Term
| MOA of Penicillins (PCNs) |
|
Definition
Beta-lactams that inhibit bacterial cell wall synthesis by binding to one or more pencillin-binding proteins (PBPs) thus inhibiting final step in bacterial cell wall synthesis. |
|
|
Term
| Concentration dependent or time dependent? |
|
Definition
|
|
Term
| Brand name for Amoxicillin |
|
Definition
|
|
Term
| Brand name for Amoxicillin + Clavulanate |
|
Definition
|
|
Term
| What does the clavulanate do? |
|
Definition
Used to combat antibiotic resistance. Certain bacteria secret beta-lactamase which inactivates penicillins.
|
|
|
Term
| Amoxicillin is mostly active against what? |
|
Definition
Gram positive cocci (staph and strep) and some gram negative.
no atypical coverage.
|
|
|
Term
| Amoxicillin is the DOC for what? |
|
Definition
acute otitis media
H pylori regimen
pregnancy
prophylaxis for endocarditis |
|
|
Term
| Name two possible serious side effects? |
|
Definition
Agranulocytosis (severly lowered white blood cell count)
Increased LFTs |
|
|
Term
| Pregnancy category of Amoxicillin |
|
Definition
|
|
Term
| Brand name for Ampicillin |
|
Definition
|
|
Term
| Brand name for Ampicillin + sulbactam |
|
Definition
|
|
Term
| Brand name for Penicillin |
|
Definition
|
|
Term
| Brand name for Piperacillin + tazobactam |
|
Definition
|
|
Term
|
Definition
Used to combat bacteria that secrete beta-lactamase that would otherwise render pipericilling inactive.
|
|
|
Term
| What does the sulbactam do? |
|
Definition
Beta-lactamase inhibitor. Used to combat bacteria that secrete beta-lactamases that would otherwise render ampicillin inactive.
|
|
|
Term
| Should Augmentin be refrigerated or not? |
|
Definition
| Yes. Must be refrigerated. |
|
|
Term
| Should Amoxil oral suspension be refrigerated or not? |
|
Definition
| May be refrigerated to improve taste. |
|
|
Term
| When should Moxatag be taken? |
|
Definition
| Within one hour of finishing a meal. |
|
|
Term
| Should Pen VK be refrigerated or not? |
|
Definition
| Yes. Must be refrigerated. |
|
|
Term
|
Definition
|
|
Term
| Reduce dose in renal impairment for all PCNs except for? |
|
Definition
|
|
Term
| Brand name for Ticarcillin + clavulanic acid? |
|
Definition
|
|
Term
| Brand name for Ticarcillin? |
|
Definition
None. It isn't formulated by istself. Always formulated with clavulanic acid. |
|
|
Term
| Uricosuric agents such as probenecid and allopurinol do what to the levels of PCNs? |
|
Definition
Increase
Note: uricosuric = increase urine acid excretion |
|
|
Term
| PCNs may do what to oral contraceptives? |
|
Definition
| Decrease effectiveness of oral contraceptives - check package insert for individual drug. |
|
|
