Term
| bidi goes to camp behave. What does this mean? |
|
Definition
bidi = "B1D1"
to = 2
BeHaVe = BHV
b1, D1, b2, H2, V2 -- these receps increase cAMP |
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Term
| You're GQ, have 1 M&M - what does this mean? |
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Definition
| H1, a1, V1, M1, M2 - these use Gq -> IP3 and DAG |
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Term
| Name the first generation H1 blockers |
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Definition
| diphenhydramine, chlorpheniramine |
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Term
| diphenhydramine, chlorpheniramine - what are these? |
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Definition
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Term
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Definition
| smooth muscle, endothelium, brain |
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Term
| smooth muscle, endothelium, brain have H__ recepts |
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Definition
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Term
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Definition
| gastric mucosa, cardiac muscle, mast cells, brain |
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Term
| gastric mucosa, cardiac muscle, mast cells, brain have H__ recepts |
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Definition
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Term
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Definition
| presyn: brain, myenteric plexus, other neurons |
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Term
| presyn: brain, myenteric plexus, other neurons have H__ receptors |
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Definition
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Term
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Definition
| eosinophils, neutrophils, CD4+ T cells |
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Term
| H3 H4 shut the door - what does that mean? |
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Definition
| H3 and H4 are inhibitory - Gi |
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|
Term
| eosinophils, neutrophils, CD4+ T cells have H__ recepts |
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Definition
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Term
| therapy for serotonin syn? |
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Definition
| sedation, paralysis, intubation |
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|
Term
| therapy for neuroleptic malig syn? |
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Definition
|
|
Term
| Effects of diphenhydramine? |
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Definition
| reduce or prevent H effects on smooth muscle, immune cells, also blocks M and alpha, highly sedative |
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Term
| reduce or prevent H effects on smooth muscle, immune cells, also blocks M and alpha, highly sedative -- NAME THE DRUG |
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Definition
|
|
Term
| clinical applications of diphenhydramine? |
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Definition
| IgE immediate allergies, esp hay fever, urticaria, some use as sedative, anti-emetic, anti-motion sickness |
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Term
| IgE immediate allergies, esp hay fever, urticaria, some use as sedative, anti-emetic, anti-motion sickness -- NAME THE DRUG |
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Definition
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|
Term
|
Definition
| sedation, M blockade, ortho hypo, some inhibition of CYP2D6, may prolong some b-blockers |
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Term
| Tox: sedation, M blockade, ortho hypo, some inhibition of CYP2D6, may prolong some b-blockers -- NAME THE DRUG |
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Definition
|
|
Term
| how does chlorpheniramine compare to diphenhydramine? |
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Definition
| chlorpheniramine, less sedating, fewer autonomic effects |
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Term
| Which drug is an H1 blocker with less sedating and autonomic effects? |
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Definition
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|
Term
| Name the second gen H1 blockers |
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Definition
| cetirizine, loratidine, fexofenadine |
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|
Term
| cetirizine, loratidine, fexofenadine - what are these? |
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Definition
|
|
Term
|
Definition
| reduce or prevent H effects on smooth muscle and immune cells |
|
|
Term
| reduce or prevent H effects on smooth muscle and immune cells-- NAME THE DRUG |
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Definition
|
|
Term
| cetirizine - applications? |
|
Definition
| IgE immediate allergies, hay fever, urticaria |
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|
Term
| for IgE immediate allergies, hay fever, urticaria -- NAME THE DRUG |
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Definition
|
|
Term
|
Definition
| sedation and arrhythmias in OD |
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|
Term
| sedation and arrhythmias in OD - NAME THE DRUG |
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Definition
|
|
Term
| loratadine and fexofenadine are like... |
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Definition
|
|
Term
| Which drugs are very similar to cetirizine? |
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Definition
| loratadine and fexofenadine |
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|
Term
|
Definition
|
|
Term
|
Definition
|
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Term
|
Definition
| 5-HT1b/1d partial agonist |
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|
Term
| 5-HT1b/1d partial agonist - NAME THE DRUG |
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Definition
|
|
Term
|
Definition
| effects not fully understood, may reduce release of calcitonin gene-related peptide and perivascular edema in cerebral circulation |
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|
Term
| effects not fully understood, may reduce release of calcitonin gene-related peptide and perivascular edema in cerebral circulation -- NAME THE DRUG |
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Definition
|
|
Term
| sumatriptan - applications? |
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Definition
|
|
Term
| What to use for migraine and cluster HA? |
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Definition
|
|
Term
| Duration of sumatriptan? Tox? |
