser slow AChE Tx MG, GI/Bladder Atony + Reverse NMJ blockers |
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Term
|
Definition
| (rev Carbamate anti-AChE) locks carbamyl group to Esteratic Ser slow AChE (CNS+ 3y Amine) Tx Glaucoma + Atropine poisoning |
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Term
|
Definition
| (rev Carbamate anti-AChE) locks carbamyl group to Esteratic Ser slow AChE (CNS— 4y Amine) Tx MG, Ileus, Urinary Retention + Px Sarin + Reverse NMJ blockers |
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Term
|
Definition
| (rev Carbamate anti-AChE) locks carbamyl group to Esteratic Ser slow AChE |
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Term
|
Definition
| (Anti-M) ↓Glands (compensatory cut vd due to ↑T), mydriasis/cycloplegia, smooth relaxation, CV Tachycardia (no ∆BP) Preanesthetic Bradycardia control + Tx Organophosphate poisoning |
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Term
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Definition
| hot as a hare, blind as a bat, dry as a bone, red as a beet, and mad as a hatter |
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Term
|
Definition
| (Anti-M) Tx motion sickness |
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Term
|
Definition
| (Anti-M) Preanesthetic Brady control |
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Term
|
Definition
| (Anti-M) Tx COPD, bronchial asthma |
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Term
|
Definition
| (Anti-M) Fundoscopic dilation |
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Term
|
Definition
| (Anti-M) Fundoscopic dilation |
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Term
|
Definition
| (Anti-M) Tx overactive bladder |
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Term
|
Definition
| (Anti-M) Tx overactive bladder |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| (Tricyclic antidepressant with anti-M + NET1 reuptake inhibitor) |
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Term
|
Definition
| (Tricyclic antidepressant with anti-M) |
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Term
|
Definition
| (Antipsychotic with anti-M) |
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Term
|
Definition
| (Antipsychotic with anti-M) |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| (anywhere) degrades post-NET1 NE (VMA + Metanephrine), DA, and Tyramine |
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Term
|
Definition
| MAO-A blockers (cheese severe HT) |
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Term
|
Definition
| MAO-A blockers (cheese severe HT) |
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Term
|
Definition
| (brain) degrades DA, NE, and 5-HT |
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
| (liver) degrades circ NE --> VMA + metanephrine |
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Term
|
Definition
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|
Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
| blocks NE granule storage |
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Term
|
Definition
| promotes NE/DA release @ CNS + block NET1 reuptake Alertness (ARAS), Concentration Tx Narcolepsy and narcolepsy |
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Term
|
Definition
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|
Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| B1 ino/chronotropism, low B2 vd / high a1 vc ↑BP, a/B ↓GIT smooth, a1 ↑bladder sphincter, B2 uterine relaxation, B2 Bronchodilation, a1 Mydriasis, B2 K uptake hypokalemia, B1 ↑Renin, a1/B GGL and lipolysis Tx anaphylaxis, asthma, glaucoma, and HyT (high dose) |
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Term
|
Definition
|
|
Term
|
Definition
| B1 ino/chronotropism --> Tx heart failure |
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Term
|
Definition
| a1 vc Tx Renal Failure shock |
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Term
|
Definition
| effectively ‘low dose DA’ @ D1R cAMP vd Tx HT crises |
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Term
|
Definition
| (B1 agonist) inotropism without chronotropism Tx acute heart failure + cardiogenic shock |
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Term
|
Definition
| (a/B agonist + NE release) MAO-resistant CNS stim Tx bronchial asthma, post-spinal anesthesia HyT, urinary incontinence |
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Term
|
Definition
| (a/B agonist + NE release) MAO-resistant CNS stim Tx bronchial asthma, post-spinal anesthesia HyT |
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Term
|
Definition
| (a1 agonist): a1 vc w/reflex bradycardia Tx Nasal congestion and induce Mydriasis |
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Term
|
Definition
| (non-selective B-agonists) B1 ino/chronotropism + B2 vd Tx Asthma and AV block |
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Term
|
Definition
| a1 vc, B1 ino/chronotropism + reflex bradycardia Tx HyT |
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Term
|
Definition
| (a-2 agonist) CNS inhibition of SNS + presynaptic NE inib Tx HT and ADHD |
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Term
|
Definition
| sedation, bradycardia, and rebound HT |
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Term
|
Definition
| converted to a-Methyl-NE in brain (a2 agonist) + direct inib of Dopa-decarboxylase (blocks DA/NA synth) DOC for Tx HT in prego |
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Term
|
Definition
