Term
| Three Classes antianginal drugs |
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Definition
Organic nitrates
Beta-adrenergic antagonists
Calcium Channel Blockers |
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Term
|
Definition
| First to describe Angina pectoris |
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Term
|
Definition
| Introduced sublingual nitroglycerin, lasts 20-30min |
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Term
|
Definition
| Introduced amyl nitrite by inhalation, lasts 3-5min |
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Term
|
Definition
Due to lipid deposits in coronary arteries
Pain from diminished oxygen supply |
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Term
| Four 'E's precipitating Angina |
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Definition
Eating
Exercise
Excitement
Exposure |
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Term
| Mechanism of Action of Organic Nitrates |
|
Definition
Vasodilation of large veins
Dilate large coronary arteries |
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Term
|
Definition
| Converted in nitric oxide and into smooth muscle results in relaxation of blood vessel |
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Term
| Enzyme nitric oxide synthase |
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Definition
| Converts arginine into citrulline and nitric oxide |
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Term
|
Definition
| Absorbed into blood vessels quickly under tongue, effects 20-30min |
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Term
|
Definition
Slow onset (1 hour) but long duration
Rubbed onto skin |
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Term
|
Definition
| Long lasting but tolerance develops |
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Term
|
Definition
| Termination individual attack, prevention individual attack and chronic prophylaxis |
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Term
| Beta-Adrenergic Blocking Agents |
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Definition
| Block beta receptors in heart decreasing heart rate and myocardial contractility, cardiac output and myocardial oxygen requirements decrease |
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Term
|
Definition
Beta-adrenergic blocking drug
Decreases frequency of anginal attacks |
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Term
| Nifedipine (Calcium Blocker) |
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Definition
| Prevents sequence of events leading to constriction of arterioles, vascular smooth muscle remains dialate |
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Term
| Cardiac glycosides (digitalis) |
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Definition
| Binds to sodium, potassiume-ATPase and inhibits extrusion of sodium from cardiac cells, increase calcium, greater force of contraction |
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Term
| Therapeutic Uses of Digitalis |
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Definition
| Congestive heart failure, treatment disordered electrical rhythms of heart (arrhythmia) |
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Term
| Adverse effects of digitalis |
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Definition
| Nausea and vomiting, arrhythmia, blurred vision, headache, fatigue, muscle weakness, confusion |
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