Term
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Definition
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Term
| Vancomycin is DOC for what? |
|
Definition
| MRSA infections: 15 mg/kg q8 - 12 hrs |
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Term
| Vancomycin po (oral) is DOC for what? |
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Definition
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Term
| Vancomycin time dependent or concentration dependent killing? |
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Definition
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Term
| What can happen if vancomycin in infused to rapidly? |
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Definition
Red Man Syndrome (maculopapular rash due to a too rapid infusion rate).
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|
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Term
| What is the infusion rate for vancomycin? |
|
Definition
| 3o minutes for each 500mg of drug given. |
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Term
| Are troughs or peaks monitored for vancomycin? |
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Definition
|
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Term
| What are the trough levels for vancomycin? |
|
Definition
pneumonia: 15 - 20 mcg/ml
Otherwise: 10-15 mcg/ml |
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Term
| Does vancomycin require renal adjustment? |
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Definition
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Term
|
Definition
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Term
|
Definition
binds to bacterial 23S ribosomal RNA of the 50s subunit inhibiting bacterial translation and protein synthesis. |
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Term
| Antibiotic activity of linezolid |
|
Definition
Treats MRSA, VRE faecium and sometimes VRE faecalis |
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Term
| Dose adjust linezolid in renal impairment? |
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Definition
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Term
| Storage of linezolid oral suspension |
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Definition
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Term
| Brand name for Quinupristin and Dalfopristin |
|
Definition
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Term
|
Definition
binds to different sites on the 50s bacterial ribosomal subunit inhibiting protein synthesis |
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Term
| Dose adjust synercid in renal impairment |
|
Definition
|
|
Term
| What are the conditions for synercid to be given peripherally? |
|
Definition
| Must be in a volume of 250 ml or greater (D5W only). |
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|
Term
| What is the most common side effect of Synercid? |
|
Definition
Phlebitis (40%)
Phlebitis: swelling of a vein cause by a blood clot. |
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Term
| Brand name for Daptomycin |
|
Definition
|
|
Term
| Antibiotic activity of Daptomycin |
|
Definition
| Treats MRSA, VRE faecium and faecalis |
|
|
Term
| Dose adjust in renal impairment? |
|
Definition
|
|
Term
| Can Cubicin be used to treat pneumonias? |
|
Definition
DO NOT USE to treat pneumonias as it is inactivate by surfactants. |
|
|
Term
| Is Cubicin compatible with D5W? |
|
Definition
| Compatible with NS (not D5W) |
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|
Term
| Brand name for Telavancin |
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Definition
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|
Term
| What other drug is Telavancin related to? |
|
Definition
Vancomycin. Telavancin is a lipoglycopeptide derivative of vancomycin and so its MOA is the same - inhibits bacterial cell wall synthesis. |
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Term
| Antibiotic spectrum of Telavancin |
|
Definition
| Active against MRSA, not VRE strains |
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|
Term
| Black Box Warning for Telavancin |
|
Definition
Fetal risk, obtain pregnancy test prior to starting therapy
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|
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Term
| Most common side effect of Telavancin |
|
Definition
|
|
Term
| Reduce dose of Telavancin in renal impairment? |
|
Definition
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Term
|
Definition
Azactam - IV
Cayston - inhaled for CF |
|
|
Term
|
Definition
| monbactam that inhibits bacterial cell wall synthesis by binding to PCPs |
|
|
Term
| Antibiotic coverage of Aztreonam |
|
Definition
| covers Pseudomonas and many gram (-) |
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|
Term
Can it be used in PCN - allergy pts?
Dose adjust in renal impairment?
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|
Definition
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