| (B2 agonist) Bronchodilation Tx Bronchial asthma |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| (B2 agonist) Uterine relaxation |
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Term
|
Definition
| block vc, promote urination Tx Pheochromocytoma |
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Term
|
Definition
| failure of ejaculation, HyT/Postural HyT and reflex tachycardia |
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Term
|
Definition
| (irrev a-blocker) block vc, promoate urination Tx Pheochromocytoma |
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Term
|
Definition
| (rev a1 blocker) block vc, promote urination, promote good lipoproteins Tx Hypertension, BPH retention |
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Term
|
Definition
| first dose postural HyT; so we start with low dose at bed time to reduce it, failure of ejaculation |
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Term
|
Definition
| (rev a1 blocker) Tx Hypertension, BPH retention |
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Term
|
Definition
| (non-agonist B-blocker) ↓ino/chronotropism w/decreased AV conduction, ↓Aqueous humor production IOP, ↓Epi muscle tremors Tx Glaucoma, Tremors, Diabetic MI, Normal CV, HT, Hyperthyroidism + Px migraine and esophageal varices |
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Term
| Long term propranolol toxicity |
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Definition
| unfavorable ↑VLDL/↓HDL, sedation, depression, bronchial asthma, blocks signals/recover from hypoglycemia (but outweights risks in Diabetics with MI) |
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Term
|
Definition
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Term
|
Definition
| (non-agonist B-blocker) Tx hyperthyroidism |
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Term
|
Definition
| (intrinsic agonist B-blocker) |
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Term
|
Definition
| (B-blocker w/a-blocking) Most popular drug in CCF |
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Term
|
Definition
| (B-blocker w/a-blocking) Most popular drug in CCF |
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Term
|
Definition
| (B1 blocker w/no intrinsic activity) Tx CV in DM and Bronchial asthma |
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Term
|
Definition
| (B1 blocker w/no intrinsic activity) Tx CV in DM and Bronchial asthma |
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Term
| Metoprolol cessation toxicity |
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Definition
|
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Term
|
Definition
| (B1 blocker w/no intrinsic activity) |
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Term
|
Definition
| (B1 blocker w/no intrinsic activity) |
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Term
|
Definition
| (B1 blocker w/intrinsic Symp activity) No bradycardia or bronchoconstriction |
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Term
|
Definition
| (B1 blocker w/intrinsic Symp activity) No bradycardia or bronchoconstriction |
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Term
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Definition
| (Ganglion blocker) ↓predominant tone Tx HT crisis, dissecting aortic aneurysm + BLOCK reflex tachy/bradycardia |
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Term
|
Definition
| (Ganglion blocker) ↓predominant tone Tx HT crisis, dissecting aortic aneurysm + BLOCK reflex tachy/bradycardia |
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Term
|
Definition
| ESBL + resistance to aminoglycosides, quinolones, and sulfonamides |
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Term
|
Definition
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Term
|
Definition
| Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx Strep throat, RF, Syphillis + Px RF; pneumococcal resistance via ∆BP/Stap via B-lactamase |
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Term
|
Definition
| (PCNase-res PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx MSSA/MSSE ; causes interstitial nephritis + Staph resistance via ∆PBP |
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Term
|
Definition
| (PCNase-res PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx MSSA/E |
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Term
|
Definition
| (PCNase-res PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx MSSA/E; biliary excretion |
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Term
|
Definition
| (PCNase-res PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx MSSA/E; hepatitis |
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Term
|
Definition
| (PCNase-res PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx MSSA/E |
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Term
|
Definition
| (ER PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx Pneumococal pneumonia/OM, Moraxella OM, H. flu OM, E. coli UTI, and H. pylori; Px dental endocarditis |
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Term
|
Definition
| (ER PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx Pneumococal pneumonia, S. pyo, E. coli, H. pylori, Listeria, and Borellia; biliary excretion |
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Term
|
Definition
| Ticarcillin: (ER PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx Pseudomonas |
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Term
|
Definition
