Term
| are polyenes water soluble? |
|
Definition
| no, they have poor water solubility |
|
|
Term
|
Definition
| nystatin and amphotericin B |
|
|
Term
| what is the spectrum of amphotericin B? |
|
Definition
| fungicidal/fungistatic; blastomyces, histoplasma, coccidiodes, some candida (dimorphic fungi and aspergillus) |
|
|
Term
| how can the polyenes be given? |
|
Definition
| intrathecally or IV, add sterile water and 5% dextrose |
|
|
Term
| Why should you never mix amphotericin B with electrolytes? |
|
Definition
| they will precipitate out |
|
|
Term
| what are some side effects of amphotericin B? |
|
Definition
| convulsions, phebitis, anemia, hypokalemia |
|
|
Term
| what other names does nystatin go by? |
|
Definition
| mycostatin, panalog, mycolog |
|
|
Term
| what is the spectrum of nystatin? |
|
Definition
| topical infections, candida, malasezzia= this one is for the yeasites! |
|
|
Term
What is the mode of action of the imidizoles/triazoles?
Spectrum? |
|
Definition
cell membrane damage-leakage of intracellular constituents and inhibition of uptake of RNA/DNA, inhibit sterol synthesis
it gets most fungi and some Gm+ cocci |
|
|
Term
| Which antifungal is especially useful for dermatophytes and topical yeast infections? |
|
Definition
|
|
Term
| which antifungal can be given only topically, and is good for nasal aspergillosis? |
|
Definition
|
|
Term
| which antifungal is orally absorbable, relatively non-toxic? |
|
Definition
| ketoconazole/iatroconazole |
|
|
Term
| does ketoconazole/iatroconazole penetrate the CSF? |
|
Definition
|
|
Term
| what type of fungus grows in the crack of Kowalski's ass? |
|
Definition
| idon'tcareagillis, memorizosporum, and kissmyassococcus |
|
|
Term
| between ketoconazole and itatroconazole, which is the more potent one? |
|
Definition
|
|
Term
| what drug is used in cats with crypto? one important advantage is that it's water soluble and it gets into the CSF? (well if that dosn't go against everything we learned so far...) |
|
Definition
|
|
Term
| what drug is used for the cutaneous form of sporotrichosis and has a side effect of hair loss? |
|
Definition
|
|
Term
| How does flucytosine work? |
|
Definition
| based on the conversion of 5FC to 5FU, which is not taken up by fungi, associated with the presence of cytosine deaminase, don't ask me i don't understand i'm just memorizing, and additive with amphotericin B |
|
|
Term
| what is flucytosine used for? |
|
Definition
| this is i think that oral med they give women for yeast infections, so that tell you a lot, ie, it's used for mainly yeasts and can also be used for crypto if in combo with amphotericin B. You also must know that it is given orally and rapidly absorbed from the GI tract, well distributed into the body tissues. |
|
|
Term
| What is griseofulvin used for? This card is designed to make u feel smart :) |
|
Definition
| DERMATOPHYTES~ see, I knew you were smart! |
|
|
Term
| How does griseofulvin work? |
|
Definition
| binds to growing fungus and sticks on it's lipids and affects nucleic acid synthesis by affecting the division of chromatin |
|
|
Term
| Why is griseoufulvin the "knight in shining armor" of the skin? |
|
Definition
| Well, it makes the newly formed keratin resistant to infection, like a coat of armor. |
|
|
Term
| What is the ROA of griseofulvin? |
|
Definition
|
|
Term
| why did the fungus cross the road? |
|
Definition
he wanted to be "among us"
` that was really bad, i know |
|
|
Term
| If a dog had histo, blasto, coccidomycosis, or some aspergillus. What drug would be a good choice? |
|
Definition
|
|
Term
| If there was an ear infection with malazezzia pachydermitis or candida, what would be a good choice? |
|
Definition
|
|
Term
| One time I had ringworm on my hand back in 01' (true story) and the office manager where I worked at a vet clinic gave me a dog topical ointment to put on it and it worked. What was it? |
|
Definition
| clotrimazole (just a story to help you remember that clotrimazole, miconazole, conofite, lotrimin, and vetltrim) all can get dermatophytosis~ but still don't forget our friend griseoufulvin!!! |
|
|
Term
| Does Ketoconazole work well for fusarium or aspergillus? |
|
Definition
| no~ but it is good for yeasts, dimorphic fungi, dermatophytes |
|
|
Term
| what should you use for crytococcus cuz it's underlined in the chart? |
|
Definition
| fluconazole or flucytosine |
|
|
Term
| what should you use for aspergillus cuz it's underlined in the chart? |
|
Definition
|
|
Term
| What are iodides used for? |
|
Definition
|
|
Term
| MOA of Amphotericin B and Nystatin, the Polyenes |
|
Definition
| Combines with ergosterol in cell membrane, disrupts membrane integrity, leaks happen, cytoplasm acidifies and cell dies |
|
|
Term
| MOA of Imidizole drugs (miconazole, clotrimazole, lotrimin, conofite, thiabendazole, tresaderm, ketoconazole) |
|
Definition
| Ergosterol precursors accumulate, lanosterol accumulates and interacts with fungal P450 enzymes (also mammilian P450 which can lead to liver probs. in compromised liver patients with these drugs) and can have a direct membrane effect at higher doses |
|
|
Term
| What are some drugs you could use for crypto in the cat brain? |
|
Definition
| flucytosine, fluconazole, amphoteracin B |
|
|
Term
| What is the only drug listed to be given intrathecally? |
|
Definition
|
|
Term
| Why can't nystain be given systemically? |
|
Definition
|
|
Term
| What can be used for mastitis? |
|
Definition
|
|
Term
| What can be used for equine metritis? |
|
Definition
| miconazole or clotrimazole |
|
|
Term
| What drug is given orally (prefferably with food), then moves around skin on sebum? |
|
Definition
|
|
Term
| What drug is good for a yeast UTI? |
|
Definition
|
|
Term
| What are the only antifungals that don't work by leading to build up of ergosterol precursors? |
|
Definition
| amphotericin B and nystatin |
|
|
Term
| What is the problem with griseofulvin in cats? |
|
Definition
|
|
Term
| What drug is used for glaborus (what the ^&%^^*@#?) skin? |
|
Definition
|
|
Term
| Where does iodide concentrate? |
|
Definition
|
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