Term
| What can cause systolic CHF? |
|
Definition
|
|
Term
| What type of CHF requires drug therapy? |
|
Definition
|
|
Term
Dopamine.
Dobutamine
Beta Blockers
Pre/After |
|
Definition
|
|
Term
ACE
Calcium Channel
AT-2
Organic Nitrates
Vasodilators
Alpha 1 block (prazosin)
Diuretics
Nesiritide
Pre/After |
|
Definition
ACE- Both
Calcium Channel- After
AT-2-Both
Organic Nitrates-After
Vasodilators-Both
Alpha 1 block (prazosin)After
Diuretics-Pre
Nesiritide-Both |
|
|
Term
|
Definition
diuretics
ACE
Beta Block
Vasodilators
Glycosides
Nesiritide
Inotropes |
|
|
Term
| Effects of atropine in heart: |
|
Definition
Block ACH
NE LIke
Increase automaticity/CV |
|
|
Term
| In diseased patients what normally happens to ERP and CV |
|
Definition
CV is usually slowed
ERP is usually shortened |
|
|
Term
| Which type 1A drug causes less HOTN? |
|
Definition
|
|
Term
| Which type of anti-arrythmic do you often need to give an anti-coagulant with? Why? |
|
Definition
| Often need to give with 1A drugs (quinidine) bc increase risk of emboli |
|
|
Term
| Which anti-arrythmic has "pro-arrythmic effects" and can be fatal. Name/Class |
|
Definition
|
|
Term
| What are the mediators in autoregulation? |
|
Definition
|
|
Term
| Type of angina nitrates are used to treat? |
|
Definition
|
|
Term
| How do nitrates work? (primary/secondary effects) |
|
Definition
1*preload reduction (decresaed demand)
2* Coronary artery dilation @ ischemic tissues--shunt O2 to ischemic
3*afterload reduction (decreased work) |
|
|
Term
| What are some systemic effects of organic nitrates? |
|
Definition
| HOTN (can cause baro-receptor release) |
|
|
Term
| Side effects of nitrates: |
|
Definition
| headache, HOTN, methemoglobinemia |
|
|
Term
| How does tolerance to nitrates develop? |
|
Definition
Depletion of cysteine and SH groups
Down regulation of ADH activity |
|
|
Term
|
Definition
Formation of S-nitrothiols from cysteine
ADH forms NO
Guanylate cyclase is stimulated by S-nitrothiols and NO
This produces cGMP and increases CAMP |
|
|
Term
| What type of angina are beta blockers used for treating?? |
|
Definition
|
|
Term
| Type of angina Calcium channel blockers are used for |
|
Definition
Stable and Variant
Stable: verapamil
Variant: dihydropyridines |
|
|
Term
| Selectivity of tissues of calcium channel blockers: |
|
Definition
Verapamil: AV>>Myo>>SM
Diltiazem:SM>>Myo>>AV
Nifedipine:SM>>Myo |
|
|
Term
| What is the MOA of ranolazine: primary and secondary |
|
Definition
Blockade of late sodium channels (fix the impaired na/ca exchanger from ischemia)
pFOX inhibitor (lipid metabolism of the heart for energy, decreases metabolic rate and thus O2 demand |
|
|