| Ticarcillin: (ER PCN) Binds PBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx Pseudomonas |
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Term
|
Definition
| blocks PCN urinary excretion |
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Term
|
Definition
| HSR without PCN-cross; Disulfiram Like EtOH NV |
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Term
|
Definition
| (G1) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Px dental endocarditis |
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Term
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Definition
| (G1) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis surgical Px + ST infxn |
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Term
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Definition
| (G1) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis surgical Px + ST infxn |
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Term
|
Definition
| (G2) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis intra-abdominal infxn |
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Term
|
Definition
| (G2) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis intra-abdominal infxn |
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Term
|
Definition
| (G2) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis intra-abdominal infxn |
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Term
|
Definition
| (G2) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis intra-abdominal infxn |
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Term
|
Definition
| (G2) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx Anaerobes + intra-abdominal infxn |
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Term
|
Definition
| (G2) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx ESBLs, Anaerobes + intra-abdominal infxn |
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Term
|
Definition
| (G3) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis good for CNS |
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Term
|
Definition
| (G3) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis good for CNS |
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Term
|
Definition
| (G3) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis good for CNS |
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Term
|
Definition
| (G3) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis good for CNS |
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Term
|
Definition
| (G3) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis good for CNS Pseudomonas infxn |
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Term
|
Definition
| (G3) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Px H.flu/N.mening meningitis, DOC for Tx of Borellia, serious non-Anarobe Pediatric infxn; good for CNS, Biliary excretion/sludging |
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Term
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Definition
| (G4) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis good for G- |
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Term
|
Definition
| (Monobactam) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis G- resistants |
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Term
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Definition
| (Carbapenem) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Admin with CIlastatin to inib renal dehydropeptidase1 degen Tx suspect resistant crashes; can cause seizures/renal failure |
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Term
|
Definition
| (Carbapenem) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx suspect resistant crashes |
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|
Term
|
Definition
| (Carbapenem) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx suspect resistant crashes |
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Term
|
Definition
| (Carbapenem) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Tx suspect resistant crashes |
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Term
|
Definition
| (Carbapenem) Binds BLBP to ↓transpeptidase peptidoglycan cross-linking + ↑Autolysis Admin with CIlastatin to inib renal dehydropeptidase1 degen Tx suspect resistant crashes; can cause seizures/renal failure |
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Term
|
Definition
| rreversibly inib biosynthesis of CW peptidoglycan polymers in G+ DOC for MRSA/E, PCN res pneumococci/enterococci + DO2C for C. difficile + Px CNS shunt surg; ∆BP resistance + severe renal and red-man toxicity |
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Term
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Definition
| uniquely conc-dep cidal inhibition of peptidoglycan and LTA synth in CW Tx G+ Vancomycin/Lenizolid resistant (designed not to allow MOR) in adults only |
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Term
|
Definition
| transient muscle weakness/myalgias |
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Term
|
Definition
| worse with acidosis + best with B-lactams |
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Term
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Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
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Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
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Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
|
Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
|
Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
|
Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
|
Definition
| (aminoglycoside) Bind 30S to cidally block initiation complex/mRNA template Tx Mycobacterial + empiric neonatal E. coli/S. Agalactiae meningitis; MOR ∆30S + ototoxicity + NMJ block |
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Term
| Tetracyclines and B-lactams |
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Definition
|
|
Term
|
Definition
| (tetracyclines) Binds 30 to statically block aminoacyl-tRNA attachment/elongation Tx Mycoplasma, Chlamydia, Chancroid, and DOC for Rickettsia RMSF; MOR Efflux + Fetal/Ped bone and teeth + Pseudotumor cebri |
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Term
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Definition
| (tetracyclines) Binds 30 to statically block aminoacyl-tRNA attachment/elongation Tx Mycoplasma, Chlamydia, Chancroid, and Rickettsia RMSF; MOR Efflux + Fetal/Ped bone and teeth + Pseudotumor cebri |
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Term
|
Definition
| (tetracyclines) Binds 30 to statically block aminoacyl-tRNA attachment/elongation Tx Mycoplasma, Chlamydia, Chancroid, and DOC for Rickettsia RMSF; MOR Efflux, fecal excretion + Fetal/Ped bone and teeth + Pseudotumor cebri |
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Term
|
Definition
| (tetracyclines) Binds 30 to statically block aminoacyl-tRNA attachment/elongation Tx Mycoplasma, Chlamydia, Chancroid, and Rickettsia RMSF; MOR Efflux + Fetal/Ped bone and teeth + Pseudotumor cebri |
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Term
|
Definition
| massive CK response in cidal killing of rickettsia, spiroketes, G-, and parasites |
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Term
|
Definition
| bind 30S to statically block amino-acyl tRNA Tx MRSA/E, VRE, resistant pneumo/enterococci in ADULTS |
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Term
|
Definition
| binds 50S to statically block peptidyl transferase broad spectrum but feared toxicity (aplastic anemia, gray baby syndrome non-glucoridation) |
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Term
|
Definition
| Cardiotoxicity/Pyloric stenosis in infants |
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Term
|
Definition
| (Macrolide) concentrates in phagocytic cells to bind 50S statically and prevent transpeptidase Tx DOC for Mycoplasma; CI prego |
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Term
|
Definition
| (Macrolide) concentrates in phagocytic cells to bind 50S statically and prevent transpeptidase Tx Atypical Mycobacteria, Legionella; CI prego |
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Term
|
Definition
| Azithromycin: (Macrolide) concentrates in phagocytic + resp cells to bind 50S statically and prevent transpeptidase Tx DOC for Typhoid Fever and Pertussis; OK for prego |
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Term
|
Definition
| (Macrolide) concentrates in phagocytic cells to bind 50S statically and prevent transpeptidase Tx Pertusis, Legionella; CI prego |
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Term
|
Definition
| blurred vision, prolonged QT, worse MG |
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|
Term
|
Definition
| (lincosamide) bind 50S statically and prevent transpeptidase Tx Anaerobes |
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Term
|
Definition
| binds 50S cidally and prevents transpeptidase |
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Term
|
Definition
| drug interaxns, phlebitis, jaundice, arthr/myalgia |
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|
Term
|
Definition
| good penetration into lung to Tx pneumonia (better than Vancomycin) Binds 50S at unique site to statically inhibit transpeptidase/initiaiton Tx VRE, VRS, and VRSA;MOR ∆50S |
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Term
|
Definition
| Hyperseratoinin interaction with SSRI headache, syncope, palpitations, and lacticacidosis |
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Term
|
Definition
| (sulfonamides) bacteriostatic inhibition of Dihydropteroate synthetase |
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Term
|
Definition
| (sulfonamides) bacteriostatic inhibition of Dihydropteroate synthetase |
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|
Term
|
Definition
| Sulfiaziazine: (sulfonamides) bacteriostatic inhibition of Dihydropteroate synthetase |
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Term
|
Definition
| (Sulfa + Trimethroprim) sequential bacteriostatic blockade of Dihydropteroate synthetase + dihydrofolate reductase Tx Toxoplasma (with pyrimethamine), Pneumocystis, and Uncomplicated UTI + Px RF in PCN-allergic ; MOR met bypass (PABA) |
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Term
|
Definition
| Steven's Johnson syndrome, Kernicterus |
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Term
|
Definition
| absorption hindered by antacids |
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Term
|
Definition
| Achilles rupture and fetal/ped articular cartilage injury |
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Term
|
Definition
| (G1Q) Cidal inhibition of DNA Gyrase (TI2/4) Tx GC UTI, prostatitis Osteomyelitis, and CAP/VAP; MOR ∆DNAG |
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Term
|
Definition
| (G2Q) Cidal inhibition of DNA Gyrase (TI2/4) Tx GC UTI, prostatitis Osteomyelitis, and CAP/VAP ; MOR ∆DNAG |
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Term
