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Definition
| ability of material to pull moisture in (aka dry powder+heat = wet) |
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Term
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Definition
substances (mostly salts) that have a strong affinity for moisture and will absorb large amounts of water from atmosphere, forming liquid solution
-used in industry to remove water produced by chemical reactions |
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Definition
| the pH where the drug is equally ionized and unionized (50% ionized, 50% unionized) |
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Term
| if the drug is a weak acid, and the solution is more acidic, ionized or unionized? |
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Definition
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Term
| if drug is weak acid and the pH of the solution is more basic, is it ionized or unionized? |
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Definition
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Term
| if the drug is a weak base, and the pH is more acidic, is the drug ionized or unionized? |
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Definition
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Term
| if the drug is a weak base and the pH of the solution is more basic, is it unionized or ionized? |
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Definition
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Term
| if you want a weak acid-drug in solution, what kind do u choose? |
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Definition
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Term
| if you want a weak base-drug in solution, which solution do u choose?a |
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Definition
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Term
| if you have a weak acid (drug) at Cs and lower the pH of the solution, what happens? |
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Definition
| solution becomes supersaturated, the drug ppts out until saturation is restored |
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Term
| example of a weakly acidic drug |
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Definition
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Term
| example of weakly basic drug |
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Definition
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Term
| solubility of zwitterions? |
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Definition
| electronically neutral, so insoluble |
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Term
| fast rate of crystallization = which solid state? |
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Definition
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Term
| what is the Nernst equation for crystalization? |
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Definition
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Term
| which has higher potential energy (crystal or amporphous) and what effect does that have |
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Definition
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Term
| what is the solid state of semilente? |
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Definition
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Term
| what is the solid state of ultralente? |
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Definition
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Term
| what is the solid state of lente? |
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Definition
| 30% amorphous and 70% crystal |
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Term
| what happens if you drive the solvent of crystallization out of an inclusion body? |
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Definition
| there is no change in the polymophic form of the crystal bc the solven was never part of the structure of the crystal lattice |
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Term
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Definition
| freeze drying; when you drop the pressure to freeze the water/drug; then drop the pressure via vacuum to evaporate water via sublimation so drug is a solid form (powder). drug started as liq: now a solid |
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Term
| If the Triple point is below atmospheric pressure, compound will: |
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Definition
| melt from solid to liquid to gas |
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Term
| if triple point is above atmospheric pressure, compound will: |
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Definition
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Term
| why lyophilize drugs? (2 reasons) |
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Definition
1 aqueous instability (hydrolysis)
2 heat labile |
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Term
| why can't you heat drug compound to lyophilize? |
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Definition
| sensitive to heat-must drop pressure |
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Term
| how do you prevent eutection? |
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Definition
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Term
| diluting a cosolvent system does what? |
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Definition
| supersaturation>>>precipitates out |
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Term
| increasing temp of saturated solution does what? |
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Definition
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Term
| decreasing temp of solution does what |
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Definition
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Term
| Federal Food, Drug, and Cosmetic Act |
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Definition
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Term
| Durham Humphrey Amendment |
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Definition
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Term
| Kefauver-Harris Amendment |
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Definition
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Term
| Drug Price Competition and Patent Term Restoration Act |
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Definition
| established modern system of generic drugs |
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Term
| hat year was antisubstitution legislation repealed? |
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Definition
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Term
| bioequivalency codes in orange book are updated.... |
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Definition
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Term
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Definition
| adding an impurity to a pure substance will cause the substance to melt at a lower temp |
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Term
| example of functional claim: |
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Definition
| will provide a peaceful sleep |
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Term
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Definition
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| which polymorph of insulin is the smallest |
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Definition
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Term
| which insulin is largest? |
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Definition
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