Term
| In Males, LH stimulates the _______ cells which produce ________, thereby inhibiting the _________ |
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Definition
| Leydig Cells; testosterone; hypothalamus |
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Term
| In males, FSH stimulates the ______ to produce ______ which inhibits the __________ |
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Definition
| Sertoli Cells; inhibin; anterior pituitary |
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Term
| Spermatogenesis is controlled by both ______ and _______ acting via the _________ cells |
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Definition
| FSH; Testosterone; Sertoli |
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Term
| Where is testosterone produced? |
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Definition
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Term
| What are the actions of androgens? |
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Definition
Reproductive tract and external genitalia Sexual differentiation in utero (first trimester) Maturation at puberty Maintenance in adult (tract only) |
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Term
| Name three secondary sexual characteristics present at the onset of puberty |
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Definition
Male pattern of hair growth Deeper voice Increased Muscle Growth |
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Term
| Nonreproductive effects of androgens |
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Definition
Anabolic actions - Muscle and bone Pubertal growth spurt then closure of epiphyses (end portion of long bones where growth occurs) Increased secretion by sebaceous glands |
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Term
| Name the differences between Testosterone, DHT, and Estradiol |
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Definition
DHT - Responsible for hair (baldness), spermatogenesis, and male reproductive tract Testosterone - Responsible for Muscle, Negative feedback on Hypothalamus, Spermatogenesis, Libido Estradiol - Bone Mass |
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Term
| Ways in which target tissue can be insensitive to testosterone |
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Definition
1 5alpha-Reductase Deficiency 2. Testicular Feminization - Absence of androgen receptors |
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Term
| Hypergonadism (Rare in adults) |
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Definition
1. Precocious puberty -> Increase GnRH secretion -> premature sexual development 2. Pseudoprecocious puberty -> Ectopic LH (tumor) or adrenal androgen (congenital andrenal hyperplasia) secretion. |
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Term
| In what ways can you have hypogonadism? |
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Definition
1. Postpubertal -> decrease fertility, decrease strength, more likely to develop osteoporosis 2. 5alpha-Reductase deficiency 3. Androgen Receptor Defect |
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Term
| Information about Hypergonadism in males |
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Definition
1. Very rare in adults 2. In children, this is precocious puberty 3. Can be caused by prostate disease 4. Can be caused by cancer, more specifically by Benign Prostatic Hyperplasia. |
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