Term
| In which disease are Heinz bodies and Bite cells seen? |
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Definition
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Term
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Definition
| Precipitates of denatured globin in red cells |
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Term
| What stain you can do to look for Heinz bodies ? |
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Definition
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Term
| Two types of microcytic anemias ? |
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Definition
Iron deficiency anemia
Thalassemias |
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Term
| Only hemolytic anemia due to acquired mutation in myeloid stem cells (mutation in PIGA gene) ? |
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Definition
| PNH (Paroxysmal Nocturnal Hemoglobinuria) |
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Term
| In PNH, mutation in PIGA leads to absence of CD55, CD59, and C8 binding proteins, and this causes ? |
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Definition
| Complement mediated hemolysis of RBCs |
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Term
| Flaer test can diagnose what ? |
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Definition
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Term
| Intravascular hemolysis and venous thrombosis are complications of what ? |
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Definition
PNH
Thrombosis is leading cause of death |
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Term
| You see schistocytes (fragmented RBCs) in what type of anemia ? |
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Definition
Microangiopathic hemolytic anemia
Where RBCs are mechanically damaged by passing through obstructed blood vessels
This anemia also can be seen in conditions like DIC, malignant hypertension, SLE, TTP, and disseminated cancer |
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Term
| Most common anemia in hospitalized patients ? |
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Definition
Anemia of chronic disease
Increase IL-6 causes increase in hepcidin |
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Term
| Biochemical indicators of anemia of chronic disease ? |
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Definition
Increase serum ferritin, increase bone marrow iron
Decrease serum Fe and decrease TIBC
Decrease EPO (erythropoietin levels) |
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Term
| 2 causes of megaloblastic anemias ? |
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Definition
Folate deficiency or Vit B12 (cobalmin) deficiency
Both needed for synthesis of thymidine base which is needed for DNA synthesis, leads to nuclear/cytoplasmic asynchrony |
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Term
| One big clinical difference in folate vs. Vitamin B12 deficiency that can be seen in megaloblastic anemia ? |
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Definition
| Vitamin B12 deficiency gives rise to neurological abnormalities (demyelinating disorder of peripheral nerves and spinal cord) |
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Term
| 3 clinical symptoms found in all anemias ? |
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Definition
| Pallor, fatigue, lassitude |
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Term
| Mechanism of pernicious anemia ? |
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Definition
Atrophic gastritis -> IF not produced -> Vitamin B12 not absorbed -> megaloblastic anemia
Most common in North Europeans
Insidious onset |
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Term
| Immunophenotype markers for Hairy cell leukemia ? |
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Definition
| CD11c, CD20, CD25, CD103+ |
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Term
| Specific stain for Hairy cell leukemia ? |
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Definition
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Term
| Immunophenotype markers for SLL / CLL (Chronic Lymphocytic Leukemia) ? |
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Definition
| CD5 CD19 CD20 CD23 CD43 positive |
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Term
| Immunophenotype markers fro Burkitt's Lymphoma ? |
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Definition
| CD10 CD19 CD20 Surface Ig |
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Term
| Characteristic translocation and immunophenotype markers for Follicular Lymphoma ? |
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Definition
t(14;18) translocation
CD10+ CD19 CD20 BCL6 |
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Term
| 90% of NHLs (Non-Hodgkin's Lymphomas) are ? |
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Definition
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Term
| Reed-Sternberg cells are characteristic of what lymphoma ? |
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Definition
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