Term
|
Definition
| Irreversibly blocks a1 (>) and a2, indirect baroreflex activation |
|
|
Term
| Phenoxybenzamine - effects? |
|
Definition
|
|
Term
| Phenoxybenzamine - clinical applications? |
|
Definition
| pheochromocytoma, high catecholamine states |
|
|
Term
| Phenoxybenzamine - kinetics, tox? |
|
Definition
| irreversible blocker, half life >1 day, tox - orthostatic hypotension, tachy, MI |
|
|
Term
| What is phentolamine and what is it used for? |
|
Definition
| a1 and a2 antagonist, half life of 45 min after IV injection, used to treat pheochromocytoma |
|
|
Term
|
Definition
| slightly selective for a1a receptors, a-blocker |
|
|
Term
|
Definition
| may relax prostatic smooth muscles more than vascular smooth muscle |
|
|
Term
| Tamulosin - clinical applications? |
|
Definition
|
|
Term
|
Definition
| orthostatic hypotension may be less with this subtype |
|
|
Term
| What are the nonselective B blockers? |
|
Definition
| propanolol, nadolol, timolol |
|
|
Term
| Which drugs have B > a1 block? |
|
Definition
|
|
Term
|
Definition
| blocks a2, elicits increased CNS sympathetic activity, increased norepi release |
|
|
Term
| Which B blockers have partial agonist activity? |
|
Definition
| pindolol, acebutolol, carteolol, bopindolol, oxprenolol, celiprolol, penbutolol |
|
|
Term
| Esmolol - B1 or B2, or both? |
|
Definition
|
|
Term
| What is metyrosine and what is it used for? |
|
Definition
| blocks tyrosine hydroxylase and reduces synthesis of dopamine, norepi and epi. Pheochromocytoma |
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