|
Definition
| (G2Q) Cidal inhibition of DNA Gyrase (TI2/4) Tx GC UTI, prostatitis Osteomyelitis, and CAP/VAP ; MOR ∆DNAG |
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|
Term
|
Definition
| (G3Q) Cidal inhibition of DNA Gyrase (TI2/4) Tx GC UTI, prostatitis Osteomyelitis, and CAP/VAP; MOR ∆DNAG |
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|
Term
|
Definition
| (G4Q) Cidal inhibition of DNA Gyrase (TI2/4) Tx GC UTI, prostatitis Osteomyelitis, and CAP/VAP; MOR ∆DNAG |
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Term
|
Definition
| (SS analog) Tx acromegaly, carcinoid/VIPoma, and Thyrotropic adenomas |
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|
Term
|
Definition
| (SS analogy) Tx acromegaly in euthyroid individuals |
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|
Term
|
Definition
| (DA agonist) Tx hyperprolactinemia, Parkinsonism, and Acromegaly |
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|
Term
|
Definition
| (DA agonist) Tx hyperprolactinemia, Parkinsonism, and Acromegaly |
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|
Term
|
Definition
| Psychiatric, Raynaud's, and Orthostatic HyT due to NE inib |
|
|
Term
|
Definition
| (low dose pulsatile GnRH agonist) ↑FSH/LH Tx hypothalamic amenorrhea + Dx pituitary amenorrhea |
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|
Term
|
Definition
| (high dose continuous GnRH agonist) 2wk ↑LH/FSH flare + prolonged ↓LH/FSH, leading to ↓Androgens/Estrogens Tx prostate/breast cancer, precocious puberty, endometriosis (causes infertility), and cyclical AIP |
|
|
Term
|
Definition
| (high dose continuous GnRH agonist) 2wk ↑LH/FSH flare + prolonged ↓LH/FSH, leading to ↓Androgens/Estrogens Tx prostate/breast cancer, precocious puberty, endometriosis (causes infertility), and cyclical AIP |
|
|
Term
|
Definition
| (high dose continuous GnRH agonist) 2wk ↑LH/FSH flare + prolonged ↓LH/FSH, leading to ↓Androgens/Estrogens Tx prostate/breast cancer, precocious puberty, endometriosis (causes infertility), and cyclical AIP |
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|
Term
|
Definition
| (high dose continuous GnRH agonist) 2wk ↑LH/FSH flare + prolonged ↓LH/FSH, leading to ↓Androgens/Estrogens Tx prostate/breast cancer, precocious puberty, endometriosis (causes infertility), and cyclical AIP |
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Term
|
Definition
| (continuous GnRH antagonist) ↓LH/FSH but no 2wk flare ↓Androgens/Estrogens ART to prevent premature ovulation |
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Term
|
Definition
| (continuous GnRH antagonist) ↓LH/FSH but no 2wk flare ↓Androgens/Estrogens ART to prevent premature ovulation |
|
|
Term
|
Definition
| (continuous GnRH antagonist) ↓LH/FSH but no 2wk flare ↓Androgens/Estrogens ART to prevent premature ovulation + Tx Prostate Cancer |
|
|
Term
|
Definition
| (CRH analog) DDx of non-Dexamethasone suppressed 2y hypercortisolism (Cushings will worsen / Ectopic ACTH will not) |
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Term
|
Definition
| stimulation test to DDx 2y adrenal insufficiency (no correction) or 3y adrenal insufficiency (correction) |
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Term
|
Definition
| Tx GH def, AIDS wasting, osteoporosis, and short stature |
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Term
|
Definition
| slipped femoral epiphysis + CJD + ↑cortisol metabolism 2y hypoadrenal unmasking |
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|
Term
|
Definition
| (IGF-1 prep) Tx GH-insensitive Laron Dwarfism |
|
|
Term
|
Definition
| (GH-R Antagonist) Tx Acromegaly (can cause hypoglycemia) |
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|
Term
|
Definition
| (LH agonist) induces ovulation Tx hypogonadotropic hypogonadal anovulation, PCOS, cryptorchidism |
|
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Term
|
Definition
| (porcine ACTH) Tx infant spasms + Dx CAH enzyme deficiency or Adrenal insufficiency |
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Term
|
Definition
| (oxytocin prep) uterine contraction induce labore + reduce postpartum hemorrhage |
|
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Term
|
Definition
| (oxytocin antagonist) Tx/suppress premature labor |
|
|
Term
|
Definition
| (ADH analog @ V1R) universal vc Tx esophageal varices + catecholamine-res shock |
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Term
|
Definition
o 2wk flare ↓Androgens/Estrogens ART to prevent premature ovulation
Cetrorelix: (continuous GnRH antagonist) ↓LH/FSH but no 2wk flare ↓Androgens/Estrogens ART to prevent premature ovulation
Abarelix: (continuous GnRH antagonist) ↓LH/FSH but no 2wk flare ↓Androgens/Estrogens ART to prevent premature ovulation + Tx prostate cancer
Corticorellin: (CRH analog) DDx of non-Dexamethasone suppressed 2y hypercortisolism (Cushings will worsen / Ectopic ACTH will not)
CRH: stimulation test to DDx 2y adrenal insufficiency (no correction) or 3y adrenal insufficiency (correction)
Recombinant GH: Tx GH def, AIDS wasting, osteoporosis, and short stature
- AE: slipped femoral epiphysis + CJD + ↑cortisol metabolism 2y hypoadrenal unmasking
Mecasermin: (IGF-1 prep) Tx GH-insensitive Laron Dwarfism
Pegvisomant: (GH-R Antagonist) Tx Acromegaly
- AE: Hypoglycemia due to IGF1 inib
hCG: (LH agonist) induces ovulation Tx hypogonadotropic hypogonadal anovulation, PCOS, cryptorchidism
Cosyntropin: (porcine ACTH) Tx infant spasms + Dx CAH enzyme deficiency or Adrenal insufficiency