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Definition
| duration 2 hrs, tox- paresthesias, dizziness, coronary vasocontriction (additive with others) |
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|
Term
| duration 2 hrs, tox- paresthesias, dizziness, coronary vasocontriction (additive with others) - NAME THE DRUG |
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Definition
|
|
Term
| How do other triptans differ from sumatriptan? |
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Definition
|
|
Term
|
Definition
| tegaserod (for IBS, constipation) |
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|
Term
|
Definition
| H4 agonist (for IBS, constipation) |
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|
Term
| Serotonin agonists work at which receptors? What about antagonists? |
|
Definition
| agonists: 5-HT1b/1d, 5-HT4. Antagonists: 5-HT2, 5-HT3 |
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|
Term
|
Definition
| ketanserin (not available in USA) |
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|
Term
|
Definition
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|
Term
|
Definition
| prevents vasoconstriction and bronchospasm of carcinoid syndrome |
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|
Term
| prevents vasoconstriction and bronchospasm of carcinoid syndrome - NAME THE DRUG |
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Definition
|
|
Term
| ketanserin - applications? |
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Definition
| HTN, carcinoid syndrome assoc with carcinoid tumor |
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|
Term
| for HTN, carcinoid syndrome assoc with carcinoid tumor - NAME THE DRUG |
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Definition
|
|
Term
|
Definition
|
|
Term
| tox: hypotension - NAME THE DRUG |
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Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| ergotamine, ergonovine, and LSD are... |
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Definition
|
|
Term
|
Definition
| ergotamine, ergonovine, and LSD |
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|
Term
|
Definition
| a vasoselective ergot alkaloid |
|
|
Term
| name a vasoselective ergot alkaloid |
|
Definition
|
|
Term
|
Definition
| mixed partial agonist at 5-HT2 and alpha receptors |
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|
Term
| mixed partial agonist at 5-HT2 and alpha receptors - name the drugs |
|
Definition
| ergotamine and ergonovine |
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|
Term
|
Definition
| causes marked smooth muscle contraction but blocks alpha-agonist vasocontriction |
|
|
Term
| causes marked smooth muscle contraction but blocks alpha-agonist vasocontriction -- NAME THE DRUG |
|
Definition
|
|
Term
| ergotamine - applications? |
|
Definition
| migraine and cluster headache |
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|
Term
| besides sumatriptan, what can be used for migraine and cluster HA? |
|
Definition
|
|
Term
|
Definition
| prolonged vasospasm causing gangrene, uterine spasm |
|
|
Term
| tox: prolonged vasospasm causing gangrene, uterine spasm - NAME THE DRUGS |
|
Definition
| ergotamine and ergonovine |
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|
Term
|
Definition
| uteroselective ergot alkaloid |
|
|
Term
| name a uteroselective ergot alkaloid |
|
Definition
|
|
Term
|
Definition
| mixed partial agonist at 5-HT2 and alpha receptors |
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|
Term
|
Definition
| marked smooth muscle contraction, some selectivity for uterine smooth muscle, blocks alpha-agonist vasoconstriction |
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|
Term
| marked smooth muscle contraction, some selectivity for uterine smooth muscle, blocks alpha-agonist vasoconstriction - NAME THE DRUG |
|
Definition
|
|
Term
| ergonovine - clinical applications? |
|
Definition
| postpartum bleeding, migraine |
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|
Term
| for postpartum bleeding, migraine - NAME THE DRUG |
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Definition
|
|
Term
| methylergonovine can be given... |
|
Definition
|
|
Term
| duration of ergotamine? ergonovine? |
|
Definition
|
|
Term
|
Definition
| lysergic acid diethylamide - a CNS selective ergot alkaloid |
|
|
Term
| name a CNS-selective ergot alkaloid |
|
Definition
|
|
Term
|
Definition
| CNS 5-HT2 and dopamine agonist, peripheral 5-HT2 agonist |
|
|
Term
| CNS 5-HT2 and dopamine agonist, peripheral 5-HT2 agonist -- NAME THE DRUG |
|
Definition
|
|
Term
|
Definition
| hallucinations, psychotomimetic |
|
|
Term
| hallucinations, psychotomimetic - NAME THE DRUG |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| several hours, prolonged psychotic state, flashbacks |
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|
Term
| Distribution of histamine receptors H1, H2, and H3 |
|
Definition
| Smooth muscle; stomach, heart, and mast cells; nerve endings, CNS respectively |
|
|
Term
| Prototype antagonist of H1 and H2 receptors |
|
Definition
| Diphenhydramine and impromidine respectively |
|
|
Term
| 1st generation antihistamine that is least sedating |
|
Definition
| Chlorpheniramine or cyclizine |
|
|
Term
| Generation of antihistamine that has the most CNS effects |
|
Definition
| First generation due to being more lipid-soluble |
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|
Term
| Antihistamine that can be used for anxiety and insomnia and is not addictive |
|
Definition
|
|
Term
| H1 antagonist used in motion sickness |
|
Definition
| Dimenhydrinate, meclizine, and other 1st generation |
|
|
Term
| H2 blocker that causes the most interactions with other drugs |
|
Definition
|
|
Term
| Clinical use for H2 blockers |
|
Definition
| Acid reflux disease, duodenal ulcer and peptic ulcer disease |
|
|
Term
| Receptors for serotonin (5HT-1) are located |
|
Definition
| Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance |
|
|
Term
| Triptan available in parenteral and nasal formulation |
|
Definition
|
|
Term
| H1 blocker that is also a serotonin antagonist |
|
Definition
|
|
Term
| 5HT2 antagonist mediate synaptic excitation in the CNS and smooth muscle contraction |
|
Definition
| Ketanserin, cyproheptadine, and ergot alkaloids (partial agonist of alpha and serotonin receptors) |
|
|
Term
| Agents used in treatment of carcinoid tumor |
|
Definition
| Ketanserin cyproheptadine, and phenoxybenzamine |
|
|
Term
5HT-3 antagonist used in chemotherapeutic induced
emesis |
|
Definition
Ondansetron, granisetron,
dolasetron and alosetron |
|
|
Term
| Drug used in ergot alkaloids overdose, ischemia and gangrene |
|
Definition
|
|
Term
| Reason ergot alkaloids are contraindicated in pregnancy |
|
Definition
|
|
Term
|
Definition
| Hallucinations resembling psychosis |
|
|
Term
| Peptide causing increased capillary permeability and edema |
|
Definition
|
|
