Term
| Which nAChR is sensitive to a-Bugarotoxin |
|
Definition
|
|
Term
| This receptor has a very low Ca permeability |
|
Definition
|
|
Term
| This cmpd has been introduced for smoking cessation |
|
Definition
| Varenicline (partial agonist) |
|
|
Term
|
Definition
| depolarization-->fast EPSP-->effect |
|
|
Term
| What effect does high [ ] have ganglionic neurotransmission |
|
Definition
| Blocks it. Due to depol. block and desensitization |
|
|
Term
|
Definition
well absorbed
crosses BBB
metab in liver
excreted by kidney |
|
|
Term
|
Definition
increase HR, BP, contractility
decr BP w/high dose |
|
|
Term
|
Definition
|
|
Term
| Low dose of nicotine on resp system |
|
Definition
| incr. in respiration (chemoreceptors) |
|
|
Term
| Moderate dose of nicotine |
|
Definition
|
|
Term
| Toxic dose of nicotine effect on resp system |
|
Definition
| resp. depression and paralysis |
|
|
Term
|
Definition
stimulant
tremors, ADH release
nausea and vomiting (first exposure) |
|
|
Term
|
Definition
| incr. gastric acid secretion, tone, and motility |
|
|
Term
| Acute nicotine poisoning symptoms |
|
Definition
| nausea, abdomen pain, salivation, headache, dizziness, difficulty in breathing, BP falls, failure respiration-DEATH |
|
|
Term
| Treatment of nicotine poisoning |
|
Definition
gastric lavage
activated charcoal
resp support |
|
|
Term
| Mecamylamine mech of action |
|
Definition
comp antag of ACh
does not stimulate receptor |
|
|
Term
|
Definition
poorly PO
short acting
unchanged excretion in kidney |
|
|
Term
|
Definition
second. amine PO use
crosses BBB
excreted slowly by the kidney |
|
|
Term
| Sympathetic predominates in these 4 organs |
|
Definition
| arterioles, veins, sweat glands, genital tract |
|
|
Term
|
Definition
|
|
Term
| Autonomic hyperreflexia is treated with |
|
Definition
|
|
Term
| Side effects of Gang. blockers |
|
Definition
post. hypotension, anginal pain, Ileu
Trimethaphan causes histamine release. |
|
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