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Definition
| small extensions from an immature neuron that have neither axonal nor dendritic identities yet |
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Definition
| a specialized structure at the tip of the extending axon; explore the extracellular environment, determine the direction of growth, guide the axon in that direction |
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Definition
| a sheetlike expansion of the growing axon at the tip of the growth cone |
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Definition
| regulates changes in the lamellipodial & filopodial shape for directed growth |
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Term
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Definition
| responsible for the elongation of the axon itself |
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Definition
| guide growing axons toward a source |
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Definition
| support the survival & growth of neurons & their processes once an appropriate target has been contacted |
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Definition
| prevent an axon from straying back over the midline once is has crossed initially in response to netrin |
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Term
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Definition
| long-term dependency between neurons and their targets; in the absence of synaptic partners, axons & dendrites of developing neurons typically atrophy & often die |
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Term
| neurotrophic factors/neurotrophins |
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Definition
| signaling molecules provided by target cells that creates the nourishment provided by trophic interactions |
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Term
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Definition
| the highly regulated processes that result in cell death |
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Term
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Definition
| target cells that are supposed to be innervated by a single axon are initially innervated by axons from several neurons |
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Term
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Definition
| inputs to a polyneuronal innervation are gradually lost during early postnatal development until only one remains |
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Term
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Definition
| the number of inputs to a target cell |
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Term
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Definition
| the number of connections made by a neuron |
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Term
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Definition
| neurotrophic protein; elicits robust growth of neuronal processes |
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Term
| 5 well-characterized neurotrophins |
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Definition
1. NGF
2. brain-derived neurotrophic factor (BDNF)
3. neurotrophin-3 (NT-3)
4. neurotrophin-4
5. neurotrophin-5 |
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