Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| M, N agonist; AChE resistant |
|
|
Term
|
Definition
| M agonist; AChE resistant |
|
|
Term
|
Definition
| M agonist; AChE resistant |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Soman (organophosphates e.g. echothiophate) |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Choline transporter block (no Ach synthesis) |
|
|
Term
|
Definition
| Ach transporter block (no Ach packaging) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| N block (competitive = non-depolarizing); competetive block of alpha subunit |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Succinylcholine (prototype) |
|
Definition
| N agonist (non-comp = sustained depol = overstimulation = cholinergic crisis) |
|
|
Term
| Diazepam (centrally-acting) |
|
Definition
| Benzo receptor agonist (↑GABAA); post-synaptic; centrally acting |
|
|
Term
| Baclofen (centrally-acting) |
|
Definition
| GABAB receptor agonist; pre-synaptic; centrally acting |
|
|
Term
|
Definition
| Ca2+ channel block at SR; direct acting |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Phenylephrine (methoxamine, midodrine) |
|
Definition
|
|
Term
| Metaproterenol, Ritodrine, Albuterol (terbutaline, salmeterol) |
|
Definition
|
|
Term
|
Definition
| Unregulated NE release (enters via NE transporter) |
|
|
Term
|
Definition
| Unregulated NE release (lipophilic displacement) |
|
|
Term
| Ephedrine (*mixed action) |
|
Definition
| Unregulated NE release; α1, β1 agonist |
|
|
Term
| Cocaine, TCAs (Desipramine) |
|
Definition
|
|
Term
| Metyrosine (α-methyltyrosine) |
|
Definition
| Tyrosine hydroxylase block (no DOPA/NE synthesis) |
|
|
Term
| Trimethphan, Hexamethonium (mecamylamine) |
|
Definition
| Nicotinic block (at NEURONAL ganglia) |
|
|
Term
|
Definition
| DA transporter block (no NE in secretory granules) |
|
|
Term
|
Definition
| Vesicular fusion block (no NE release; enters via NE transporter) |
|
|
Term
|
Definition
| Indirect α2 agonist (DOPA analog → α-Me-NE → α2) |
|
|
Term
| Clonidine (guanabenz, brimonidine) |
|
Definition
|
|
Term
|
Definition
| α1, α2 block (irreversible) |
|
|
Term
|
Definition
| α1, α2 block (reversible) |
|
|
Term
| Prazosin, Doxazosin, Terazosin |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| β1, β2 block (partial agonist) |
|
|
Term
|
Definition
| β1, β2 block (partial agonist) & α1 block |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Gq → PLC → PIP2 → IP3 + DAG → ↑intracellular Ca |
|
|
Term
|
Definition
| Gi → inhibit adenylyl cyclase → ↓cAMP → ↑K+ conductance → ↓HR & ↓contractility |
|
|
Term
|
Definition
| Gq → PLC → PIP2 → IP3 + DAG → ↑intracellular Ca |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Ligand-gated ion channel: binding 2 ACh → Na+ entry → cellular depolarization |
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|
