Term
| Increasing the bulkiness of the substituents on the N-atom on catecholamines: |
|
Definition
| Makes the drug a better B-agonist |
|
|
Term
| If a drug is not susceptible to uptake 1 or MAO, it will likely have: |
|
Definition
| A longer duration of action |
|
|
Term
| Removal of one or both hydroxyl groups on catecholamines (Epi, NE, etc): |
|
Definition
| Abolishes affinity for receptors |
|
|
Term
| Hydroxyl groups on catecholamines are: |
|
Definition
|
|
Term
| Modification of the benzene ring in catecholamines: |
|
Definition
| Makes better B-antagonists |
|
|
Term
|
Definition
| Mimic the actions of Epi and NE |
|
|
Term
| Using this type of drug can cause adverse events in patients with HTN and asthma. |
|
Definition
| Non-selective beta blockers |
|
|
Term
| This type of sympathomimetic drug mechanism of action mimics noradrenergic effects by binding to adrenoreceptors. |
|
Definition
|
|
Term
| This type of sympathomimetic drug mechanism of action may either facilitate neurotransmitter release OR block neuronal reuptake. |
|
Definition
|
|
Term
| Indirect enzyme inhibitors, like MAOIs and tyramine are factors that: |
|
Definition
| Enhance adrenergic effects |
|
|
Term
|
Definition
| alpha-1 selective agonist |
|
|
Term
|
Definition
| alpha-1 selective agonist |
|
|
Term
|
Definition
| alpha-2 selective agonist |
|
|
Term
|
Definition
| Non-selective beta agonist |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Phenylephrine is used clinically for: |
|
Definition
| Nasal congestion, pupil dilation, arrhythmia |
|
|
Term
| Methoxamine is used clinically for: |
|
Definition
| Treating hypertension during surgery |
|
|
Term
| Clonidine is used clinically to treat: |
|
Definition
|
|
Term
| Isoproterenol is used clnically as: |
|
Definition
|
|
Term
| Dobutamine is used clinically to treat: |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Adrenergic receptor agonists cause these actions on the cardiovascular system: |
|
Definition
| Increased heart rate (Chronotropic effects), increase contractility (Inotropic effects), and compensatory reflexes |
|
|
Term
| An example of compensatory reflexes would be: |
|
Definition
| Drugs that cause vasoconstriction cause reflex slowing of the heart |
|
|
Term
| Alpha-1 agonists will cause this in vascular smooth muscle: |
|
Definition
|
|
Term
| Alpha-1 agonists increase or decrease arterial resistance? |
|
Definition
|
|
Term
| Alpha-1 agonists cause increase or decrease in BP? |
|
Definition
|
|
Term
| Beta-2 agonists cause this in vascular smooth muscle: |
|
Definition
|
|
Term
| Beta-2 agonists cause increase or decrease in arterial resistance? |
|
Definition
|
|
Term
| Beta-2 agonists cause increased or decreased BP? |
|
Definition
|
|
Term
| Control of BP is mediated by: |
|
Definition
| Baroreceptors in the aortic arch and carotid sinus |
|
|
Term
| Epinephrine has this effect on the heart: |
|
Definition
| Increases contractility and heart rate |
|
|
Term
| Beta-1 receptors on myocardial cells cause: |
|
Definition
| Increase in contractility |
|
|
Term
| Beta-1 receptors in the pacemaker cells of the SA node cause: |
|
Definition
|
|
Term
| Adrenergic activation of beta-2 receptors causes: |
|
Definition
|
|
Term
| Adrenergic activation of alpha-1 receptors causes: |
|
Definition
|
|
Term
| Bronchodilation is caused by activation of these receptors: |
|
Definition
|
|
Term
| Decreased gastrointestinal contractions are caused by activation of this receptor: |
|
Definition
|
|
Term
| Relaxation of the detrusor muscle of the urinary bladder is caused by activation of this receptor: |
|
Definition
|
|
Term
| Contraction of the sphincter muscle of the urinary bladder is caused by the activation of this type of receptor: |
|
Definition
|
|
Term
| Contraction of the radial dilator muscle of the iris is caused by activation of this type of receptor: |
|
Definition
|
|
Term
| Inhibition of insulin secretion from insulin-secreting beta-cells is caused by: |
|
Definition
| Activation of alpha-2 receptors |
|
|
Term
| Glucagon secretion from glucagon-secreting alpha-cells is caused by: |
|
Definition
| Activation of beta-2 receptors |
|
|
Term
| Gluconeogenesis and glycogenolysis in the liver are caused by: |
|
Definition
| Activation of beta-2 receptors |
|
|
Term
