Term
| Fast Excitatory Neurotransmitters |
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Definition
open Na/K/Ca Channels
ACh-> neuromuscular junction
Glutamate-> in CNS |
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Term
| Fast Inhibitory Neurotransmitters |
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Definition
Open Cl channels
GABA-> Brain
Glycine-> Spinal Cord |
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Term
| Receptor Regulation-> Anxiety |
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Definition
| Benzodiazepine- promote GABA channel openings |
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Term
| Receptor Regulation-> Myasthenia Gravis |
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Definition
| Inhibit ACh esterase- promotes ACh action at neuromuscular junction |
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Term
| Receptor Regulation-> Parkinsons |
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Definition
| L-DOPA- increases Dopamine supply for synaptic release |
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Term
| Receptor Regulation-> Depression |
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Definition
| SSRI (Selective Seratonin Uptake Inhibitor) increases neurotransmitter levels at synapse |
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Term
Roles of Voltage-Gated Channels->
Na+
K+
Ca++ |
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Definition
Na+->generate action potential depolarization
K+->induce recovery hyperpolarization in AP
Ca++->initiate synaptic transmitter release and muscle contraction |
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Term
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Definition
| 3 transmembrane subunits, 4 total (1 reentrant loop) |
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Term
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Definition
| autoreceptor feedback-neurotransmitter itself turns off more release (GPCR, 7 transmembrane receptor, suppression of voltage gated channel) |
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Term
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Definition
| G-protein binds to Ca++ channel- reduces conductance |
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Term
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Definition
| 2 stimuli in a short time period=larger response |
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Term
| Temporal Postsynaptic summation |
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Definition
| mathematical summation of stimulus when one is added before the other ends |
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Term
| Spatial Postsynaptic Summation |
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Definition
| Graded potentials arriving at different terminals on the same neuron. Individually would be below threshold, but graded potentials arrive at trigger zone at the same time to create suprathreshold signal |
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Term
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Definition
| 2 excitatory and 1 inhibitory neurons fire- summation petential is below threshold, even though the excitatory potentials would be great enough for threshold |
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Term
Shunting Inhibition
(Silent and Depolarizing IPSP)
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Definition
Silent- Cl- channels open but no flow of ions when at rest. When EPSP arrives, Cl- rushes in reducing EPSP
Depolarizing-causes slight depolarization at rest, and reduction of EPSP
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Term
| NMDA and AMPA Glutamate receptor |
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Definition
NMDA-Mg+ molecule in pore, need to depolarize cell a little bit to get K+ outflow to dislodge
AMPA- no Mg+ molecule
Co-incidence=AMPA small on its own, NMDA almost non-existant on its own
Memory Mechanism- addition of AMPA receptors |
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