Term
| Does a neuromuscular junction have a high or low safety factor? What about central neurons? |
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Definition
NMJ - high safety factor
Central neuron - low safety factor |
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Term
| What types of synapses are usually excitatory? inhibitory? |
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Definition
Excitatory - axodendritic
Inhibitory - axosomatic |
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Term
| Where are metabotropic synapses usually found? What is their purpose? |
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Definition
They are typically found at modulatory axoaxonic synapses
They gate ion channels indirectly |
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Term
| What are the two types of Glutamate gated receptors in the brain? |
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Definition
| NMDA receptors and non-NMDA (AMPA and kainate) receptors |
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Term
| Non-NMDA receptors are the major postsynaptic players in what type of response? |
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Definition
| Excitatory post-synaptic potential (EPSP) |
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Term
| With regards to permeability, how do NMDA and non-NMDA receptors differ? |
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Definition
| NMDA receptor channels are permeable to Ca2+ |
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Term
| NMDA receptors are blocked by what? |
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Definition
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Term
| NMDA receptors play a direct role in what types of cognitive functioning? |
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Definition
| Associative learning and memory installment and consolidation |
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Term
| How is the Mg2+ removed in NMDA receptors? |
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Definition
| If the rate of stimulation is high, Mg2+ block is relieved by a greater depolarization of the postsynaptic membrane potential and calcium enters the postsynaptic neuron through the NMDA receptors |
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Term
| IPSPs result from the activation of postsynaptic receptors that cause an increase in conductance to which ions? |
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Definition
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Term
| Angelman syndrome is due to a mutation of what receptor? |
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Definition
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Term
| Startle disease is due to a mutation of what receptor? |
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Definition
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