| Lipolysis in adipocytes is caused by: |
|
Definition
| Activation of beta-3 receptors |
|
|
Term
| This causes increased circulating glucose, lactic acid, free fatty acids: |
|
Definition
|
|
Term
| In summary, sympathetic effects on metabolism causes: |
|
Definition
| Increase blood glucose and lipid levels, decrease insulin levels, increase glucagon levels |
|
|
Term
| This drug can be used to treat severe allergic reactions, including anaphylaxis: |
|
Definition
|
|
Term
| This drug can be used to treat cardiac arrest and bradycardia: |
|
Definition
|
|
Term
| This drug can be used to prevent surgical bleeding along a surgical incision: |
|
Definition
|
|
Term
| This drug can be used to prevent surgical bleeding along a surgical incision: |
|
Definition
|
|
Term
| This drug is used to treat acute hypotension and cardiogenic shock: |
|
Definition
|
|
Term
| This drug is clinically used to treat septic shock: |
|
Definition
|
|
Term
| This drug is clinically used to treat upper GI bleeding: |
|
Definition
|
|
Term
| Phenylephrine is_______ for ______ receptors. |
|
Definition
|
|
Term
| Phenylephrine is an alpha-1 ________. |
|
Definition
|
|
Term
| Phenylephrine is clinically used to treat: |
|
Definition
| Nasal and sinus congestion |
|
|
Term
| Phenylephrine has this effect on the eyes: |
|
Definition
|
|
Term
| Phenylephrine is used to treat these cardiovascular events: |
|
Definition
|
|
Term
| Phenylephrine causes this in vascular smooth muscle tissue: |
|
Definition
|
|
Term
| Clonidine is ______ for _______ receptors. |
|
Definition
|
|
Term
| Clonidine is a selective alpha-2 _____. |
|
Definition
|
|
Term
|
Definition
| Hypotension, bradycardia, and sedation |
|
|
Term
| Clonidine is clinically used to treat this cardiovascular disease: |
|
Definition
|
|
Term
| Dobutamine is a ______ _______. |
|
Definition
| Selective; beta-1 agonist |
|
|
Term
| Dobutamine causes these effects on the heart: |
|
Definition
| Increase heart rate, increase contractility |
|
|
Term
| Dobutamine is clinically used to treat: |
|
Definition
| Congestive heart failure, cardiogenic shock, septic shock |
|
|
Term
| Albuterol and terbutaline affect this receptor: |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Albuterol and terbutaline are clinically used to treat: |
|
Definition
|
|
Term
| Albuterol can be used to treat this electrolyte imbalance: |
|
Definition
|
|
Term
| Terbutaline is clinically used during pregnancy to: |
|
Definition
| Inhibit uterine contractions in premature labor |
|
|
Term
| Eating wine and cheese while taking an MAOI causes an adverse event due to the interaction of the MAOI and this molecule: |
|
Definition
|
|
Term
| Tyramine-MAOI adverse events cause: |
|
Definition
|
|
Term
| Why does ephedrine cause side effects? |
|
Definition
| It is lipid soluble --- crosses the BBB |
|
|
Term
| Ephedrine stimulates the release of: |
|
Definition
|
|
Term
| Why does ephedrine have a long duration of action? |
|
Definition
| It is not a substrate for COMT or MAO |
|
|
Term
| Ephedrine is clinically used to treat: |
|
Definition
| Asthma, orthostatic hypotension, nasal congestion,and depression |
|
|
Term
| Pseudoephedrine is clinically used to treat: |
|
Definition
|
|
Term
| Pseudoephedrine indirectly stimulates the release of: |
|
Definition
|
|
Term
| Pseudoephedrine acts directly on ____ receptors, and to a lesser extent ____ receptors. |
|
Definition
|
|
Term
| Phenylpropanolamine is clinically used to treat: |
|
Definition
|
|
Term
| Phenylpropanolamine indirectly stimulates the release of: |
|
Definition
|
|
Term
| Phenylpropanolamine acts directly on ____ receptors, and to a lesser extent on _____ receptors. |
|
Definition
|
|
Term
| What is the mechanism of action of amphetamine? |
|
Definition
| Stimulates the release of NE and blocks uptake 1. |
|
|
Term
| Amphetamine causes a euphoric experience because: |
|
Definition
| It crosses the BBB and stimulates the release of dopamine |
|
|
Term
| Amphetamine is clinically used to treat: |
|
Definition
| ADHD, narcolepsy, and obesity |
|
|
Term
| Cocaine is clinically used as: |
|
Definition
| A local anesthetic; opthalmic anasthetic |
|
|
Term
|
Definition
|
|
Term
| Cocaine stimulates the release and _____ of norepinephrine. |
|
Definition
|
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