Term
| What is the best type of repair? |
|
Definition
Resolution
is the best type of repair. It entails removal of tissue debris and inflammatory cells, drainage of fluid, and probably mild proliferation of the intact parenchymal cells (e.g., healing of lobar pneumonia). |
|
|
Term
| What do you call repair by fibrous tissue or scarring? |
|
Definition
|
|
Term
| What do you call repair by the same type of cells as those destroyed? E.g. repair by proliferation of hepatocytes after liver cells injury |
|
Definition
|
|
Term
| What growth factor is present in secretions and fluids? |
|
Definition
| EGF (Epidermal Growth Factor) |
|
|
Term
| What growth factor is present within platelet alpha granules, macrophages, endothelial cells, smooth muscle cells and some tumor cells? |
|
Definition
| PDGF (Platelet Derived Growth Factor) |
|
|
Term
| What growth factor helps repair by stimulating fibroblast chemotaxis, and production of collagen and fibronectin? It inhibits collage breakdown by inhibiting proteases. |
|
Definition
| Transitional Growth factor |
|
|
Term
| Which growth factor is confined to neural tissues? |
|
Definition
| (FGFs) Fibroblast Growth Factor |
|
|
Term
| Is an intact ECM (Extracellular matrix) required for tissue regeneration? |
|
Definition
| Yes, otherwise you get scar tissue |
|
|
Term
| Give three examples of labile cells. |
|
Definition
1. Skin
2. Hematopoietic cells
3. Gastrointestinal mucosa |
|
|
Term
| Give three examples of stable cells. |
|
Definition
1. Liver
2. Renal tubular cells
3. Glial cells in the CNS |
|
|
Term
| Give three examples of permanent cells. |
|
Definition
1. Adult neurons
2. Renal glomeruli
3. Retinal epithelial cells |
|
|
Term
| What is the key characteristic of corneal neovascularization as opposed to other conditions? |
|
Definition
| The vessels must cross the limbus |
|
|
Term
| What are five systemic factors that effect wound repair? |
|
Definition
1. Nutrition
2. Vitamin Deficiency
3. Age
4. Immune status
5. Other factors such as diabetes |
|
|
Term
| What are the local factors that effect wound repair? |
|
Definition
1. necrosis
2. apposition
3. infection
4. blood supply
5. mobility
6. foreign body |
|
|
Term
| What are two things that inhibit collagen synthesis? |
|
Definition
| Vitamin C and protein deficiency and corticosteroids |
|
|
Term
| What can talcum powder on a wound do? |
|
Definition
| create a noninfective granuloma and delay healing |
|
|
Term
What happens at the following stages of skin wound healing?
Immediate
24 hours
3-7 days
weeks
months |
|
Definition
Immediate-blood clot fills the wound
24 hours-Inflammation, WBC moves to the site of injury
3-7 days-macrophage activity, granulation tissue, epithelial regeneration
weeks- fibrous vascular union with intact epithelium, mild inflammation
months-no inflammation, remodeling avascular thin scar, minimal contraction |
|
|