Pitocin: (oxytocin prep) uterine contraction induce labore + reduce postpartum hemorrhage
- AE: seizure and hyponatremia
Atosiban: (oxytocin antagonist) Tx/suppress premature labor
Terlipressin: (ADH analog @ V1R) universal vc Tx esophageal varices + catecholamine-res shock
Desmopressin: (ADH analog @ V2R) aquaporins @ CD + F8/vWF Tx Nocturnal enuresis, DI, hemophilia, and vWD |
|
|
Term
|
Definition
| (non-selective V1/2R antagonist) Tx hyponatremia in SIADH |
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|
Term
|
Definition
| (non-selective V1/2R antagonist) Tx hyponatremia in SIADH |
|
|
Term
|
Definition
| (glucocorticoid) HRT in 1y/2y hypoadrenalism or CAH |
|
|
Term
|
Definition
| (glucocorticoid) Tx maturation of premie lungs or Dx 2y/3y hyperadrenalism due to lack of ACTH suppression |
|
|
Term
|
Definition
| (glucocorticoid) Tx maturation of premie lungs |
|
|
Term
|
Definition
| (gluco/mineralocorticoid) Tx salt wasting CAH |
|
|
Term
|
Definition
| (glucocorticoid) Tx AI, transplant, lymphoma/leukemia, and bronchial asthma (OK for prego) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| (11B-OH inib) Tx Cushings |
|
|
Term
|
Definition
| salt/water retention + hirsutism due to shifts |
|
|
Term
|
Definition
| low dose progesterone antagonist (49 day abortion) + high dose anti-glucocorticoid activity |
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Term
|
Definition
| mineralocorticoid + androgen antagonist Tx hyperaldosteronism + hirsutism |
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Term
|
Definition
| mineralocorticoid antagonist --> Tx HT |
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|
Term
|
Definition
| (3B-OH inib) blocks all corticosteroid and androgen synthesis |
|
|
Term
|
Definition
| blocks cholpregenolone + inhibits aromatase Tx cushings or breast cancer |
|
|
Term
|
Definition
| blocks CYP17 @ low dose (no androgens) + CYP11 @ high dose (no glucocorticoids) Tx hypercortisolism (high dose) and BPH (low) |
|
|
Term
|
Definition
| (synthetic estrogen) Tx female hypogonadism, menopause, and contraception |
|
|
Term
|
Definition
| (synthetic estrogen) Tx female hypogonadism, menopause, and contraception |
|
|
Term
|
Definition
| gall stones, pulm emboli, cancer |
|
|
Term
|
Definition
| (SERM) antagonist @ hypothal/pituitary ↑FSH/LH induce ovulation |
|
|
Term
|
Definition
| (SERM) agonist @ bone, blood, and endometrium + antagonist @ breast Tx breast cancer |
|
|
Term
|
Definition
| (SERM) agonist @ bone, blood, and endometrium + antagonist @ breast Tx breast cancer |
|
|
Term
|
Definition
| (SERM) agonist @ bone, blood + antagonist @ breast/endometrium Tx osteoporosis |
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|
Term
|
Definition
| CYP19 aromatase inib ↓estrogens Tx postmenopausal breast cancer + ovulatory induction |
|
|
Term
|
Definition
| CYP19 aromatase inib ↓estrogens Tx postmenopausal breast cancer + ovulatory induction |
|
|
Term
|
Definition
| CYP19 aromatase inib ↓estrogens Tx postmenopausal breast cancer + ovulatory induction |
|
|
Term
|
Definition
| (synthetic progestin) Tx HRT, contraception, ↓endometrial cancer, ↑AIDS |
|
|
Term
|
Definition
| (synthetic progestin) Tx HRT, contraception, ↓endometrial cancer, ↑AIDS |
|
|
Term
|
Definition
| (synthetic progestin) Tx HRT, contraception, ↓endometrial cancer, ↑AIDS |
|
|
Term
|
Definition
| (synthetic progestin) Tx HRT, contraception, ↓endometrial cancer, ↑AIDS |
|
|
Term
|
Definition
| (androgen prep) Tx hypogonadism and endometriosis |
|
|
Term
|
Definition
| (weak androgen synth) anti-estrogenic Tx endometriosis + Px hereditary angioedema |
|
|
Term
|
Definition
| (androgen-R antag) prevent androgenic AE of high dose GnRH-agonist Tx of prostate cancer |
|
|
Term
|
Definition
| (androgen-R antag) prevent androgenic AE of high dose GnRH-agonist Tx of prostate cancer |
|
|
Term
|
Definition
| (5a-reductase inib) ↓DHT Tx BPH and male pattern baldness |
|
|
Term
|
Definition
| (5a-reductase inib) ↓DHT Tx BPH and male pattern baldness |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| injectable Amylin that slows gastric emptying and inhibits glucagon secretion |
|
|
Term
|
Definition
| injectable protease resistant Incretin (GLP1/GIP) that ↓glucagon release + ↑glu-dep insulin release |
|
|
Term
|
Definition
| (G1SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (G1SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (G1SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (G2SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (G2SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (G2SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (G2SU) insulin secretagogue via locking K-Ch closed + enhanced sensitivity/↓GGL Tx non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| hypoglycemia potentiated by Sulfonamids, B-blockers, EtOH, MAO inib |
|
|
Term
|
Definition
| (Meglitinide) faster/shorter insulin seretagogue Tx non-ketotic T2DM that is unmanageable with diet alone (can also cause hypoglycemia) |
|
|
Term
|
Definition
| (DDP4-inib) ↑incretins ↑insulin/↓glucagon mono-Tx + exercise for non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (DDP4-inib) ↑incretins ↑insulin/↓glucagon mono-Tx + exercise for non-ketotic T2DM that is unmanageable with diet alone |
|
|
Term
|
Definition
| (Biguanide) oral insulin sensitizer + decrease CV RFs Tx T2DM in obese/elderly |
|
|
Term
|
Definition
| fatal lacticacidosis in EtOHism/renal insufficiency |
|
|
Term
|
Definition
| (Glyburide + Metformin) combo Tx; can cause drop in HbA1x |
|
|
Term
|
Definition
| (Thiazolidenione) oral insulin sensitizer ↑Glu/carb metabolism Tx severely insulin-resistant T2DM |
|
|
Term
|
Definition
| (Thiazolidenione) oral insulin sensitizer ↑Glu/carb metabolism Tx severely insulin-resistant T2DM |
|
|
Term
|
Definition
| severe hepatotoxicity and CV risk |
|
|
Term
|
Definition
| a-glucosidase inhibitor taken before meals as adjunct to sulfonylurea/insulin to delay (low dose) or inhibit (high dose) digestion of ingested carbs |
|
|
Term
|
Definition
| oral hyperglycemic benzothiadiazene anti-HT derivative with antidiuretic activity prevent K Ch closure in B cells potent hyperglycemia due to inhibition of insulin secretion |
|
|
Term
|
Definition
| (bisphosphonate) bind surface (↓recruitment) + enter OC ↓farnesyl diphosphate synthase (↓activity) + ↑tox ATP analogue metabolite (apoptosis)↑mineralization/BMD1st line Tx/ |
|
|
Term
|
Definition
| osteonecrosis + acid reflux |
|
|
Term
|
Definition
| cheap partial Tx Osteoporosis, Osteomalacia/Ricketts, Renal Failure, Malabs, and psoriasis |
|
|
Term
|
Definition
| (Calcitonin) ↓OC + ↑renal excretion of Ca/PO4/Na/Mg/K via inib reabsorption ↑BMD (esp spine) + rapid fall in Ca Tx Hypercalcemia, Osteoporosis for bisphosphonate inteolerant |
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|
Term
|
Definition
| fully human antagonistic mAb @ RANKL ↓resorption ↓fractures Tx PM osteoporosis ~ efficacy as bisphosphonates |
|
|
Term
|
Definition
| Jaw osteonecrosis + hypocalcemia/magnesia/phosphatemia |
|
|
Term
|
Definition
| last ditch (bad AE) but very effective PM Px osteoporosis + Tx menopause vasomotor/vulvovaginal atrophy |
|
|
Term
|
Definition
| (PTH) ↑OC/OC, GI Ca absorption/reabsorption EXPENSIVE Tx of SEVERE PM/hypogonadal osteoporosis who can’t tolerate/are refractory (>3mo) to Bisphosphonates |
|
|
Term
|
Definition
| (PTH) ↑OC/OC, GI Ca absorption/reabsorption EXPENSIVE Tx of SEVERE PM/hypogonadal osteoporosis who can’t tolerate/are refractory (>3mo) to Bisphosphonates |
|
|
Term
|
Definition
| non-hormonal Px/Tx osteoporosis via ↓fracture risk in elderly after stroke (elevated homocysteiene) |
|
|
Term
|
Definition
| modest non-hormonal Tx osteoporosis in PM women with HT |
|
|
Term
|
Definition
| synthetic steroid with estrogenic (AE: breast/endometrial cancer) /androgenic/progestagenic properties ↑BMD |
|
|
Term
|
Definition
| (Ethanolamine 1st gen H1R Antagonist) Sedative and antimuscarinic activity --> Tx Parkinsons, Motion sickness, and Prego NV |
|
|
Term
|
Definition
| (Ethylenediamines 1st gen H1R Antagonist) Sedative and antimuscarinic activity --> Tx Parkinsons, Motion sickness, and Prego NV |
|
|
Term
|
Definition
| (Alkylamines 1st gen H1R Antagonist) Sedative and antimuscarinic activity --> Tx Parkinsons, Motion sickness, and Prego NV |
|
|
Term
|
Definition
| (Phenothiazines 1st gen H1R Antagonist) Sedative and antimuscarinic activity --> Tx Parkinsons, Motion sickness, and Prego NV |
|
|
Term
|
Definition
| (Piperazine 2nd gen H1R Antagonist) |
|
|
Term
|
Definition
| (Piperadine 2nd gen H1R Antagonist) |
|
|
Term
|
Definition
| (Piperadine 2nd gen H1R Antagonist) |
|
|
Term
|
Definition
| (Piperadine 2nd gen H1R Antagonist) |
|
|
Term
|
Definition
| (Piperadine 2nd gen H1R Antagonist) |
|
|
Term
|
Definition
| (Piperadine 2nd gen H1R Antagonist) metabolite of terfenadine/astemizole, but does not carry cardiotoxicity |
|
|
Term
|
Definition
| Anti-M, teratogenesis, and Torsades de Pointes |
|
|
Term
|
Definition
| (H2R Antagonist) Tx peptic ulcers, GERD, ZE |
|
|
Term
|
Definition
| (H2R Antagonist) Tx peptic ulcers, GERD, ZE |
|
|
Term
|
Definition
| (H2R Antagonist) Tx peptic ulcers, GERD, ZE |
|
|
Term
|
Definition
| (H2R Antagonist) Tx peptic ulcers, GERD, ZE |
|
|
Term
|
Definition
| diarrhea, dizziness, and anti-androgen binding effects |
|
|
Term
|
Definition
| CNS somnolence/delirium in elderly + ↓P450/hepatic Q toxicity for Warfarn, B-blockers, Ca-Ch blockers, Lidocaine, and Phenytoin |
|
|
Term
|
Definition
| ↑5-HT release from platelets/CNS |
|
|
Term
|
Definition
| banned cardiotoxic appetite suppressants due to increased 5-HT release |
|
|
Term
|
Definition
| banned cardiotoxic appetite suppressants due to increased 5-HT release |
|
|
Term
|
Definition
| (SSRI) ↓5-HT reuptake as Tx for endogenous depression/OCD |
|
|
Term
|
Definition
| 1B/D/E agonist intracranial vc (AE: coronary vc chest pain) to prevent dural extravasation Tx migraine |
|
|
Term
|
Definition
| Tx nausea/motion sickness by inhibiting 5-HTR3 (only ionotropic) |
|
|
Term
|
Definition
| PGE1 analog vd, ↓Agg, uterine contraction, and intestinal contraction (AE: bradycardia, HyT, fever) |
|
|
Term
|
Definition
| PGE1 analog inhibits gastric ulcers (causes gastric pain) |
|
|
Term
|
Definition
| PGE2 analog induces uterine contraction to facilitate labor (AE: NVD, fever, and bronchoconstriction) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| PGI2 ↓BP in pulm HT (AE: nausea, headache, HyT) |
|
|
Term
|
Definition
| reversibly (indomethacin, Ibuprofen, Naproxen) ↓COX1/2 (aspirin/acetylsalicylic acid = irreversible + low dose thrombosis/MI Px) anti-inflammatory, antipyretic, analgesis, and anti-agg (potentiates anticoag) |
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|
Term
|
Definition
| blocks COX3 and COX1/2 weakly antipyretic/analgesic @ CNS but NOT anti-inflammatory or anti-agg |
|
|
Term
|
Definition
| selectively blocks COX2 to inhibit local inflammatory response but not against GI/urinary protective (reduced GI and urinary irritation/ulceration) antipyretic, analgesic BUT NO ↓agg Tx arthritis |
|
|
Term
|
Definition
| selectively blocks COX2 to inhibit local inflammatory response but not against GI/urinary protective (reduced GI and urinary irritation/ulceration) antipyretic, analgesic BUT NO ↓agg Tx arthritis |
|
|
Term
|
Definition
| selectively blocks COX2 to inhibit local inflammatory response but not against GI/urinary protective (reduced GI and urinary irritation/ulceration) antipyretic, analgesic BUT NO ↓agg Tx arthritis |
|
|
Term
|
Definition
| increased risk of MI (esp Rofecoxib… why? Can’t be because Naproxen is THAT protective) |
|
|
Term
|
Definition
| blocks lipoxygenase (esp Bronchoconstrictive LTs) Tx ulcerative colitis, asthma, and allergic rhinitis |
|
|
Term
|
Definition
| LT-R antagonists Asthma Tx |
|
|
Term
|
Definition
| LT-R antagonists Asthma Tx |
|
|
Term
| NOnselective COX inib @ heart |
|
Definition
| prevents TXA2 synthesis and some PGI2 synthesis high PGI2/TXA2 ration less clotting beneficial! |
|
|
Term
| Selective COX2 inib @ heart |
|
Definition
| prevents PGI2 synth, thus causing massive shift to TXA2 synth via COX1 low PGI2/TXA2 ratio MORE clotting harmful |
|
|
Term
|
Definition
| PAF antagonist that interferes with ovulation/implantation |
|
|
Term
|
Definition
| FF derivative of ARA-release via lyso-PAF acetyltransferase metabotropic stim of PLA2/C/D vd, vperm (1000x histamine), hyperalgesia, bronchospasm platelet/PMN agg, LT release/SO killing, GI contraction/ulcers (most ulcerogenic known), ovulation/implantation |
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|
Term
|
Definition
| (Thioamide) inhibits TPO organification/coupling of iodine to Tyrosines + peripheral deiodinase D1 conversion of T4 to T3 choice Tx for prego/thyrotoxic crisis |
|
|
Term
|
Definition
| COMMON pruritic mp rash, rare Agranulotycosis |
|
|
Term
|
Definition
| (Thioamide) (10x more potent than Propylthiouracil – used to ↓degree prior to subtotal thyroidectomy/rad-Iodine Tx) inhibits TPO organification/coupling of iodine to Tyrosines but INEFFECTIVE @ blocking deiodinase D1 |
|
|
Term
|
Definition
| COMMON pruritic mp rash, long term thyroid hyperplasia, and rare reversible agranulocytosis |
|
|
Term
|
Definition
| (prep for thyroid surgery + rapid short-term improvement of Thyroid storm)↓synth and release of T3/4 + ↓size/vascularity of thyroid |
|
|
Term
|
Definition
| RAAARE hypothyroidism T-HRT acneiform rash, swollen salivar glands/mucosal ulcerations, and fetal goiters |
|
|
Term
|
Definition
| (single oral dose used when thyroidectomy is contraindicated, multinodular hyperthyroidism, or toxic adenomas in Pts who have become Euthyroid or are on Blockers) uptake + destruction @ thyroid via short-penetrating B-rays with 5-day half-life (little collateral damage) OR uptake Dx test to evaluate fxn |
|
|
Term
| B-adr blockers (propranolol) in thyrotoxic crisis |
|
Definition
| (widely used) control CV s/s ~ tachycardia, HT, and a-fib |
|
|
Term
|
Definition
| asthma, AV blockade, HyT, bradycardia |
|
|
Term
|
Definition
| excessive TH or discontinuing Anti-thyroid meds hyperglycemia (high output/low use) + Insulinopenia (high pancreatic proinsulin output + renal clearance) Diabetic Ketoacidosis |
|
|
Term
|
Definition
| Propylthiouracil (long term) + Propranolol (minimize cardio) + Na/KI (short term) |
|
|
Term
|
Definition
| (cidal) cleaved by KatG catalase ↓InhA mycolic acid synth |
|
|
Term
|
Definition
| Sideroblastic Anemia and urine color change |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| red body fluids and decreased activity of other drugs |
|
|
Term
|
Definition
| (static/cidal) ↓arabinosyl transferase ↓arabinogalactan polysaccharide layer that attaches mycolic acid shell to PM |
|
|
Term
|
Definition
| retrobulbar neuritis with central scotomas and hyperuricemia |
|
|
Term
|
Definition
| (cidal) sterilizing agent converted to active pyrazinoic acid in Mφ lysosomes ↓FA synthase 1 |
|
|
Term
|
Definition
| hyperuricemia/gouty arthritis (CI by gout) and hepatotoxicity |
|
|
Term
|
Definition
|
|
Term
|
Definition
| (supplementary for TB Tx) binds S12 cidally for use when injectable drug needed for resisitant strains |
|
|
Term
|
Definition
|
|
Term
|
Definition
| hemolytic anemia, dapsone syndrome (fever, LAN, exfoliative dermatitis, hep, and mp rash pot fatal), and agranulocytosis |
|
|
Term
|
Definition
| only highly bactericidal against M. leprae |
|
|
Term
|
Definition
| binds DNA guanine bases to block DNA template + ↑PLA2 causing accum of toxic phospholipids |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Drug of choice for both treatment and chemoprophylaxis of malaria but compromised against Falciparum due to resisitance |
|
|
Term
|
Definition
| accumulates in food vacuoles DNA incorporation inhibits proliferation + ↑pH ↓protease cleavage of heme to hemozone parasite toxicity |
|
|
Term
|
Definition
| solely blood shizonticide to IV in sever infxn and chloroquine=resistant falciparum (esp cerebral) + Babesiosis |
|
|
Term
|
Definition
| Cinchonism (GI, vertigo, tinnitus, blurred vision, cardiac conduction, and G6PD hemolysis) |
|
|
Term
|
Definition
| first line drug for areas with chloroquine resistance from P falciparum |
|
|
Term
|
Definition
| psychiatric/neuro/seizures |
|
|
Term
|
Definition
| combined for radical cure of vivax/ovale dormant liver forms/gametocytes via oxidant metabolites (should be used with quinine) |
|
|
Term
|
Definition
| R* killers against resistant falciparum |
|
|
Term
| Dihydropteroate Synthetase inib in Malaria |
|
Definition
|
|
